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LETTER TO THE EDITOR

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  • 1 Center for Tuberculosis Research
 Johns Hopkins School of Medicine
 Baltimore, MD 21231-1002
 Telephone: 410-614-6600
 Fax: 410-614-8173
 E-mail: ymanabe@jhmi.edu
  • | 2 Department of Molecular Immunology and Microbiology
 Johns Hopkins Bloomberg School of Public Health
 Baltimore, MD 21205
 Telephone: 410-955-7177
 E-mails: chscott@jhsph.edu and nkumar@jhsph.edu
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Dear Sir:

We appreciate the comments of Dr. McKenzie. We are also interested in the other side of the coin; the effect of tuberculosis infection on the course of malaria. In our published series of experiments, there was a suggestion that peak parasitemia occurred slightly earlier in co-infected mice, although the gross pathologic appearance of the co-infected organs showed more hemozoin pigmentation suggesting a higher organ burden of parasites.1 In addition to the data cited by Dr. McKenzie in non-human primates,2,3 results of bacille Calmette-Guérin (BCG) vaccination experiments in mice have shown that BCG vaccination

Dear Sir:

We appreciate the comments of Dr. McKenzie. We are also interested in the other side of the coin; the effect of tuberculosis infection on the course of malaria. In our published series of experiments, there was a suggestion that peak parasitemia occurred slightly earlier in co-infected mice, although the gross pathologic appearance of the co-infected organs showed more hemozoin pigmentation suggesting a higher organ burden of parasites.1 In addition to the data cited by Dr. McKenzie in non-human primates,2,3 results of bacille Calmette-Guérin (BCG) vaccination experiments in mice have shown that BCG vaccination

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