• 1

    Kidson C, Singhasivanon P, Supavej S, 1999. Mekong Malaria. Southeast Asian J Trop Med Public Health 30 (suppl 4):28–40.

  • 2

    Nosten F, ter Kuile F, Maelankirri L, Decludt B, White NJ, 1991. Malaria during pregnancy in an area of unstable endemicity. Trans R Soc Trop Med Hyg 85 :424–429.

    • Search Google Scholar
    • Export Citation
  • 3

    Nosten F, McGready R, Simpson J, Thwai KL, Balkan S, Cho L, Hkirijareon L, Looareesuwan S, White NJ, 1999. Effects of Plasmodium vivax malaria in pregnanacy. Lancet 14 :546–549.

    • Search Google Scholar
    • Export Citation
  • 4

    Schuurkamp G, Spicer PE, Kereu RK, Bulungol PK, 1992. Chloroquine resistant P. vivax in Papua New Guinea. Trans R Soc Trop Med Hyg 86 :121–122.

    • Search Google Scholar
    • Export Citation
  • 5

    Baird JK, Basri, Purnomo, Bang MJ, Subbianto B, Patchen LC, Hoffmann SL, 1991. Resistance to chloroquine by Plasmodium vivax in Irian Jaya, Indonesia. Am J Trop Med Hyg 44 :547–555.

    • Search Google Scholar
    • Export Citation
  • 6

    Soto J, Toledo J, Gutierrz P, Luzz M, Linas N, Cedeno N, Dunne M, Berman J, 2001. Plasmodium vivax clinically resistant to chloroquine in Colombia. Am J Trop Med Hyg 65 :90–93.

    • Search Google Scholar
    • Export Citation
  • 7

    Dua VK, Kar PK, Sharma VP, 1996. Chloroquine resistant P. vivax malaria in India.Trop Med Int Health 1 :816–819.

  • 8

    Marlar Than, Myat Phone Kyaw, Aye Yu Soe, Khaing Khaing Gyi, Ma Sabai, Myint Oo, 1995. Development of resistance to chloroquine by P. vivax in Myanmar. Trans R Soc Trop Med Hyg 89 :307–308.

    • Search Google Scholar
    • Export Citation
  • 9

    Simpson J, Silamut K, Chotivanich K, Pukrittayakamee S, White NJ, 1999. Red cell selectivity in malaria: a study of multiple infected erythrocytes. Trans R Soc Trop Med Hyg 93 :165–168.

    • Search Google Scholar
    • Export Citation
  • 10

    Silamut K, Hough R, Eggelte T, Pukrittayakamee S, Angus B, White NJ, 1995. A simple method for assessing quinine per-treatment in acute malaria. Trans R Soc Trop Med Hyg 89 :665–667.

    • Search Google Scholar
    • Export Citation
  • 11

    Brockman A, Price R, van Vugt M, Heppner DG, Walsh D, Sookto P, Wimonwattrawatee T, Looareesuwan S, White NJ, Nosten F, 2000. Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunatemefloquine. Trans R Soc Trop Med Hyg 94 :537–544.

    • Search Google Scholar
    • Export Citation
  • 12

    Fevre EM, Barnish G, Yamongul P, Rooney W, 1999. Sensitivity in vitro of Plasmodium falciparum to three currently used antimalarial drugs on the western border of Thailand. Trans R Soc Trop Med Hyg 93 :180–184.

    • Search Google Scholar
    • Export Citation
  • 13

    Childs GE, Pang L, Wimonwattrawatee T, Pooyindee N, Nanakorn A, Limchitee S, Webster HK, 1987. In vitro mefloquine resistance of Plasmodium falciparum isolated from the Burmese border region of Thailand. Southeast Asian J Trop Med Public Health 18 :438–443.

    • Search Google Scholar
    • Export Citation
  • 14

    Pukrittayakamee S, Chantra A, Simpson J, Vanijanonta S, Clemens R, Looareesuwan S, White NJ, 2000. Therapeutic responses to different antimalarial drugs in vivax malaria. Antimicrob Agents Chemother 44 :1680–1685.

    • Search Google Scholar
    • Export Citation
  • 15

    Chulay J, Watkins WM, Sixsmith DG, 1984. Synergistic antimalrial activity of pyrimethamine and sulfadoxine against Plasmodium falciparum in vitro.Am J Trop Med Hyg 33 :325–330.

    • Search Google Scholar
    • Export Citation
  • 16

    Brockelman CR, Tan-Ariya P, 1982. Plasmodium falciparum in continuous culture: a new medium for the in vitro test for sulfadoxine sensitivity. Bull World Health Organ 60 :423–426.

    • Search Google Scholar
    • Export Citation
  • 17

    Wernsdorfer WH, Landgraf B, Wiedermann G, Kollaritsch H, 1995. Chloroquine resistance of Plasmodium falciparum: a biological advantage? Trans R Soc Trop Med Hyg 89 :90–91.

    • Search Google Scholar
    • Export Citation
  • 18

    Tan-Ariya P, Na-Bangchang K, Tin T, Limpaibul L, Brockelman CR, Karbwang J, 1995. Clinical response and susceptibility in vitro of Plasmodim vivax to the standard regimen of chloroquine in Thailand. Trans R Soc Trop Med Hyg 89 :426–429.

    • Search Google Scholar
    • Export Citation

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

IN VITRO EFFICACY OF ANTIMALARIAL DRUGS AGAINST PLASMODIUM VIVAX ON THE WESTERN BORDER OF THAILAND

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  • 1 Faculty of Tropical Medicine, and Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok. Thailand; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom; Mae Sot Hospital, Tak, Thailand

The susceptibility of 20 isolates of Plasmodium vivax on the Thailand-Myanmar border to seven antimalarial drugs was evaluated using the schizont maturation inhibition technique. The geometric mean 50% inhibition concentration (IC50) values were quinine = 308 ng/mL, amodiaquine =14 ng/mL, chloroquine =50 ng/mL, mefloquine = 127 ng/mL, sulfadoxine/pyrimethamine (80:1) = 800/10 ng/mL, pyrimethamine = 8 ng/mL, and artesunate = 0.5 ng/mL. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine.

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