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-
1
Sangkawibha N, Rojanasuphot S, Ahandrik S, Viriyapongse S, Jatanasen S, Salitul V, Phanthumachinda B, Halstead SB, 1984. Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreak. Am J Epidemiol 120 :653–669.
-
2
Guzman MG, Kouri G, Valdes L, Bravo J, Alvarez M, Vazquez S, Delgado I, Halstead SB, 2000. Epidemiological studies on dengue in Santiago de Cuba, 1997. Am J Epidemiol 152 :793–799.
-
3
Halstead SB, 1988. Pathogenesis of dengue. Challenges to molecular biology. Science 239 :476–481.
-
4
Kurane I, Takasaki T, 2001. Dengue fever and dengue haemorrhagic fever: challenges of controlling an enemy still at large. Rev Med Virol 11 :301–311.
-
5
Chatuverdi UC, Agarwal R, Elbishbishi EA, Mustafa AS, 2000. Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis. FEMS Immunol Med Microbiol 28 :183–188.
-
6
Mongkolsapaya J, Dejnirattisai W, Xu X, Vasanawathana S, Tangthawornchaikul N, Chairunsri A, Sawasdivorn S, Duangchinda T, Dong T, Rowlang-Jones S, Yenchitsomanus P, McMichel A, Malasit P, Screaton G, 2003. Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nat Med 9 :921–927.
-
7
Peterhans E, Grob M, Burge T, Zanoni R, 1987. Virus-induced formation of reactive oxygen intermediates in phagocytic cells. Free Radic Res Commun 3 :39–46.
-
8
Granger DN, Rutili G, McCord J, 1981. Superoxide radicals in feline intestinal ischemia. Gastroenterology 81 :22–29.
-
9
Irani K, 2000. Oxidant signaling in vascular cell growth, death, and survival. Circ Res 87 :179–183.
-
10
Yoshikawa T, 2002. Vascular dysfunction and free radicals. Free Radic Biol Med 33 :425–426.
-
11
Halliwell B, Gutteridge JMC, 1999.Free Radicals in Biology and Medicine. Third edition. Oxford, United Kingdom: Claredon Press.
-
12
Sahnoun Z, Jamoussi K, Zeghal KM, 1997. Free radicals and antioxidants: human physiology, pathology and therapeutics aspects. Therapie 52 :251–270.
-
13
Schwarz KB, 1996. Oxidative stress during viral infection - a review. Free Radic Biol Med 21 :64411–64419.
-
14
Peterhans E, 1997. Oxidants and antioxidants in viral disease: disease mechanism and metabolic regulations. J Nutr 127 (Suppl 5):962s–965s.
-
15
Zwart LL, Meerman JHN, Commandeur JNM, Vermeulen NPE, 1999. Biomarkers of free radical damage. Applications in experimental animals and in humans. Free Radical Biol Med 26 :202–226.
-
16
Toyokuni S, 1999. Reactive oxygen species-induced molecular damage and its application in pathology. Pathol Int 49 :91–102.
-
17
Akaike T, Noguchi Y, Ijiri S, Setoguchi K, Suga M, Zheng YM, Dietzschold B, Maeda H, 1996. Pathogenesis of influenza virus-induced pneumonia: involment of both nitric oxide and oxygen radicals. Proc Natl Acad Sci U S A 93 :2448–2453.
-
18
Gil L, Martínez G, González I, Tarinas A, Álvarez A, Molina R, Tápanes R, Pérez J, 2002. Evaluation of redox status and immunological indicators in HTLV-I seropositive subjects. Bio-quimia 27 :26–31.
-
19
Pelaez O, Guzmán MG, Kourí G, Pérez R, San Martin JL, Vázquez S, Rosario D, Mora R, Quintana I, Bisset J, Cancio R, Masa AM, Castro O, González D, Avila LC, Rodríguez R, Alvarez M, Pelegrino JL, Bernardo L, Prado I, 2004. Dengue 3 epidemic in Havana, 2001. Emerg Infect Dis 10 :719–722.
