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1
White NJ, Olliaro P, 1996. Strategies for the prevention of anti-malarial drug resistance: rationale for combination chemotherapy for malaria. Parasitol Today 12 :399–341.
-
2
White NJ, 1999. Delaying antimalarial drug resistance with combination chemotherapy. Parassitologia 41 :301–308.
-
3
Bloland PB, Ettling M, Meek S, 2000. Combination therapy for malaria in Africa: hype or hope? Bull World Health Organ 78 :1378–1388.
-
4
Depoortere E, Guthmann JP, Sipilnyambe N, Nkandu E, Fermon F, Balkan S, Legros D, 2004. Adherence to the combination of sulfadoxine-pyrimethamine and artesunate in the Maheba Refugee Settlement, Zambia. Trop Med Int Health 9 :1–6.
-
5
Depoortere E, Salvador ET, Stivanello E, Bisoffi Z, Guthmann JP. Adherence to a combination of artemether and lumefantrine (Coartem®) in Kajo Keji, Southern Sudan. Ann Trop Med Parasitol 98 :635–637.
-
6
Legros D, Johnson K, Houpikan P, Makanga M, Kabakyenga JK, Talisuna AO, Taylor WR, 2001. Clinical efficacy of chloroquine or sulfadoxine-pyrimethamine in children under five from south-western Uganda with uncomplicated falciparum malaria. Trans R Soc Trop Med Hyg 96 :199–201.
-
7
Priotto G, Kabakyenga J, Pinoges L, Ruiz A, Erikson T, Coussement F, Ngambe T, Taylor WRJ, Perea W, Guthmann JP, Olliaro P, Legros D, 2003. Artesunate and sulfadoxine-pyrimethamine combinations for the treatment of uncomplicated falciparum malaria in Uganda: a randomised, double-blind, placebo-controlled trial. Trans R Soc Trop Med Hyg 97 :325–330.
-
8
Kamya MR, Bakyaita NN, Talisuna AO, Were WM, Staedke SG, 2002. Increasing antimalarial drug resistance in Uganda and revision of the national drug policy. Trop Med Int Health 7 :1031–1041.
-
9
Lefèvre G, Looareesuwan S, Treeprasertsuk S, Krudsood S, Sila-chamroon U, Gathmann I, Mull R, Bakshi R, 2001. A clinical and pharmacokinetic trial of six doses of artemether-lumefantrine for multidrug-resistant Plasmodium falciparum malaria in Thailand. Am J Trop Med Hyg 64 :247–256.
-
10
van Vugt M, Ezzet F., Nosten F, Gathmann I, Wilairatana P, Looareesuwan S, White NJ, 1999. Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug resistant Plasmodium falciparum malaria. Am J Trop Med Hyg 60 :936–942.
-
11
van Vugt M, Looareesuwan S, Wilairatana P, McGready R, Villegas L, Gathmann I, Mull R, Brockman A, White NJ, Nosten F, 2000. Artemether-lumefantrine for the treatment of multi-drug-resistant falciparum malaria. Trans R Soc Trop Med Hyg 94 :545–548.
-
12
Mansor SM, Navaratnam V, Yahaya N, Nair NK, Wernsdorfer WH, Degen PH, 1996. Determination of a new antimalarial drug, benflumetol, in blood plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 682 :321– 325.
-
13
Qingjun L, Jihui D, Laiyi T, Xiangjun Z, Jun L, Hay A, Shires S, Navaratnam V, 1998. The effect of drug packaging on patients’ adherence with treatment for Plasmodium vivax malaria in China. Bull World Health Organ 76 :21–27.
-
14
Okonkwo PO, Akpala CO, Okafor HU, Mbah AU, Nwaiwu O, 2001. Compliance to correct dose of chloroquine in uncomplicated malaria correlates with improvement in the condition of rural Nigerian children. Trans R Soc Trop Med Hyg 95 :320–324.
-
15
Nosten F, Brasseur P, 2002. Combination therapy for malaria: the way forward? Drugs 62 :1315–1329.
-
16
Denis MB, 1998. Improving adherence with quinine + tetracycline for treatment of malaria: evaluation of health education interventions in Cambodian villages. Bull World Health Organ 76 :43–49.
-
17
Slutsker L, Chitsulo L, Macheso A, Steketee RW, 1994. Treatment of malaria fever episodes among children in Malawi: results of a KAP survey. Trop Med Parasitol 45 :61–64.
-
18
White NJ, van Vugt M, Ezzet F, 1999. Clinical pharmacokinetics and pharmacodynamics of artemether-lumefantrine. Clin Pharmacokinet 37 :105–125.
