Author:
- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS
- DISCUSSION
ProCite
RefWorks
Reference Manager
BibTeX
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EndNote
-
1
World Health Organization, 2002. Expert Committee. Prevention and Control of Schistosomiasis and Soil-Transmitted Helminthiasis. Geneva: World Health Organization.
-
2
Gryseels B, Mbaye A, de Vlas SJ, Stelma FF, Guisse F, van Lieshout L, Faye D, Diop M, Ly A, Tchuem-Tchuente LA, Engels D, Polman K, 2001. Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence. Trop Med Int Health 6: 864ā873.
-
3
Ismail MM, Metwally AA, Farghally A, Bruce J, Tao LF, Bennett JL, 1996. Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel. Am J Trop Med Hyg 55 :214ā218.
-
4
Ismail M, Botros S, Metwally A, William S, Farghaly A, Tao LF, Day TA, Bennett JL, 1999. Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers. Am J Trop Med Hyg 60 :932ā935.
-
5
Fallon PG, Doenhoff MJ, 1994. Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific. Am J Trop Med Hyg 51 :83ā88.
-
6
Badria F, Abou-Mohamed G, El-Mowafy A, Masoud A, Salama O, 2001. Mirazid: a new schistosomicidal drug. Pharmaceut Biol 93 :127ā131.
-
7
Greene DA, 1993. Gold, frankincense, myrrh, and medicine. N C Med J 54 :620ā622.
-
8
Michie CA, Cooper E, 1991. Frankincense and myrrh as remedies in children. J R Soc Med 84 :602ā605.
-
9
Al-Awadi F, Fatania H, Shamte U, 1991. The effect of a plants mixture extract on liver gluconeogenesis in streptozotocin induced diabetic rats. Diabetes Res 18 :163ā168.
-
10
Claeson P, Andersson R, Samuelsson G, 1991. T-cadinol a pharmacologically active constituent of scented myrrh: introductory pharmacological characterization and high field 1H- and 13C-NMR data. Planta Med 57 :352ā356.
-
11
Sheir Z, Nasr AA, Massoud A, Salama O, Badra GA, El-Shennawy H, Hassan N, Hammad SM, 2001. A safe, effective, herbal anti-schistosomal therapy derived from myrrh. Am J Trop Med Hyg 65 :700ā704.
-
12
Webbe G, James, 1971. The importation and maintenance of schistosomes of human and veterinary importance. Taylor AER, Muller R, eds. Isolation and Maintenance of Parasites In Vivo. Symposia of the British Society for Parasitology. Volume 9. Oxford, United Kingdom: Blackwell Scientific Publications, 77ā107.
-
13
Duvall RH, DeWitt WB, 1967. An improved perfusion technique for recovering adult schistosomes from laboratory animals. Am J Trop Med Hyg 16 :438ā486.
-
14
Pellegrino J, Oliveira CA, Faria J, Cunha A, 1962. New approach to the screening of drugs in experimental Schistosoma mansoni in mice. Am J Trop Med Hyg 11 :201ā215.
-
15
Kloetzel K, 1967. A suggestion for the prevention of severe clinical forms of schistosomiasis mansoni. Bull World Health Organ 37 :686ā687.
-
16
Anonymous, 2002. Problems with dietary supplements. Med Lett 44 :48ā86.
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LACK OF EVIDENCE FOR AN ANTISCHISTOSOMAL ACTIVITY OF MYRRH IN EXPERIMENTAL ANIMALS
SANAA BOTROS
SANAA BOTROS
Theodor Bilharz Research Institute, Giza, Egypt; Institute of Cell Biology, Rome, Italy; Centro de Pesquisas Rene Rachou, MinisteĢrio da Saude, Fiocruz, Belo Horizonte, Minas Gerais, Brazil; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan
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SAMIA WILLIAM
SAMIA WILLIAM
Theodor Bilharz Research Institute, Giza, Egypt; Institute of Cell Biology, Rome, Italy; Centro de Pesquisas Rene Rachou, MinisteĢrio da Saude, Fiocruz, Belo Horizonte, Minas Gerais, Brazil; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan
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FATMA EBEID
FATMA EBEID
Theodor Bilharz Research Institute, Giza, Egypt; Institute of Cell Biology, Rome, Italy; Centro de Pesquisas Rene Rachou, MinisteĢrio da Saude, Fiocruz, Belo Horizonte, Minas Gerais, Brazil; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan
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DONATO CIOLI
DONATO CIOLI
Theodor Bilharz Research Institute, Giza, Egypt; Institute of Cell Biology, Rome, Italy; Centro de Pesquisas Rene Rachou, MinisteĢrio da Saude, Fiocruz, Belo Horizonte, Minas Gerais, Brazil; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan
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NAFTALE KATZ
NAFTALE KATZ
Theodor Bilharz Research Institute, Giza, Egypt; Institute of Cell Biology, Rome, Italy; Centro de Pesquisas Rene Rachou, MinisteĢrio da Saude, Fiocruz, Belo Horizonte, Minas Gerais, Brazil; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan
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TIM A. DAY
TIM A. DAY
