PHYSIOGRAPHIC AND ENTOMOLOGIC RISK FACTORS OF MALARIA IN ASSAM, INDIA

VAS DEV Malaria Research Centre (Indian Council of Medical Research), Sonapur, Assam, India; Malaria Research Centre (Indian Council of Medical Research), Delhi, India; DevOps (Pfizer)–India, Jogeshwari (W), Mumbai, India

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SOBHAN PHOOKAN Malaria Research Centre (Indian Council of Medical Research), Sonapur, Assam, India; Malaria Research Centre (Indian Council of Medical Research), Delhi, India; DevOps (Pfizer)–India, Jogeshwari (W), Mumbai, India

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VINOD P. SHARMA Malaria Research Centre (Indian Council of Medical Research), Sonapur, Assam, India; Malaria Research Centre (Indian Council of Medical Research), Delhi, India; DevOps (Pfizer)–India, Jogeshwari (W), Mumbai, India

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SURAJ P. ANAND Malaria Research Centre (Indian Council of Medical Research), Sonapur, Assam, India; Malaria Research Centre (Indian Council of Medical Research), Delhi, India; DevOps (Pfizer)–India, Jogeshwari (W), Mumbai, India

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Fever surveys were conducted in several districts of the Indian state of Assam to ascertain the prevalence of malaria in relation to vector abundance, entomologic inoculation rates (EIRs), and geographic location of human settlements. Anopheles minimus were incriminated, but their relative abundance and biting rates varied among districts, and no significant correlation was observed between these two indicators (r = 0.43, P = 0.34). Plasmodium falciparum was the predominant parasite species except in two districts where P. vivax was the majority parasite. The EIRs per person/night were 0.46–0.71 in P. falciparum-predominant areas and 0.12 in the district where P. vivax predominated. The correlation of percentage of fever cases positive for malaria infection in each district with the corresponding EIR was not significant (r = 0.6, P = 0.21). Malaria cases were detected in all months of the year but peaked during May–June, which corresponded to the months of heavy rainfall. These were also the months with highest incidence of infection with P. falciparum. Malaria cases were observed in all age groups of both sexes, and there was clustering of cases in villages near the vector-breeding habitat (perennial seepage streams), and foothill villages. However, malaria incidences were consistently lower in villages within 5 km of the nearest health care facility, which were in town areas. The data presented are indicative of low-to-moderate levels of malaria transmission by An. minimus, and would be of value for developing future intervention strategies.

Author Notes

Reprint requests: Vas Dev, Malaria Research Centre, PO Sonapur, Kamrup, Assam 782 402, India.
  • 1

    Dev V, 1996. Anopheles minimus: Its bionomics and role in the transmission of malaria in Assam, India. Bull World Health Organ 74 :61–66.

  • 2

    Dev V, Hira CR, Rajkhowa MK, 2001. Malaria-attributable morbidly in Assam, north-eastern India. Ann Trop Med Parasitol 95 :789–796.

  • 3

    Dev V, Phookan S, Barman K, 2003. Therapeutic efficacies of antimalarial drugs in the treatment of uncomplicated Plasmodium falciparum malaria in Assam, north-eastern India. Ann Trop Med Parasitol 97 :783–791.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4

    Dua VK, Dev V, Phookan S, Gupta NC, Sharma VP, Subbarao SK, 2003. Multi-drug resistant P. falciparum malaria in Assam, India: timing of recurrence and anti-malarial drug concentrations in whole blood. Am J Trop Med Hyg 69 :555–557.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5

    Sharma VP, 2000. Status of drug resistance in malaria in India. Mahajan RC, ed. Multi-Drug Resistance in Emerging and Re-Emerging Diseases. Delhi: Narosa Publications, 191–202.

    • PubMed
    • Export Citation
  • 6

    Dev V, Ansari MA, Hira CR, Barman K, 2001. An outbreak of Plasmodium falciparum malaria due to Anopheles minimus in central Assam. Indian J Malariol 38 :32–38.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7

    Singh J, Bhattacharya LM, 1944. Rapid staining of malarial parasites by a water-soluble stain. Indian Med Gaz 79 :102–104.

  • 8

    Green CA, Gass RF, Munstermann LE, Biamai V, 1990. Population genetic evidence for two species in Anopheles minimus in Thailand. Med Vet Entomol 4 :25–34.

  • 9

    Carter R, Mendis KN, Roberts D, 2000. Spatial targeting of interventions against malaria. Bull World Health Organ 78 :1401–1411.