-
19
Ezzet F, van Vugt M, Nosten F, Looareesuwan S, White NJ, 2000. Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria. Antimicrobial Agents Chemother 44 :697–704.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 745 | 687 | 241 |
| Full Text Views | 370 | 11 | 2 |
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ADHERENCE TO A SIX-DOSE REGIMEN OF ARTEMETHER-LUMEFANTRINE FOR TREATMENT OF UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA IN UGANDA
CAROLE FOGG
CAROLE FOGG
Epicentre, Paris, France; Médecins Sans Frontières, Paris, France; Mbarara University of Science and Technology, Mbarara, Uganda; Mbarara University Teaching Hospital, Mbarara, Uganda
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FRANCIS BAJUNIRWE
FRANCIS BAJUNIRWE
Epicentre, Paris, France; Médecins Sans Frontières, Paris, France; Mbarara University of Science and Technology, Mbarara, Uganda; Mbarara University Teaching Hospital, Mbarara, Uganda
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PATRICE PIOLA
PATRICE PIOLA
Epicentre, Paris, France; Médecins Sans Frontières, Paris, France; Mbarara University of Science and Technology, Mbarara, Uganda; Mbarara University Teaching Hospital, Mbarara, Uganda
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SAMUEL BIRARO
SAMUEL BIRARO
Epicentre, Paris, France; Médecins Sans Frontières, Paris, France; Mbarara University of Science and Technology, Mbarara, Uganda; Mbarara University Teaching Hospital, Mbarara, Uganda
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FRANCESCO CHECCHI
FRANCESCO CHECCHI
Epicentre, Paris, France; Médecins Sans Frontières, Paris, France; Mbarara University of Science and Technology, Mbarara, Uganda; Mbarara University Teaching Hospital, Mbarara, Uganda
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JAMES KIGULI
JAMES KIGULI
Epicentre, Paris, France; Médecins Sans Frontières, Paris, France; Mbarara University of Science and Technology, Mbarara, Uganda; Mbarara University Teaching Hospital, Mbarara, Uganda
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PROSCOVIA NAMIIRO
PROSCOVIA NAMIIRO
Epicentre, Paris, France; Médecins Sans Frontières, Paris, France; Mbarara University of Science and Technology, Mbarara, Uganda; Mbarara University Teaching Hospital, Mbarara, Uganda
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JOY MUSABE
JOY MUSABE
Epicentre, Paris, France; Médecins Sans Frontières, Paris, France; Mbarara University of Science and Technology, Mbarara, Uganda; Mbarara University Teaching Hospital, Mbarara, Uganda
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AGNES KYOMUGISHA
AGNES KYOMUGISHA
Epicentre, Paris, France; Médecins Sans Frontières, Paris, France; Mbarara University of Science and Technology, Mbarara, Uganda; Mbarara University Teaching Hospital, Mbarara, Uganda
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JEAN-PAUL GUTHMANN
JEAN-PAUL GUTHMANN
Epicentre, Paris, France; Médecins Sans Frontières, Paris, France; Mbarara University of Science and Technology, Mbarara, Uganda; Mbarara University Teaching Hospital, Mbarara, Uganda
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Measuring baseline levels of adherence and identifying risk factors for non-adherence are important steps before the introduction of new antimalarials. In Mbarara in southwestern Uganda, we assessed adherence to artemether-lumefantrine (Coartem®) in its latest World Health Organization blister formulation. Patients with uncomplicated Plasmodium falciparum malaria were prescribed artemether-lumefantrine and received an explanation of how to take the following five doses at home. A tablet count was made and a questionnaire was completed during a home visit. Among 210 analyzable patients, 21 (10.0%) were definitely or probably non-adherent, whereas 189 (90.0%) were probably adherent. Age group was not associated with adherence. Lack of formal education was the only factor associated with non-adherence after controlling for confounders (odds ratio = 3.1, 95% confidence interval [CI] = 1.1–9.7). Mean lumefantrine blood levels were lower among non-adherent (n = 16) (2.76 μg/mL, 95% CI = 1.06–4.45) than among adherent (n = 171) (3.19 μg/mL, 95% CI = 2.84–3.54) patients, but this difference was not statistically significant. The high adherence to artemether-lumefantrine found in our study suggest that this drug is likely to be very effective in Mbarara provided that patients receive clear dosage explanations.
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-
1
White NJ, Olliaro P, 1996. Strategies for the prevention of anti-malarial drug resistance: rationale for combination chemotherapy for malaria. Parasitol Today 12 :399–341.
-
2
White NJ, 1999. Delaying antimalarial drug resistance with combination chemotherapy. Parassitologia 41 :301–308.