-
20
Pan American Health Organization, 1994. Dengue and Dengue Hemorrhagic Fever in the Americas: Guidelines for Prevention and Control. Scientific Publication No. 548. Washington, DC: Pan American Health Organization.
-
21
Vázquez S, Saenz E, Huelva G, González A, Kourí G, Guzmán MG, 1998. Detección de IgM contra el virus del dengue en sangre entera absorbida en papel de filtro. Rev Panam Salud Publica 3 :174–178.
-
22
Rodríguez R, Alvarez M, Guzmán MG, Morier L, Kourí G, 2000. Isolation of dengue 2 in C636/HT cells by rapid centrifugation/shell vial assay. Comparison with conventional virus isolation method. J Clin Microbiol 38 :3508–3510.
-
23
McLemore JL, Beeley P, Thorton K, Morriroe K, Blackwell W, Dasgupta A, 1998. Rapid automated determination of lipid hydroperoxide concentrations and total antioxidant status of serum samples from patients infected with HIV. Am J Clin Pathol 109 :268–273.
-
24
Radicales Libres, 1996. Crumlin, United Kingdom: Randox Laboratories, Ltd. 1–16.
-
25
Prior RL, Cao G, 1999. In vivo total antioxidant capacity: comparison of different analytical methods. Free Rad Biol Med 27 :1173–1181.
-
26
Ozdemirler G, Mehmetcik G, Oztezcan S, Toker G, Sivas A, Uysal M, 1995. Peroxidation potential and antioxidant activity of serum in patients with diabetes mellitus and myocard infarction. Horm Metab Res 271 :194–196.
-
27
Sedlak J, Lindsay RH, 1968. Estimation of total protein bound and non-protein sulfhydryl group in tissue with Ellman’s reagent. Anal Biochem 25 :192–205.
-
28
Erdelmeier I, Gerard D, Yadan JC, Chaudiere J, 1998. Reactions of N-methyl-2-phenyl-indole with malondialdehyde and 4-hydroxialkenals. Mechanistic aspects of the colorimetric assay of lipid peroxidation. Chem Res Toxicol 11 :1184–1194.
-
29
Cao G, Prior RL, 1998. Comparison of different analytical methods for assessing total antioxidant capacity of human plasma. Clin Chem 44 :1309–1315.
-
30
Gebicki JM, 1997. Protein hydroperoxides as new reactive oxygen species. Redox Rep 3 :99–110.
-
31
Hawkins CL, Davies MJ, 2001. Generation and propagation of radical reactions on proteins. Biochim Biophys Acta 1504 :196–216.
-
32
Kasapogu M, Ozben T, 2001. Alterations of antioxidant enzymes and oxidative stress markers in aging. Exp Gerontol 36 :209–222.
-
33
Yachie A, Toma T, Mizuno K, Okamoto H, Shimura S, Ohta K, Kasahara Y, Koizumi S, 2003. Heme oxygenase-1 production by peripheral blood monocytes during acute inflammatory illnesses of children. Exp Biol Med (Maywood) 228 :550–556.
-
34
Matsubara T, Ziff M, 1986. Increased superoxide anion release from human endothelial cells in response to cytokines. J Immunol 137 :3295–3298.
-
35
Anderson R, Wang S, Osiowy C, Issekutz AC, 1997. Activation of endothelial cells via antibody-enhanced dengue virus infection of peripheral blood monocytes. J Virol 71 :4226–4232.