  • 10

    Beier JC, Oster CN, Onyango FK, Bales JD, Sherwood JA, Perkins PV, Chumo DK, Koech DV, Whitmire RE, Roberts CR, Diggs CL, Hoffman SL, 1994. Plasmodium falciparum incidence relative to entomological inoculation rates at a site proposed for testing malaria vaccines in western Kenya. Am J Trop Med Hyg 50 :529–536.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11

    Alles HK, Mendis KN, Carter R, 1998. Malaria mortality rates in south Asia and in Africa: implications for malaria control. Parasitol Today 14 :369–375.

  • 12

    Mbogo CNM, Snow RW, Khamala CPM, Kabiru EW, Ouma JH, Githure JI, Marsh K, Beier JC, 1995. Relationships between Plasmodium falciparum transmission by vector populations and the incidence of severe disease at nine sites on the Kenyan coast. Ann Trop Med Parasitol 52 :201–206.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13

    Trape JF, Rogier C, 1996. Combating malaria morbidity and mortality by reducing transmission. Parasitol Today 12 :236–240.

  • 14

    Fox E, Strickland GT, 1989. The interrelationship of Plasmodium falciparum and P. vivax in Panjab. Trans R Soc Trop Med Hyg 83 :471–473.

  • 15

    Noden BH, Kent MD, Beier JC, 1995. The impact of variations in temperature on early Plasmodium falciparum development in Anopheles stephensi.Parasitology 111 :539–545.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16

    Marsh K, 1992. Malaria - a neglected disease. Parasitology 104 :S53–S69.

  • 17

    Carter R, Mendis KN, 2002. Evolutionary and historical aspects of the burden of malaria. Clin Microbiol Rev 15 :564–594.

  • 18

    Dev V, 1994. Breeding habitats of anopheline mosquitoes in Assam. Indian J Malariol 31 :31–34.

  • 19

    Mendis C, Gamage-Mendis AC, de Zoysa AP, Abhayawardena TA, Carter R, Herath PR, Mendis KN, 1990. Characteristics of malaria transmission in Kataragama, Sri Lanka: a focus for immuno-epidemiological studies. Am J Trop Med Hyg 42 :298–308.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20

    Gamage-Mendis AC, Carter R, Mendis C, de Zoysa APK, Hearth PRJ, Mendis KN, 1991. Clustering of malaria infections within an endemic population: risk of malaria associated with the type of housing construction. Am J Trop Med Hyg 45 :77–85.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21

    van der Hoek W, Kondrasen F, Dijkstra DS, Amerasinghe PH, Amerasinghe FP, 1998. Risk factors for malaria: a micro-epidemiological study in a village in Sri Lanka. Trans R Soc Trop Med Hyg 92 :265–269.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22

    Mohapatra PK, Narain K, Prakash A, Bhattacharyya DR, Mahanta J, 2001. Risk factors of malaria in the fringes of an evergreen monsoon forest of Arunachal Pradesh. Natl Med J India 14 :139–142.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23

    Sharma VP, 2003. Malaria and poverty in India. Curr Sci 84 :513–515.

  • 24

    Sachs J, Malaney P, 2002. The economic and social burden of malaria. Nature 415 :680–685.

  • 25

    Greenwood B, Mutabingwa T, 2002. Malaria in 2002. Nature 415 :670–672.

  • 26

    Jana-Kara BR, Jihullah WA, Shahi B, Dev V, Curtis CF, Sharma VP, 1995. Deltamethrin impregnated bednets against Anopheles minimus transmitted malaria in Assam, India. J Trop Med Hyg 98 :73–83.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27

    Dev V, 1998. Insecticide impregnated mosquito nets: an alternative strategy for malaria control. Curr Sci 74 :5.

  • 28

    Woolhouse MEJ, Dye C, Etard JF, Smith T, Charlood JD, Garnett GP, Hagen P, Hii JKL, Ndhlovu PD, Quinnell RJ, Watts CH, Chandiwana SK, Anderson RM, 1997. Heterogeneities in the transmission of infectious agents: implications for the design of control programs. Proc Natl Acad Sci USA 94 :338–342.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 29

    Scott TW, Takken W, Knols BGJ, Boete C, 2002. The ecology of genetically modified mosquitoes. Science 298 :117–119.

  • 30

    Carter R, 2002. Spatial simulation of malaria transmission and its control by malaria transmission blocking vaccination. Int J Parasitol 32 :1617–1624.

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