Theodor Bilharz Research Institute, Giza, Egypt; Institute of Cell Biology, Rome, Italy; Centro de Pesquisas Rene Rachou, MinisteĢrio da Saude, Fiocruz, Belo Horizonte, Minas Gerais, Brazil; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan
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JAMES L. BENNETT
JAMES L. BENNETT
Theodor Bilharz Research Institute, Giza, Egypt; Institute of Cell Biology, Rome, Italy; Centro de Pesquisas Rene Rachou, MinisteĢrio da Saude, Fiocruz, Belo Horizonte, Minas Gerais, Brazil; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan
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In a multicenter investigation of the potential antischistosomal activity of myrrh, a resin obtained from an African plant, different derivatives of the resin, including the commercial preparation Mirazid, were tested at different doses in mice and hamsters infected with Schistosoma mansoni. In mice infected with the Egyptian (CD) strain of S. mansoni, four of six groups treated with Mirazid did not show significant worm reduction, while the remaining groups showed significant but trivial reductions. In mice infected with the Puerto Rican (Mill Hill) strain of S. mansoni, a Mirazid solution was toxic for mice at high doses and produced modest or no worm reduction at lower doses. In hamsters and mice infected with Puerto Rican (NMRI) and Brazilian (LE) strains of S. mansoni and treated with the crude extract of myrrh in doses ranging from 180 to 10,000 mg/kg, no signs of antibilharzial activity were observed. Total tissue egg load and egg developmental stages were not affected by any of the treatment regimens. These results were in contrast to those obtained in praziquantel-treated animals in which 94% worm reduction and 100% egg reduction was observed. Based on the findings of this work, we cannot recommend the use of Mirazid in human cases of schistosomiasis.
Author Notes
- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS
- DISCUSSION
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
World Health Organization, 2002. Expert Committee. Prevention and Control of Schistosomiasis and Soil-Transmitted Helminthiasis. Geneva: World Health Organization.
-
2
Gryseels B, Mbaye A, de Vlas SJ, Stelma FF, Guisse F, van Lieshout L, Faye D, Diop M, Ly A, Tchuem-Tchuente LA, Engels D, Polman K, 2001. Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence. Trop Med Int Health 6: 864ā873.
-
3
Ismail MM, Metwally AA, Farghally A, Bruce J, Tao LF, Bennett JL, 1996. Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel. Am J Trop Med Hyg 55 :214ā218.
-
4
Ismail M, Botros S, Metwally A, William S, Farghaly A, Tao LF, Day TA, Bennett JL, 1999. Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers. Am J Trop Med Hyg 60 :932ā935.
-
5
Fallon PG, Doenhoff MJ, 1994. Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific. Am J Trop Med Hyg 51 :83ā88.
-
6
Badria F, Abou-Mohamed G, El-Mowafy A, Masoud A, Salama O, 2001. Mirazid: a new schistosomicidal drug. Pharmaceut Biol 93 :127ā131.
-
7
Greene DA, 1993. Gold, frankincense, myrrh, and medicine. N C Med J 54 :620ā622.
-
8
Michie CA, Cooper E, 1991. Frankincense and myrrh as remedies in children. J R Soc Med 84 :602ā605.
-
9
Al-Awadi F, Fatania H, Shamte U, 1991. The effect of a plants mixture extract on liver gluconeogenesis in streptozotocin induced diabetic rats. Diabetes Res 18 :163ā168.
-
10
Claeson P, Andersson R, Samuelsson G, 1991. T-cadinol a pharmacologically active constituent of scented myrrh: introductory pharmacological characterization and high field 1H- and 13C-NMR data. Planta Med 57 :352ā356.
-
11
Sheir Z, Nasr AA, Massoud A, Salama O, Badra GA, El-Shennawy H, Hassan N, Hammad SM, 2001. A safe, effective, herbal anti-schistosomal therapy derived from myrrh. Am J Trop Med Hyg 65 :700ā704.
-
12
Webbe G, James, 1971. The importation and maintenance of schistosomes of human and veterinary importance. Taylor AER, Muller R, eds. Isolation and Maintenance of Parasites In Vivo. Symposia of the British Society for Parasitology. Volume 9. Oxford, United Kingdom: Blackwell Scientific Publications, 77ā107.
-
13
Duvall RH, DeWitt WB, 1967. An improved perfusion technique for recovering adult schistosomes from laboratory animals. Am J Trop Med Hyg 16 :438ā486.
-
14
Pellegrino J, Oliveira CA, Faria J, Cunha A, 1962. New approach to the screening of drugs in experimental Schistosoma mansoni in mice. Am J Trop Med Hyg 11 :201ā215.
-
15
Kloetzel K, 1967. A suggestion for the prevention of severe clinical forms of schistosomiasis mansoni. Bull World Health Organ 37 :686ā687.
-
16
Anonymous, 2002. Problems with dietary supplements. Med Lett 44 :48ā86.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 28 | 28 | 4 |
| Full Text Views | 281 | 86 | 1 |
| PDF Downloads | 47 | 18 | 0 |