Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
  • 1

    White NJ, 2003. Melioidosis. Lancet 361 :1715–1722.

  • 2

    Reny J, Vuagnat A, Ract C, Benoit M, Safar M, Fagon J, 2002. Diagnosis and follow-up of infections in intensive care patients: value of C-reactive protein compared with other clinical and biological variables. Crit Care Med 30 :529–535.

    • Search Google Scholar
    • Export Citation
  • 3

    Povoa P, 2002. C-reactive protein: a valuable marker of sepsis. Intensive Care Med 28 :235–243.

  • 4

    van Leeuwen MA, van der Heijde DM, van Rijswijk MH, Houtman PM, van Riel PL, van de Putte LB, Limburg PC, 1994. Interrelationship of outcome measures and process variables in early rheumatoid arthritis. A comparison of radiologic damage, physical disability, joint counts, and acute phase reactants. J Rheumatol 21 :425–429.

    • Search Google Scholar
    • Export Citation
  • 5

    Ashdown LR, 1992. Serial serum C-reactive protein levels as an aid to the management of melioidosis. Am J Trop Med Hyg 46 :151–157.

  • 6

    Currie BJ, Fisher DA, Howard DM, Burrow JN, Lo D, Selva-Nayagam S, Anstey NM, Huffam SE, Snelling PL, Marks PJ, Stephens DP, Lum GD, Jacups SP, Krause VL, 2000. Endemic melioidosis in tropical northern Australia: a 10-year prospective study and review of the literature. Clin Infect Dis 31 :981–986.

    • Search Google Scholar
    • Export Citation
  • 7

    ACCP/SCCM, 1992. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20 :864–874.

    • Search Google Scholar
    • Export Citation
  • 8

    Hopstaken RM, Muris JW, Knottnerus JA, Kester AD, Rinkens PE, Dinant GJ, 2003. Contributions of symptoms, signs, erythrocyte sedimentation rate, and C-reactive protein to a diagnosis of pneumonia in acute lower respiratory tract infection. Br J Gen Pract 53 :358–364.

    • Search Google Scholar
    • Export Citation
  • 9

    Smith MD, Suputtamongkol Y, Chaowagul W, Assicot M, Bohuon C, Petitjean S, White NJ, 1995. Elevated serum procalcitonin levels in patients with melioidosis. Clin Infect Dis 20 :641–645.

    • Search Google Scholar
    • Export Citation
  • 10

    Prat C, Dominguez J, Rodrigo C, Gimenez M, Azuara M, Jimenez O, Gali N, Ausina V, Resch B, Gusenleitner W, Muller WD, Luzzani A, Polati E, Dorizzi R, Rungatscher A, Pavan R, Merlini A, 2003. Procalcitonin, C-reactive protein and leukocyte count in children with lower respiratory tract infection. Pediatr Infect Dis J 22 :963–968.

    • Search Google Scholar
    • Export Citation
  • 11

    Resch B, Gusenleitner W, Muller WD, Luzzani A, Polati E, Dorizzi R, Rungatscher A, Pavan R, Merlini A, 2003. Procalcitonin and interleukin-6 in the diagnosis of early-onset sepsis of the neonate. Acta Paediatr 92 :243–245.

    • Search Google Scholar
    • Export Citation
  • 12

    Luzzani A, Polati E, Dorizzi R, Rungatscher A, Pavan R, Merlini A, 2003. Comparison of procalcitonin and C-reactive protein as markers of sepsis. Crit Care Med 31 :1737–1741.

    • Search Google Scholar
    • Export Citation
  • 13

    Friedland JS, Suputtamongkol Y, Remick DG, Chaowagul W, Strieter RM, Kunkel SL, White NJ, Griffin GE, 1992. Prolonged elevation of interleukin-8 and interleukin-6 concentrations in plasma and of leukocyte interleukin-8 mRNA levels during septicemic and localized Pseudomonas pseudomallei infection. Infect Immun 60 :2402–2408.