-
36
Rothman AL, Ennis FA, 2000. Toga/flaviviruses: immunopathology. Cunningham MW, Fujinami RS, eds. Effects of Microbes on the Immune System. Philadelphia: Lippincott Williams and Wilkins, 473–490.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1294 | 1103 | 30 |
| Full Text Views | 404 | 10 | 1 |
| PDF Downloads | 163 | 9 | 1 |
OXIDATIVE STRESS IN ADULT DENGUE PATIENTS
LIZETTE GIL
LIZETTE GIL
Department of Clinical Pharmacology, and Department of Clinical Care, Hospital, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba; College of Pharmacy and Food, Havana University, Havana, Cuba; Virology department, Pan American Health Organization/World Health Organization Collaborating Center for Viral Diseases, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba
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GREGORIO MARTÍNEZ
GREGORIO MARTÍNEZ
Department of Clinical Pharmacology, and Department of Clinical Care, Hospital, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba; College of Pharmacy and Food, Havana University, Havana, Cuba; Virology department, Pan American Health Organization/World Health Organization Collaborating Center for Viral Diseases, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba
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ROLANDO TÁPANES
ROLANDO TÁPANES
Department of Clinical Pharmacology, and Department of Clinical Care, Hospital, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba; College of Pharmacy and Food, Havana University, Havana, Cuba; Virology department, Pan American Health Organization/World Health Organization Collaborating Center for Viral Diseases, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba
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OSVALDO CASTRO
OSVALDO CASTRO
Department of Clinical Pharmacology, and Department of Clinical Care, Hospital, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba; College of Pharmacy and Food, Havana University, Havana, Cuba; Virology department, Pan American Health Organization/World Health Organization Collaborating Center for Viral Diseases, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba
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DANIEL GONZÁLEZ
DANIEL GONZÁLEZ
Department of Clinical Pharmacology, and Department of Clinical Care, Hospital, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba; College of Pharmacy and Food, Havana University, Havana, Cuba; Virology department, Pan American Health Organization/World Health Organization Collaborating Center for Viral Diseases, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba
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LIDICE BERNARDO
LIDICE BERNARDO
Department of Clinical Pharmacology, and Department of Clinical Care, Hospital, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba; College of Pharmacy and Food, Havana University, Havana, Cuba; Virology department, Pan American Health Organization/World Health Organization Collaborating Center for Viral Diseases, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba
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SUSANA VÁZQUEZ
SUSANA VÁZQUEZ
Department of Clinical Pharmacology, and Department of Clinical Care, Hospital, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba; College of Pharmacy and Food, Havana University, Havana, Cuba; Virology department, Pan American Health Organization/World Health Organization Collaborating Center for Viral Diseases, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba
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GUSTAVO KOURÍ
GUSTAVO KOURÍ
Department of Clinical Pharmacology, and Department of Clinical Care, Hospital, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba; College of Pharmacy and Food, Havana University, Havana, Cuba; Virology department, Pan American Health Organization/World Health Organization Collaborating Center for Viral Diseases, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba
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MARÍA G. GUZMÁN
MARÍA G. GUZMÁN
Department of Clinical Pharmacology, and Department of Clinical Care, Hospital, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba; College of Pharmacy and Food, Havana University, Havana, Cuba; Virology department, Pan American Health Organization/World Health Organization Collaborating Center for Viral Diseases, Institute of Tropical Medicine Pedro Kourí, Havana, Cuba
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An association between viral diseases and increased oxidative stress has been suggested. The time course of serum levels of total antioxidant status (TAS), peroxidation potential (PP), glutathione (GSH), lipid peroxidation measured as hydroperoxides, and malondyaldehyde and 4-hydroxyalkenals (MDA + 4-HDA), as well as antioxidant enzymatic activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx), were measured in 22 serologically confirmed dengue patients. Most of the patients had dengue fever and three of them had dengue hemorrhagic fever. The redox parameters were compared with those of age- and sex- matched controls. No significant difference was observed for levels of GSH and TAS between patients and controls. Levels of PP, MDA + 4-HDA, and SOD were significantly higher. Levels of GPx and total hydroperoxides were significantly lower in patients in comparison with controls. These findings suggest that the alteration in redox status could result of increased oxidative stress and it may play a role in the pathogenesis of the disease.
