INTRODUCTION OF THE AMERICAN/ASIAN GENOTYPE OF DENGUE 2 VIRUS INTO THE YUCATAN STATE OF MEXICO

MARÍA A. LOROÑO-PINO Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Merida, Yucatan, Mexico; Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Departamento de Medicina Preventiva, Hospital General Regional No. 12, Benito Juárez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico; Dirección de Prevención y Control de Enfermedades, Secretaría de Salud de Yucatán, Merida, Yucatan, Mexico

Search for other papers by MARÍA A. LOROÑO-PINO in
Current site
Google Scholar
PubMed
Close
,
JOSÉ A. FARFÁN-ALE Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Merida, Yucatan, Mexico; Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Departamento de Medicina Preventiva, Hospital General Regional No. 12, Benito Juárez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico; Dirección de Prevención y Control de Enfermedades, Secretaría de Salud de Yucatán, Merida, Yucatan, Mexico

Search for other papers by JOSÉ A. FARFÁN-ALE in
Current site
Google Scholar
PubMed
Close
,
ALICIA L. ZAPATA-PERAZA Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Merida, Yucatan, Mexico; Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Departamento de Medicina Preventiva, Hospital General Regional No. 12, Benito Juárez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico; Dirección de Prevención y Control de Enfermedades, Secretaría de Salud de Yucatán, Merida, Yucatan, Mexico

Search for other papers by ALICIA L. ZAPATA-PERAZA in
Current site
Google Scholar
PubMed
Close
,
ELSY P. ROSADO-PAREDES Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Merida, Yucatan, Mexico; Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Departamento de Medicina Preventiva, Hospital General Regional No. 12, Benito Juárez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico; Dirección de Prevención y Control de Enfermedades, Secretaría de Salud de Yucatán, Merida, Yucatan, Mexico

Search for other papers by ELSY P. ROSADO-PAREDES in
Current site
Google Scholar
PubMed
Close
,
LUIS F. FLORES-FLORES Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Merida, Yucatan, Mexico; Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Departamento de Medicina Preventiva, Hospital General Regional No. 12, Benito Juárez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico; Dirección de Prevención y Control de Enfermedades, Secretaría de Salud de Yucatán, Merida, Yucatan, Mexico

Search for other papers by LUIS F. FLORES-FLORES in
Current site
Google Scholar
PubMed
Close
,
JULIÁN E. GARCÍA-REJÓN Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Merida, Yucatan, Mexico; Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Departamento de Medicina Preventiva, Hospital General Regional No. 12, Benito Juárez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico; Dirección de Prevención y Control de Enfermedades, Secretaría de Salud de Yucatán, Merida, Yucatan, Mexico

Search for other papers by JULIÁN E. GARCÍA-REJÓN in
Current site
Google Scholar
PubMed
Close
,
FRANCISCO J. DÍAZ Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Merida, Yucatan, Mexico; Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Departamento de Medicina Preventiva, Hospital General Regional No. 12, Benito Juárez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico; Dirección de Prevención y Control de Enfermedades, Secretaría de Salud de Yucatán, Merida, Yucatan, Mexico

Search for other papers by FRANCISCO J. DÍAZ in
Current site
Google Scholar
PubMed
Close
,
BRADLEY J. BLITVICH Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Merida, Yucatan, Mexico; Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Departamento de Medicina Preventiva, Hospital General Regional No. 12, Benito Juárez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico; Dirección de Prevención y Control de Enfermedades, Secretaría de Salud de Yucatán, Merida, Yucatan, Mexico

Search for other papers by BRADLEY J. BLITVICH in
Current site
Google Scholar
PubMed
Close
,
MANUEL ANDRADE-NARVÁEZ Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Merida, Yucatan, Mexico; Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Departamento de Medicina Preventiva, Hospital General Regional No. 12, Benito Juárez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico; Dirección de Prevención y Control de Enfermedades, Secretaría de Salud de Yucatán, Merida, Yucatan, Mexico