    • Search Google Scholar
    • Export Citation
  • 14

    Simpson AJ, Smith MD, Weverling GJ, Suputtamongkol Y, Angus BJ, Chaowagul W, White NJ, van Deventer SJ, Prins JM, 2000. Prognostic value of cytokine concentrations (tumor necrosis factor- alpha, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis. J Infect Dis 181 :621–625.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 250 99 0
PDF Downloads 73 28 0
 
 
 
 
 
 
 
 
 
 
 

C-REACTIVE PROTEIN IN THE DIAGNOSIS OF MELIOIDOSIS

ALLEN C. CHENGInfectious Diseases Unit, Menzies School of Health Research, Charles Darwin University, Northern Territory, Australia; Northern Territory Clinical School, Flinders University, Darwin, Australia; Division of Medicine, Royal Darwin Hospital, Darwin, Australia; Faculty of Medicine, University of Melbourne, Melbourne, Australia

Search for other papers by ALLEN C. CHENG in
Current site
Google Scholar
PubMedClose
,
MATTHEW O’BRIENInfectious Diseases Unit, Menzies School of Health Research, Charles Darwin University, Northern Territory, Australia; Northern Territory Clinical School, Flinders University, Darwin, Australia; Division of Medicine, Royal Darwin Hospital, Darwin, Australia; Faculty of Medicine, University of Melbourne, Melbourne, Australia

Search for other papers by MATTHEW O’BRIEN in
Current site
Google Scholar
PubMedClose
,
SUSAN P. JACUPSInfectious Diseases Unit, Menzies School of Health Research, Charles Darwin University, Northern Territory, Australia; Northern Territory Clinical School, Flinders University, Darwin, Australia; Division of Medicine, Royal Darwin Hospital, Darwin, Australia; Faculty of Medicine, University of Melbourne, Melbourne, Australia

Search for other papers by SUSAN P. JACUPS in
Current site
Google Scholar
PubMedClose
,
NICHOLAS M. ANSTEYInfectious Diseases Unit, Menzies School of Health Research, Charles Darwin University, Northern Territory, Australia; Northern Territory Clinical School, Flinders University, Darwin, Australia; Division of Medicine, Royal Darwin Hospital, Darwin, Australia; Faculty of Medicine, University of Melbourne, Melbourne, Australia

Search for other papers by NICHOLAS M. ANSTEY in
Current site
Google Scholar
PubMedClose
, and
BART J. CURRIEInfectious Diseases Unit, Menzies School of Health Research, Charles Darwin University, Northern Territory, Australia; Northern Territory Clinical School, Flinders University, Darwin, Australia; Division of Medicine, Royal Darwin Hospital, Darwin, Australia; Faculty of Medicine, University of Melbourne, Melbourne, Australia

Search for other papers by BART J. CURRIE in
Current site
Google Scholar
PubMedClose
View More View Less
DOI:
https://doi.org/10.4269/ajtmh.2004.70.580
Volume/Issue:
Volume 70: Issue 5
Page(s):
580–582
Restricted access
Get Permissions

Previous work suggested that C-reactive protein (CRP) may be a useful test in the diagnosis of melioidosis, the infection caused by Burkholderia pseudomallei. We reviewed patients with culture-confirmed melioidosis to define the role of this inflammatory marker in the diagnosis of melioidosis. In 175 patients, we found that the admission CRP level may be normal or only mildly elevated, including patients with severe sepsis, fatal cases, and in relapsed melioidosis. In a multivariate analysis, sepsis and bacteremia were more strongly associated with mortality than CRP. Admission levels of CRP are not a sensitive marker for the presence of melioidosis and a normal level cannot be used to exclude acute, chronic, or relapsed melioidosis in febrile patients in or from endemic regions.

Copyright:
Copyright 2004 The American Society of Tropical Medicine 2004
Received:
27 Aug 2003
|
Accepted:
19 Jan 2004
|
Published Online:
May 2004
Save