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-
1
Sangkawibha N, Rojanasuphot S, Ahandrik S, Viriyapongse S, Jatanasen S, Salitul V, Phanthumachinda B, Halstead SB, 1984. Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreak. Am J Epidemiol 120 :653–669.
-
2
Guzman MG, Kouri G, Valdes L, Bravo J, Alvarez M, Vazquez S, Delgado I, Halstead SB, 2000. Epidemiological studies on dengue in Santiago de Cuba, 1997. Am J Epidemiol 152 :793–799.
-
3
Halstead SB, 1988. Pathogenesis of dengue. Challenges to molecular biology. Science 239 :476–481.
-
4
Kurane I, Takasaki T, 2001. Dengue fever and dengue haemorrhagic fever: challenges of controlling an enemy still at large. Rev Med Virol 11 :301–311.
-
5
Chatuverdi UC, Agarwal R, Elbishbishi EA, Mustafa AS, 2000. Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis. FEMS Immunol Med Microbiol 28 :183–188.
-
6
Mongkolsapaya J, Dejnirattisai W, Xu X, Vasanawathana S, Tangthawornchaikul N, Chairunsri A, Sawasdivorn S, Duangchinda T, Dong T, Rowlang-Jones S, Yenchitsomanus P, McMichel A, Malasit P, Screaton G, 2003. Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nat Med 9 :921–927.
-
7
Peterhans E, Grob M, Burge T, Zanoni R, 1987. Virus-induced formation of reactive oxygen intermediates in phagocytic cells. Free Radic Res Commun 3 :39–46.
-
8
Granger DN, Rutili G, McCord J, 1981. Superoxide radicals in feline intestinal ischemia. Gastroenterology 81 :22–29.
-
9
Irani K, 2000. Oxidant signaling in vascular cell growth, death, and survival. Circ Res 87 :179–183.
-
10
Yoshikawa T, 2002. Vascular dysfunction and free radicals. Free Radic Biol Med 33 :425–426.
-
11
Halliwell B, Gutteridge JMC, 1999.Free Radicals in Biology and Medicine. Third edition. Oxford, United Kingdom: Claredon Press.
-
12
Sahnoun Z, Jamoussi K, Zeghal KM, 1997. Free radicals and antioxidants: human physiology, pathology and therapeutics aspects. Therapie 52 :251–270.
-
13
Schwarz KB, 1996. Oxidative stress during viral infection - a review. Free Radic Biol Med 21 :64411–64419.
-
14
Peterhans E, 1997. Oxidants and antioxidants in viral disease: disease mechanism and metabolic regulations. J Nutr 127 (Suppl 5):962s–965s.
-
15
Zwart LL, Meerman JHN, Commandeur JNM, Vermeulen NPE, 1999. Biomarkers of free radical damage. Applications in experimental animals and in humans. Free Radical Biol Med 26 :202–226.
-
16
Toyokuni S, 1999. Reactive oxygen species-induced molecular damage and its application in pathology. Pathol Int 49 :91–102.
-
17
Akaike T, Noguchi Y, Ijiri S, Setoguchi K, Suga M, Zheng YM, Dietzschold B, Maeda H, 1996. Pathogenesis of influenza virus-induced pneumonia: involment of both nitric oxide and oxygen radicals. Proc Natl Acad Sci U S A 93 :2448–2453.
-
18
Gil L, Martínez G, González I, Tarinas A, Álvarez A, Molina R, Tápanes R, Pérez J, 2002. Evaluation of redox status and immunological indicators in HTLV-I seropositive subjects. Bio-quimia 27 :26–31.
-
19
Pelaez O, Guzmán MG, Kourí G, Pérez R, San Martin JL, Vázquez S, Rosario D, Mora R, Quintana I, Bisset J, Cancio R, Masa AM, Castro O, González D, Avila LC, Rodríguez R, Alvarez M, Pelegrino JL, Bernardo L, Prado I, 2004. Dengue 3 epidemic in Havana, 2001. Emerg Infect Dis 10 :719–722.
