SHORT REPORT: LACK OF PREDICTION OF AMODIAQUINE EFFICACY IN TREATING PLASMODIUM FALCIPARUM MALARIA BY IN VITRO TESTS

AGNÉS AUBOUY Centre International de Recherches Médicales de Franceville, Unité de Parasitologie Médicale, Franceville, Gabon; Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, le Pharo, Marseille Armées, France; Hôpital de Bakoumba, Bakoumba, Gabon; Hôpital Bichat-Claude Bernard, Laboratoire de Parasitologie, Paris, France; Institut de Recherche pour le Développement, Unité de Recherche 010 Mother and Child Health in the Tropics, Paris, France

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JUSTICE MAYOMBO Centre International de Recherches Médicales de Franceville, Unité de Parasitologie Médicale, Franceville, Gabon; Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, le Pharo, Marseille Armées, France; Hôpital de Bakoumba, Bakoumba, Gabon; Hôpital Bichat-Claude Bernard, Laboratoire de Parasitologie, Paris, France; Institut de Recherche pour le Développement, Unité de Recherche 010 Mother and Child Health in the Tropics, Paris, France

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ANNICK KEUNDJIAN Centre International de Recherches Médicales de Franceville, Unité de Parasitologie Médicale, Franceville, Gabon; Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, le Pharo, Marseille Armées, France; Hôpital de Bakoumba, Bakoumba, Gabon; Hôpital Bichat-Claude Bernard, Laboratoire de Parasitologie, Paris, France; Institut de Recherche pour le Développement, Unité de Recherche 010 Mother and Child Health in the Tropics, Paris, France

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MOHAMED BAKARY Centre International de Recherches Médicales de Franceville, Unité de Parasitologie Médicale, Franceville, Gabon; Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, le Pharo, Marseille Armées, France; Hôpital de Bakoumba, Bakoumba, Gabon; Hôpital Bichat-Claude Bernard, Laboratoire de Parasitologie, Paris, France; Institut de Recherche pour le Développement, Unité de Recherche 010 Mother and Child Health in the Tropics, Paris, France

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JACQUES LE BRAS Centre International de Recherches Médicales de Franceville, Unité de Parasitologie Médicale, Franceville, Gabon; Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, le Pharo, Marseille Armées, France; Hôpital de Bakoumba, Bakoumba, Gabon; Hôpital Bichat-Claude Bernard, Laboratoire de Parasitologie, Paris, France; Institut de Recherche pour le Développement, Unité de Recherche 010 Mother and Child Health in the Tropics, Paris, France

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PHILIPPE DELORON Centre International de Recherches Médicales de Franceville, Unité de Parasitologie Médicale, Franceville, Gabon; Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, le Pharo, Marseille Armées, France; Hôpital de Bakoumba, Bakoumba, Gabon; Hôpital Bichat-Claude Bernard, Laboratoire de Parasitologie, Paris, France; Institut de Recherche pour le Développement, Unité de Recherche 010 Mother and Child Health in the Tropics, Paris, France

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DOI:
https://doi.org/10.4269/ajtmh.2004.71.294
Volume/Issue:
Volume 71: Issue 3
Page(s):
294–296
Restricted access
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Amodiaquine (AQ) is currently a major candidate for new antimalarial combinations, although in vivo and in vitro tests have been rarely simultaneously investigated. The efficacy of AQ was assessed at the dose of 30 mg/kg in treating Plasmodium falciparum malaria attacks in 74 children from southeast Gabon, and the in vitro activity of monodesethylamodiaquine (MdAQ), the main metabolite of AQ, was measured against P. falciparum parasites isolated from these children. Treatment failures were observed in 40.5% of the children, while 5.4% of the isolates showed in vitro resistance to MdAQ. No relationship was observed between in vivo and in vitro susceptibility. The in vitro activities of MdAQ and chloroquine were correlated. The reasons for such disparities between in vivo and in vitro AQ activities are discussed and the issue of the validity of in vitro tests to measure AQ efficacy is raised.

Author Notes

Reprint requests: Philippe Deloron, Institut de Recherche pour le Développement, Unité de Recherche 010, Faculté de Pharmacie, 4 Avenue de l’Observatoire, 75006 Paris, France, Telephone: 33-1-53-73-96-22, Fax: 33-1-53-73-96-17, E-mail: Philippe.Deloron@ird.fr.
Copyright:
Copyright 2004 The American Society of Tropical Medicine 2004
Received:
23 Jan 2004
|
Accepted:
09 Apr 2004
|
Published Online:
Sep 2004
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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