-
3
Bloland PB, Ettling M, Meek S, 2000. Combination therapy for malaria in Africa: hype or hope? Bull World Health Organ 78 :1378–1388.
-
4
Depoortere E, Guthmann JP, Sipilnyambe N, Nkandu E, Fermon F, Balkan S, Legros D, 2004. Adherence to the combination of sulfadoxine-pyrimethamine and artesunate in the Maheba Refugee Settlement, Zambia. Trop Med Int Health 9 :1–6.
-
5
Depoortere E, Salvador ET, Stivanello E, Bisoffi Z, Guthmann JP. Adherence to a combination of artemether and lumefantrine (Coartem®) in Kajo Keji, Southern Sudan. Ann Trop Med Parasitol 98 :635–637.
-
6
Legros D, Johnson K, Houpikan P, Makanga M, Kabakyenga JK, Talisuna AO, Taylor WR, 2001. Clinical efficacy of chloroquine or sulfadoxine-pyrimethamine in children under five from south-western Uganda with uncomplicated falciparum malaria. Trans R Soc Trop Med Hyg 96 :199–201.
-
7
Priotto G, Kabakyenga J, Pinoges L, Ruiz A, Erikson T, Coussement F, Ngambe T, Taylor WRJ, Perea W, Guthmann JP, Olliaro P, Legros D, 2003. Artesunate and sulfadoxine-pyrimethamine combinations for the treatment of uncomplicated falciparum malaria in Uganda: a randomised, double-blind, placebo-controlled trial. Trans R Soc Trop Med Hyg 97 :325–330.
-
8
Kamya MR, Bakyaita NN, Talisuna AO, Were WM, Staedke SG, 2002. Increasing antimalarial drug resistance in Uganda and revision of the national drug policy. Trop Med Int Health 7 :1031–1041.
-
9
Lefèvre G, Looareesuwan S, Treeprasertsuk S, Krudsood S, Sila-chamroon U, Gathmann I, Mull R, Bakshi R, 2001. A clinical and pharmacokinetic trial of six doses of artemether-lumefantrine for multidrug-resistant Plasmodium falciparum malaria in Thailand. Am J Trop Med Hyg 64 :247–256.
-
10
van Vugt M, Ezzet F., Nosten F, Gathmann I, Wilairatana P, Looareesuwan S, White NJ, 1999. Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug resistant Plasmodium falciparum malaria. Am J Trop Med Hyg 60 :936–942.
-
11
van Vugt M, Looareesuwan S, Wilairatana P, McGready R, Villegas L, Gathmann I, Mull R, Brockman A, White NJ, Nosten F, 2000. Artemether-lumefantrine for the treatment of multi-drug-resistant falciparum malaria. Trans R Soc Trop Med Hyg 94 :545–548.
-
12
Mansor SM, Navaratnam V, Yahaya N, Nair NK, Wernsdorfer WH, Degen PH, 1996. Determination of a new antimalarial drug, benflumetol, in blood plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 682 :321– 325.
-
13
Qingjun L, Jihui D, Laiyi T, Xiangjun Z, Jun L, Hay A, Shires S, Navaratnam V, 1998. The effect of drug packaging on patients’ adherence with treatment for Plasmodium vivax malaria in China. Bull World Health Organ 76 :21–27.
-
14
Okonkwo PO, Akpala CO, Okafor HU, Mbah AU, Nwaiwu O, 2001. Compliance to correct dose of chloroquine in uncomplicated malaria correlates with improvement in the condition of rural Nigerian children. Trans R Soc Trop Med Hyg 95 :320–324.
-
15
Nosten F, Brasseur P, 2002. Combination therapy for malaria: the way forward? Drugs 62 :1315–1329.
-
16
Denis MB, 1998. Improving adherence with quinine + tetracycline for treatment of malaria: evaluation of health education interventions in Cambodian villages. Bull World Health Organ 76 :43–49.
-
17
Slutsker L, Chitsulo L, Macheso A, Steketee RW, 1994. Treatment of malaria fever episodes among children in Malawi: results of a KAP survey. Trop Med Parasitol 45 :61–64.
-
18
White NJ, van Vugt M, Ezzet F, 1999. Clinical pharmacokinetics and pharmacodynamics of artemether-lumefantrine. Clin Pharmacokinet 37 :105–125.
-
19
Ezzet F, van Vugt M, Nosten F, Looareesuwan S, White NJ, 2000. Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria. Antimicrobial Agents Chemother 44 :697–704.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 745 | 687 | 241 |
| Full Text Views | 370 | 11 | 2 |
| PDF Downloads | 95 | 7 | 0 |