-
20
Pan American Health Organization, 1994. Dengue and Dengue Hemorrhagic Fever in the Americas: Guidelines for Prevention and Control. Scientific Publication No. 548. Washington, DC: Pan American Health Organization.
-
21
Vázquez S, Saenz E, Huelva G, González A, Kourí G, Guzmán MG, 1998. Detección de IgM contra el virus del dengue en sangre entera absorbida en papel de filtro. Rev Panam Salud Publica 3 :174–178.
-
22
Rodríguez R, Alvarez M, Guzmán MG, Morier L, Kourí G, 2000. Isolation of dengue 2 in C636/HT cells by rapid centrifugation/shell vial assay. Comparison with conventional virus isolation method. J Clin Microbiol 38 :3508–3510.
-
23
McLemore JL, Beeley P, Thorton K, Morriroe K, Blackwell W, Dasgupta A, 1998. Rapid automated determination of lipid hydroperoxide concentrations and total antioxidant status of serum samples from patients infected with HIV. Am J Clin Pathol 109 :268–273.
-
24
Radicales Libres, 1996. Crumlin, United Kingdom: Randox Laboratories, Ltd. 1–16.
-
25
Prior RL, Cao G, 1999. In vivo total antioxidant capacity: comparison of different analytical methods. Free Rad Biol Med 27 :1173–1181.
-
26
Ozdemirler G, Mehmetcik G, Oztezcan S, Toker G, Sivas A, Uysal M, 1995. Peroxidation potential and antioxidant activity of serum in patients with diabetes mellitus and myocard infarction. Horm Metab Res 271 :194–196.
-
27
Sedlak J, Lindsay RH, 1968. Estimation of total protein bound and non-protein sulfhydryl group in tissue with Ellman’s reagent. Anal Biochem 25 :192–205.
-
28
Erdelmeier I, Gerard D, Yadan JC, Chaudiere J, 1998. Reactions of N-methyl-2-phenyl-indole with malondialdehyde and 4-hydroxialkenals. Mechanistic aspects of the colorimetric assay of lipid peroxidation. Chem Res Toxicol 11 :1184–1194.
-
29
Cao G, Prior RL, 1998. Comparison of different analytical methods for assessing total antioxidant capacity of human plasma. Clin Chem 44 :1309–1315.
-
30
Gebicki JM, 1997. Protein hydroperoxides as new reactive oxygen species. Redox Rep 3 :99–110.
-
31
Hawkins CL, Davies MJ, 2001. Generation and propagation of radical reactions on proteins. Biochim Biophys Acta 1504 :196–216.
-
32
Kasapogu M, Ozben T, 2001. Alterations of antioxidant enzymes and oxidative stress markers in aging. Exp Gerontol 36 :209–222.
-
33
Yachie A, Toma T, Mizuno K, Okamoto H, Shimura S, Ohta K, Kasahara Y, Koizumi S, 2003. Heme oxygenase-1 production by peripheral blood monocytes during acute inflammatory illnesses of children. Exp Biol Med (Maywood) 228 :550–556.
-
34
Matsubara T, Ziff M, 1986. Increased superoxide anion release from human endothelial cells in response to cytokines. J Immunol 137 :3295–3298.
-
35
Anderson R, Wang S, Osiowy C, Issekutz AC, 1997. Activation of endothelial cells via antibody-enhanced dengue virus infection of peripheral blood monocytes. J Virol 71 :4226–4232.
-
36
Rothman AL, Ennis FA, 2000. Toga/flaviviruses: immunopathology. Cunningham MW, Fujinami RS, eds. Effects of Microbes on the Immune System. Philadelphia: Lippincott Williams and Wilkins, 473–490.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1294 | 1103 | 30 |
| Full Text Views | 404 | 10 | 1 |
| PDF Downloads | 163 | 9 | 1 |