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Reference Manager
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-
1
Howell C, Jeffers L, Hoofnagle JH, 2000. Hepatitis C in African Americans: Summary of a workshop. Gastroenterology 119 :1385–1396.
-
2
El-Serag HB, 2002. Hepatocellular carcinoma: an epidemiologic view. J Clin Gastroenterol 35 (Suppl 2):S72–S78.
-
3
Mallat DB, Jeffers L, 2002. The natural history of hepatitis C in African Americans. Am J Gastroenterol 97 :520–522.
-
4
Abel-Aziz F, Habib M, Mohamed MK, Abdel-Hamid M, Gamil F, Madkour S, Mikhail NN, Thomas D, Fix AD, Strickland GT, Anwar W, Sallam I, 2000. Hepatitis C infection in a community in the Nile Delta: Population description of HCV prevalence. Hepatology 32 :111–115.
-
5
Khan MH, Farrell GC, Byth K, Lin R, Weltman M, George J, Samarasinghe D, Kench J, Kaba S, Crewe E, Liddle C, 2000. Which patients with hepatitis C develop liver complications. Hepatology 31 :513–520.
-
6
el-Zayadi A, Simmonds P, Dabbous H, Prescott L, Selim O, Ahdy A, 1996. Response to interferon alpha of Egyptian patients infected with hepatitis C virus genotype 4. J Viral Hepat 3 :261–264.
-
7
Larrea E, Garcia N, Qian C, Civeira MP, Prieto J, 1996. Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C. Hepatology 23 :210–217.
-
8
Fukuda R, Ishimura N, Ishihara S, Chowdhury A, Morlyama N, Nogami C, Miyake T, Niigaki M, Tokuda A, Satoh S, Sakai S, Akagi S, Watanabe M, Fukomoto S, 1996. Intrahepatic expression of pro-inflammatory cytokine mRNAs and interferon efficacy in chronic hepatitis C. Liver 16 :390–399.
-
9
Osna N, Silonova G, Vilgert N, Hagina E, Kuse V, Giedraitis V, Zvirbliene A, Mauricas M, Sochnev A, 1997. Chronic hepatitis C: T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood. Scand J Clin Lab Invest 57 :703–710.
-
10
Tsushima H, Kawata S, Tamura S, Ito N, Shirai Y, Kiso S, Doi Y, Yamada A, Oshikawa O, Matsuzawa Y, 1999. Reduced plasma transforming growth factor-beta1 levels in patients with chronic hepatitis C after interferon-alpha therapy: association with regression of hepatic fibrosis. J Hepatol 30 :1–7.
-
11
Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW, 1997. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA 94 :3195–3199.
-
12
Knight JC, Kwiatkowski D, 1999. Inherited variability of tumor necrosis factor production and susceptibility to infectious disease. Proc Assoc Am Physicians 111 :290–298.
-
13
Hohler T, Kruger A, Gerken G, Schneider PM, Meyer zum Buschenfelde KH, Rittner C, 1998. Tumor necrosis factor alpha promoter polymorphism at position −238 is associated with chronic active hepatitis C infection. J Med Virol 54 :173–177.
-
14
Hurme M, Lahdenpohja N, Santtila S, 1998. Gene polymorphisms of interleukins 1 and 10 in infectious and autoimmune diseases. Ann Med 30 :469–473.
-
15
Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV, 1997. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 24 :1–8.
-
16
Awad MR, El-Gamel A, Hasleton P, Turner DM, Sinnott PJ, Hutchinson IV, 1998. Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation. Transplantation 66 :1014–1020.
-
17
Vidigal PG, Germer JJ, Zein NN, 2002. Polymorphisms in the interleukin-10, tumor necrosis factor-α, and transforming growth factor-β1 genes in chronic hepatitis C patients treated with interferon and ribavirin. J Hepatol 36 :271–277.
