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PREVALENCE AND PREDICTORS OF HELICOBACTER PYLORI INFECTION IN CHILDREN AND ADULTS FROM THE PENAN ETHNIC MINORITY OF MALAYSIAN BORNEO

SIMON SIONG SING HUANGFaculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kuching, Malaysia; University of Western Australia, School of Medicine and Pharmacology, Fremantle Hospital, Fremantle, Australia

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ABDUL KARIM RUSS HASSANFaculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kuching, Malaysia; University of Western Australia, School of Medicine and Pharmacology, Fremantle Hospital, Fremantle, Australia

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KENG EE CHOOFaculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kuching, Malaysia; University of Western Australia, School of Medicine and Pharmacology, Fremantle Hospital, Fremantle, Australia

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MOHAMAD ISWANDY IBRAHIMFaculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kuching, Malaysia; University of Western Australia, School of Medicine and Pharmacology, Fremantle Hospital, Fremantle, Australia

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TIMOTHY M. E. DAVISFaculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kuching, Malaysia; University of Western Australia, School of Medicine and Pharmacology, Fremantle Hospital, Fremantle, Australia

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To determine the prevalence of Helicobacter pylori antigen carriage in stool in the Penan ethnic minority in Malaysian Borneo, we studied 295 Penans 0.6–89.0 years of age from 1) the remote Limbang Division, 2) Mulu regional center, and 3) Belaga village. Overall, 37.7% of the subjects tested positive. Peak prevalence was reached by 10 years of age. There were no differences in age, sex, body mass index, and socioeconomic/domestic variables between antigen-positive and antigen-negative subjects. In a logistic regression analysis, subjects from Limbang were least likely to be antigen-positive (odds ratio [OR] = 0.23, 95% confidence interval [CI] = 0.12–0.44 versus other sites, P < 0.001). Availability of a flushing toilet was protective against H. pylori carriage (OR = 0.51, 95% CI = 0.27–0.95, P = 0.031). Infection with H. pylori among the Penan was less than reported in other low socioeconomic groups. The lowest prevalence in the most remote setting suggests that the infection has been a recent arrival in previously isolated communities.

Author Notes

Reprint requests: Timothy M. E. Davis, University of Western Australia, School of Medicine and Pharmacology, Fremantle Hospital, PO Box 480, Fremantle, Western Australia 6959, Australia.
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