Search for other papers by MANUEL ANDRADE-NARVÁEZ in
Current site
Google Scholar
PubMed
Close
,
EUSEBIO JIMÉNEZ-RÍOS Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Merida, Yucatan, Mexico; Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Departamento de Medicina Preventiva, Hospital General Regional No. 12, Benito Juárez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico; Dirección de Prevención y Control de Enfermedades, Secretaría de Salud de Yucatán, Merida, Yucatan, Mexico

Search for other papers by EUSEBIO JIMÉNEZ-RÍOS in
Current site
Google Scholar
PubMed
Close
,
CAROL D. BLAIR Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Merida, Yucatan, Mexico; Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Departamento de Medicina Preventiva, Hospital General Regional No. 12, Benito Juárez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico; Dirección de Prevención y Control de Enfermedades, Secretaría de Salud de Yucatán, Merida, Yucatan, Mexico

Search for other papers by CAROL D. BLAIR in
Current site
Google Scholar
PubMed
Close
,
KEN E. OLSON Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Merida, Yucatan, Mexico; Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Departamento de Medicina Preventiva, Hospital General Regional No. 12, Benito Juárez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico; Dirección de Prevención y Control de Enfermedades, Secretaría de Salud de Yucatán, Merida, Yucatan, Mexico

Search for other papers by KEN E. OLSON in
Current site
Google Scholar
PubMed
Close
,
WILLIAM BLACK IV Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Merida, Yucatan, Mexico; Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Departamento de Medicina Preventiva, Hospital General Regional No. 12, Benito Juárez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico; Dirección de Prevención y Control de Enfermedades, Secretaría de Salud de Yucatán, Merida, Yucatan, Mexico

Search for other papers by WILLIAM BLACK IV in
Current site
Google Scholar
PubMed
Close
, and
BARRY J. BEATY Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatan, Merida, Yucatan, Mexico; Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Departamento de Medicina Preventiva, Hospital General Regional No. 12, Benito Juárez, Instituto Mexicano del Seguro Social, Merida, Yucatan, Mexico; Dirección de Prevención y Control de Enfermedades, Secretaría de Salud de Yucatán, Merida, Yucatan, Mexico

Search for other papers by BARRY J. BEATY in
Current site
Google Scholar
PubMed
Close
Restricted access

A dengue (DEN) outbreak occurred in the Yucatan State of Mexico in 2002. Three isolates were obtained from patients presenting with DEN-like symptoms, and examined by partial nucleotide sequencing and phylogenetic analysis. The isolates were identified as DEN-2 viruses of the American-Asian genotype; this is the first report of this genotype in the Yucatan State. The DEN-2 viruses of the American-Asian genotype have been associated with more severe disease outcomes. Thus, its introduction into the Yucatan State presents a serious problem to public health authorities. During this outbreak, DEN virus infection was confirmed in 18% (282 of 1,560) of the patients who presented with DEN-like symptoms. Of these, 87 (31%) patients met the World Health Organization criteria for dengue hemorrhagic fever, including two patients who died. The majority (77%) of the patients experienced secondary infections in this epidemic.

Author Notes

  • 1

    Burke DS, Monath TP, 2001. Flaviviruses. Knipe DM, Howley PM, eds. Fields Virology. Fourth edition. Philadelphia, PA: Lippincott Williams and Wilkins, 1043–1126.

    • PubMed
    • Export Citation
  • 2

    Gubler DJ, 1988. Dengue. Monath TP, ed. The Arboviruses: Epidemiology and Ecology. Volume II. Boca Raton, FL: CRC Press, 223–260.

    • PubMed
    • Export Citation
  • 3

    Pan American Health Organization, 1981. Dengue in Mexico and in the United States. Epidemiol Bull 2 :9–11.

  • 4

    Loroño Pino MA, Farfán Ale JA, Rosado Paredes EP, Kuno G, Gubler DJ, 1993. Epidemic dengue 4 in the Yucatán, México, 1984. Rev Inst Med Trop Sao Paulo 35 :449–455.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5

    Centers for Disease Control and Prevention, 1982. Dengue type 1 in Mexico. MMWR Morb Mortal Wkly Rep 31 :468, 473–474.