-
18
Brinkman BM, Huizinga TW, Kurban SS, van der Velde EA, Schreuder GM, Hazes JM, Breedveld FC, Verweij CL, 1997. Tumour necrosis factor alpha gene polymorphisms in rheumatoid arthritis: association with susceptibility to, or severity of, disease? Br J Rheumatol 36 :516–521.
-
19
Hamann A, Mantzoros C, Vidal-Puig A, Flier JS, 1995. Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM). Biochem Biophys Res Comm 211 :833–839.
-
20
D’Alfonso S, Richiardi PM, 1994. A polymorphic variation in a putative regulation box of the TNFA promoter region. Immunogenetics 39 :150–154.
-
21
Zimmerman PA, Guderian RH, Nutman TB, 1996. A new TNFA promoter allele identified in South American Blacks. Immunogenetics 44 :485–486.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 95 | 70 | 22 |
| Full Text Views | 207 | 3 | 1 |
| PDF Downloads | 35 | 3 | 1 |
ETHNIC DIFFERENCES IN POLYMORPHISMS OF TUMOR NECROSIS FACTOR-α, INTERLEUKIN-10, AND TRANSFORMING GROWTH FACTOR-β1 GENES IN PATIENTS WITH CHRONIC HEPATITIS C VIRUS INFECTION
NIZAR N. ZEIN
NIZAR N. ZEIN
Division of Gastroenterology, Hepatology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota; Cairo Liver Center, Cairo, Egypt; School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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JEFFREY J. GERMER
JEFFREY J. GERMER
Division of Gastroenterology, Hepatology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota; Cairo Liver Center, Cairo, Egypt; School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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ABDEL R. EL-ZAYADI
ABDEL R. EL-ZAYADI
Division of Gastroenterology, Hepatology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota; Cairo Liver Center, Cairo, Egypt; School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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PEDRO G. VIDIGAL
PEDRO G. VIDIGAL
Division of Gastroenterology, Hepatology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota; Cairo Liver Center, Cairo, Egypt; School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
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Ethnic differences in the outcome of hepatitis C have been described. Our aim was to investigate ethnic differences in the distribution of genotypes associated with polymorphisms of the tumor necrosis factor-α promoter, interleukin-10 promoter, and transforming growth factor-β1 leader sequence in patients with hepatitis C. Genomic DNA was obtained from 71 Egyptians and 67 Caucasians (hepatitis C and control patients). Amplification of appropriate gene segments was followed by direct sequencing. Infrequently occurring polymorphisms were identified at positions −244 and −77 of the tumor necrosis factor-α promoter and at positions −851 and −657 of the interlukin-10 promoter. The G/A genotype associated with tumor necrosis factor-α promoter positions −376 and −244 was more frequent in Egyptians (P =0.001 and P =0.004, respectively). The −244 G/A genotype occurred only in healthy Egyptians (P =0.024). Thus, ethnic differences in the distribution of genotypes of the tumor necrosis factor-α promoter exist, which may have clinical implications on the outcome of hepatitis C.
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ProCite
RefWorks
Reference Manager
BibTeX
Zotero
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-
1
Howell C, Jeffers L, Hoofnagle JH, 2000. Hepatitis C in African Americans: Summary of a workshop. Gastroenterology 119 :1385–1396.
-
2
El-Serag HB, 2002. Hepatocellular carcinoma: an epidemiologic view. J Clin Gastroenterol 35 (Suppl 2):S72–S78.
-
3
Mallat DB, Jeffers L, 2002. The natural history of hepatitis C in African Americans. Am J Gastroenterol 97 :520–522.
-
4
Abel-Aziz F, Habib M, Mohamed MK, Abdel-Hamid M, Gamil F, Madkour S, Mikhail NN, Thomas D, Fix AD, Strickland GT, Anwar W, Sallam I, 2000. Hepatitis C infection in a community in the Nile Delta: Population description of HCV prevalence. Hepatology 32 :111–115.