  • 6

    Twiddy SS, Farrar JJ, Vinh Chau N, Wills B, Gould E, Gritsun T, Lloyd G, Holmes EC, 2002. Phylogenetic relationships and differential selection pressures among genotypes of dengue-2 virus. Virology 298 :63–72.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7

    Kouri GP, Guzman MG, Bravo JR, Triana C, 1989. Dengue haemorrhagic fever/dengue shock syndrome: lessons from the Cuban epidemic, 1981. Bull World Health Organ 67 :375–380.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8

    Rico-Hesse R, 1990. Molecular distribution of dengue viruses type 1 and 2 in nature. Virology 174 :479–493.

  • 9

    Rico-Hesse R, Harrison LM, Salas RA, Tovar D, Nisalak A, Ramos C, Boshell J, de Mesa MT, Nogueira RN, da Rosa AT, 1997. Origins of dengue type 2 viruses associated with increased pathogenesis in the Americas. Virology 230 :244–251.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10

    Centers for Disease Control and Prevention, 1994. Dengue type 3 infection, Nicaragua and Panama, October-November 1994. JAMA 273 :840–841.

  • 11

    Guzman MG, Vazquez S, Martinez E, Alvarez M, Rodriguez R, Kouri G, de los Reyes J, Acevedo F, 1996. Dengue in Nicaragua: reintroduction of serotype 3 in the Americas. Bol Oficina Sanit Panam 121 :102–110.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12

    Usuku S, Castillo L, Sugimoto C, Noguchi Y, Yogo Y, Kobayashi N, 2001. Phylogenetic analysis of dengue-3 viruses prevalent in Guatemala during 1996–1998. Arch Virol 146 :1381–1390.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13

    Wittke V, Robb TE, Thu HM, Nisalak A, Nimmannitya S, Kalayanrooj S, Vaughn DW, Endy TP, Holmes EC, Aaskov JG, 2002. Extinction and rapid emergence of strains of dengue 3 virus during an interepidemic period. Virology 301 :148–156.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14

    Thu HM, Lowry K, Myint TT, Shwe TN, Han AM, Khin KK, Thant KZ, Thein S, Aaskov J, 2004. Myanmar dengue outbreak associated with displacement of serotypes 2, 3, and 4 by dengue 1. Emerg Infect Dis 10 :593–597.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15

    WHO, 1997. Dengue Hemorrhagic Fever: Diagnosis, Treatment and Control. Second edition. Geneva: World Health Organization.

    • PubMed
    • Export Citation
  • 16

    Dean AG, Dean JA, Coulombier D, Brendel KA, Smith DC, Burton AH, Dicker RC, Sullivan K, Fagan RF, Arner TG, 1996. Epi Info, Version 6: A Word Processing, Database, and Statistics Program for Public Health on IBM-Compatible Microcomputers. Atlanta, GA: Centers for Disease Control and Prevention.

    • PubMed
    • Export Citation
  • 17

    Kuno G, Gomez I, Gubler DJ, 1991. An ELISA procedure for the diagnosis of dengue infections. J Virol Methods 33 :101–113.

  • 18

    Roehrig JT, Mathews JH, Trent DW, 1983. Identification of epitopes on the E glycoprotein of Saint Louis encephalitis virus using monoclonal antibodies. Virology 128 :118–126.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19

    Clarke DH, Casals J, 1958. Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses. Am J Trop Med Hyg 7 :561–577.

  • 20

    Henchal EA, McCown JM, Seguin MC, Gentry MK, Brandt WE, 1983. Rapid identification of dengue virus isolates by using monoclonal antibodies in an indirect immunofluorescence assay. Am J Trop Med Hyg 32 :164–169.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21

    Gubler DJ, Kuno G, Sather GE, Velez M, Oliver A, 1984. Mosquito cell cultures and specific monoclonal antibodies in surveillance for dengue viruses. Am J Trop Med Hyg 33 :158–165.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22

    Lanciotti RS, Calisher CH, Gubler DJ, Chang G-J, Vorndam V, 1992. Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol 30 :545–551.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23

    Swofford DL, 1998. PAUP*. Phylogenetic Analysis Using Parsimony (*and Other Methods). Version 4. Sunderland, MA: Sinauer Associates.

    • PubMed
    • Export Citation
  • 24

    Díaz FJ, Farfán-Ale JA, Olson KE, Loroño-Pino MA, Gubler DJ, Blair CD, Black WC IV, Beaty BJ, 2002. Genetic variation within the premembrane coding region of dengue viruses from the Yucatan Península of Mexico. Am J Trop Med Hyg 67 :93–101.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25

    Tolou H, Coussinier-Paris P, Mercier V, Pisano MR, de Lamballeie X, de Micco P, Durand J-P, 2000. Complete genomic sequence of a dengue type 2 virus from the French West Indies. Biochem Biophys Res Commun 277 :89–92.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26

    Armstrong PM, Rico-Hesse R, 2003. Efficiency of dengue serotype 2 virus strains to infect and disseminate in Aedes aegypti. Am J Trop Med Hyg 68 :539–544.

  • 27

    Guzman MG, Deubel V, Pelegrino JL, Rosario D, Marrero M, Sariol C, Kouri G, 1995. Partial nucleotide and amino acid sequences of the envelope and the envelope/nonstructural protein-1 gene junction of four dengue-2 virus strains isolated during the 1981 Cuban epidemic. Am J Trop Med Hyg 52 :241–246.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28

    Sariol CA, Pelegrino JL, Martinez A, Arteaga E, Kouri G, Guzman MG, 1999. Detection and genetic relationship of dengue virus sequences in seventeen-year-old paraffin-embedded samples from Cuba. Am J Trop Med Hyg 61 :994–1000.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 29

    Pan American Health Organization, 1990. Dengue hemorrhagic fever in Venezuela. Epidemiol Bull 11 :7–9.

  • 30

    Pan American Health Organization, 1992. Dengue and dengue haemorrhagic fever in the Americas: an overview of the problem. Epidemiol Bull 13 :9–10.

  • 31

    Nogueira RM, Miagostovich MP, Lampe E, Souza RW, Zagne SM, Schatzmayr HG, 1993. Dengue epidemic in the stage of Rio de Janeiro, Brazil, 1990–1: co-circulation of dengue 1 and dengue 2 serotypes. Epidemiol Infect 111 :163–170.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 32

    Aviles G, Rangeon G, Baroni P, Paz V, Monteros M, Sartini JL, Enria D, 2000. Outbreak of dengue-2 virus in Salta, Argentina, 1988. Medicina (B Aires) 60 :875–879.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 33

    Briseno-Garcia B, Gomez-Dantes H, Argott-Ramirez E, Montesano R, Vazquez-Martinez AL, Ibanez-Bernal S, Madrigal-Ayala G, Ruiz-Matus C, Flisser A, Tapia-Conyer R, 1996. Potential risk for dengue hemorrhagic fever: the isolation of serotype dengue-3 in Mexico. Emerg Infect Dis 2 :133–135.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 34

    Guzman MG, Kouri G, Valdes L, Bravo J, Alvarez M, Vazques S, Delgado I, Halstead SB, 2000. Epidemiologic studies on Dengue in Santiago de Cuba, 1997. Am J Epidemiol 152 :793–799.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 35

    Balmaseda A, Guzmán MG, Hammond S, Robleto G, Flores C, Tellez Y, Videa E, Saborio S, Pérez L, Sandoval E, Rodríguez Y, Harris E, 2003. Diagnosis of dengue virus infection by detection of specific immunoglobulin M (IgM) and IgA antibodies in serum and saliva. Clin Diagn Lab Immunol 10 :317–322.

    • PubMed
    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 89 89 9
Full Text Views 283 7 0
PDF Downloads 85 3 0
 
Membership Banner
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save