-
5
Khan MH, Farrell GC, Byth K, Lin R, Weltman M, George J, Samarasinghe D, Kench J, Kaba S, Crewe E, Liddle C, 2000. Which patients with hepatitis C develop liver complications. Hepatology 31 :513–520.
-
6
el-Zayadi A, Simmonds P, Dabbous H, Prescott L, Selim O, Ahdy A, 1996. Response to interferon alpha of Egyptian patients infected with hepatitis C virus genotype 4. J Viral Hepat 3 :261–264.
-
7
Larrea E, Garcia N, Qian C, Civeira MP, Prieto J, 1996. Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C. Hepatology 23 :210–217.
-
8
Fukuda R, Ishimura N, Ishihara S, Chowdhury A, Morlyama N, Nogami C, Miyake T, Niigaki M, Tokuda A, Satoh S, Sakai S, Akagi S, Watanabe M, Fukomoto S, 1996. Intrahepatic expression of pro-inflammatory cytokine mRNAs and interferon efficacy in chronic hepatitis C. Liver 16 :390–399.
-
9
Osna N, Silonova G, Vilgert N, Hagina E, Kuse V, Giedraitis V, Zvirbliene A, Mauricas M, Sochnev A, 1997. Chronic hepatitis C: T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood. Scand J Clin Lab Invest 57 :703–710.
-
10
Tsushima H, Kawata S, Tamura S, Ito N, Shirai Y, Kiso S, Doi Y, Yamada A, Oshikawa O, Matsuzawa Y, 1999. Reduced plasma transforming growth factor-beta1 levels in patients with chronic hepatitis C after interferon-alpha therapy: association with regression of hepatic fibrosis. J Hepatol 30 :1–7.
-
11
Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW, 1997. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA 94 :3195–3199.
-
12
Knight JC, Kwiatkowski D, 1999. Inherited variability of tumor necrosis factor production and susceptibility to infectious disease. Proc Assoc Am Physicians 111 :290–298.
-
13
Hohler T, Kruger A, Gerken G, Schneider PM, Meyer zum Buschenfelde KH, Rittner C, 1998. Tumor necrosis factor alpha promoter polymorphism at position −238 is associated with chronic active hepatitis C infection. J Med Virol 54 :173–177.
-
14
Hurme M, Lahdenpohja N, Santtila S, 1998. Gene polymorphisms of interleukins 1 and 10 in infectious and autoimmune diseases. Ann Med 30 :469–473.
-
15
Turner DM, Williams DM, Sankaran D, Lazarus M, Sinnott PJ, Hutchinson IV, 1997. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 24 :1–8.
-
16
Awad MR, El-Gamel A, Hasleton P, Turner DM, Sinnott PJ, Hutchinson IV, 1998. Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation. Transplantation 66 :1014–1020.
-
17
Vidigal PG, Germer JJ, Zein NN, 2002. Polymorphisms in the interleukin-10, tumor necrosis factor-α, and transforming growth factor-β1 genes in chronic hepatitis C patients treated with interferon and ribavirin. J Hepatol 36 :271–277.
-
18
Brinkman BM, Huizinga TW, Kurban SS, van der Velde EA, Schreuder GM, Hazes JM, Breedveld FC, Verweij CL, 1997. Tumour necrosis factor alpha gene polymorphisms in rheumatoid arthritis: association with susceptibility to, or severity of, disease? Br J Rheumatol 36 :516–521.
-
19
Hamann A, Mantzoros C, Vidal-Puig A, Flier JS, 1995. Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus (NIDDM). Biochem Biophys Res Comm 211 :833–839.
-
20
D’Alfonso S, Richiardi PM, 1994. A polymorphic variation in a putative regulation box of the TNFA promoter region. Immunogenetics 39 :150–154.
-
21
Zimmerman PA, Guderian RH, Nutman TB, 1996. A new TNFA promoter allele identified in South American Blacks. Immunogenetics 44 :485–486.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 95 | 70 | 22 |
| Full Text Views | 207 | 3 | 1 |
| PDF Downloads | 35 | 3 | 1 |