ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Foote SJ, Thompson JK, Cowman AF, Kemp DJ, 1989. Amplification of the multidrug resistance gene in some chloroquine-resistant isolates. Cell 57 :921–930.
-
2
Wilson CM, Scrrano AE, Wasley A, Bogenshutz MP, Shankar AH, Wirth DE, 1989. Amplifications of a gene related to mammalian mdr genes in drug resistant Plasmodium falciparum.Science 244 :1184–1186.
-
3
Wellems TE, Walker-Jonah A, Panton LJ, 1991. Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome. Proc Natl Acad Sci USA 88 :3382–3386.
-
4
Wellems TE, Panton LJ, Gluzman IY, do Rosario VE, Gwadz RW, Walker-Jonah A, Krogstad DJ, 1990. Chloroquine resistance not linked to mdr-like genes in Plasmodium falciparum cross. Nature 345 :253–255.
-
5
Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LMB, Sidhu AS, Naude B, Deitsch KW, Su X-Z, Wootton JC, Roepe PD, Wellems TE, 2000. Mutations in Plasmodium falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell 6 :861–871.
-
6
Mehlotra RK, Fujioka H, Roepe PD, Janneh O, Ursos LMB, Jacobs-Lorena V, Mc Namara DT, Bockarie MJ, Kazura JW, Kyle DE, Fidock DA, Zimmerman PA, 2001. Evolution of a unique Plasmodium falciparum chloroquine resistance phenotype in association with PfCRT polymorphism in Papua New Guinea and South America. Proc Natl Acad Sci USA 98 :12689–12694.
-
7
Djimde A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Diourte Y, Dicko A, Su X-Z, Nomura T, Fidock DA, Wellems TE, Plowe CV, 2001. A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med 344 :257–263.
-
8
Vinayak S, Biswas S, Dev V, Kumar A, Ansari MA, Sharma YD, 2003. Prevalence of K76T mutation in the Pfcrt gene of Plasmodium falciparum among chloroquine responders in India. Acta Trop 87 :287–293.
-
9
Hume JCC, Lyons EJ, Day KP, 2003. Human migration, mosquitoes and the evolution of Plasmodium falciparum.Trends Parasitol 19 :144–149.
-
10
Wootton JC, Feng X, Ferdig MT, Cooper RA, Mu J, Baruch DI, Magill AJ, Su X-Z, 2002. Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum.Nature 418 :320–323.
-
11
Dorsey G, Kamya MR, Singh A, Rosenthal PJ, 2001. Polymorphisms in the Plasmodium falciparum Pfcrt and Pfmdr1 genes and clinical response to chloroquine in Kampala. Uganda J Infect Dis 183 :1417–1420.
-
12
Pillai DR, Labbe A-C, Vanisaveth V, Hongvangthong B, Pomphida S, Inkathone S, Zhong K, Kaln KC, 2001. Plasmodium falciparum malaria in Laos: chloroquine treatment outcome and predictive value of molecular markers. J Infect Dis 183 :789–795.
-
13
Sharma VP, 1997. Resistance to antimalarial drugs in India. Singhal RL, Sood OP, eds. Drug Resistance: Mechanisms and Management. Volume 4. New Delhi: Communicore, 67–72.
-
14
Misra SP, 1996. In vivo resistance to chloroquine and sulfapyrimethamine c ombination in Plasmodium falciparum in India. Proc Natl Acad Sci India 66 :123–138.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2321 | 2100 | 460 |
| Full Text Views | 340 | 19 | 1 |
| PDF Downloads | 120 | 19 | 0 |
WIDESPREAD OCCURRENCE OF THE PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER (PFCRT) GENE HAPLOTYPE SVMNT IN P. FALCIPARUM MALARIA IN INDIA
P. G. VATHSALA
P. G. VATHSALA
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by P. G. VATHSALA in
Current site
Google Scholar
PubMed
Search for other papers by P. G. VATHSALA in
Current site
Google Scholar
PubMed
A. PRAMANIK
A. PRAMANIK
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by A. PRAMANIK in
Current site
Google Scholar
PubMed
Search for other papers by A. PRAMANIK in
Current site
Google Scholar
PubMed
S. DHANASEKARAN
S. DHANASEKARAN
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by S. DHANASEKARAN in
Current site
Google Scholar
PubMed
Search for other papers by S. DHANASEKARAN in
Current site
Google Scholar
PubMed
C. USHA DEVI
C. USHA DEVI
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by C. USHA DEVI in
Current site
Google Scholar
PubMed
Search for other papers by C. USHA DEVI in
Current site
Google Scholar
PubMed
C. R. PILLAI
C. R. PILLAI
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by C. R. PILLAI in
Current site
Google Scholar
PubMed
Search for other papers by C. R. PILLAI in
Current site
Google Scholar
PubMed
S. K. SUBBARAO
S. K. SUBBARAO
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by S. K. SUBBARAO in
Current site
Google Scholar
PubMed
Search for other papers by S. K. SUBBARAO in
Current site
Google Scholar
PubMed
S. K. GHOSH
S. K. GHOSH
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by S. K. GHOSH in
Current site
Google Scholar
PubMed
Search for other papers by S. K. GHOSH in
Current site
Google Scholar
PubMed
S. N. TIWARI
S. N. TIWARI
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by S. N. TIWARI in
Current site
Google Scholar
PubMed
Search for other papers by S. N. TIWARI in
Current site
Google Scholar
PubMed
T. S. SATHYANARAYAN
T. S. SATHYANARAYAN
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by T. S. SATHYANARAYAN in
Current site
Google Scholar
PubMed
Search for other papers by T. S. SATHYANARAYAN in
Current site
Google Scholar
PubMed
P. R. DESHPANDE
P. R. DESHPANDE
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by P. R. DESHPANDE in
Current site
Google Scholar
PubMed
Search for other papers by P. R. DESHPANDE in
Current site
Google Scholar
PubMed
G. C. MISHRA
G. C. MISHRA
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by G. C. MISHRA in
Current site
Google Scholar
PubMed
Search for other papers by G. C. MISHRA in
Current site
Google Scholar
PubMed
M. R. RANJIT
M. R. RANJIT
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by M. R. RANJIT in
Current site
Google Scholar
PubMed
Search for other papers by M. R. RANJIT in
Current site
Google Scholar
PubMed
A. P. DASH
A. P. DASH
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by A. P. DASH in
Current site
Google Scholar
PubMed
Search for other papers by A. P. DASH in
Current site
Google Scholar
PubMed
P. N. RANGARAJAN
P. N. RANGARAJAN
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by P. N. RANGARAJAN in
Current site
Google Scholar
PubMed
Search for other papers by P. N. RANGARAJAN in
Current site
Google Scholar
PubMed
G. PADMANABAN
G. PADMANABAN
Department of Biochemistry, Indian Institute of Science, Bangalore, India; Malaria Research Centre, Delhi, India; Malaria Research Centre, Bangalore, India; National Centre for Cell Science, Pune, India; Regional Medical Research Centre, Bhubaneswar, India; Institute for Life Sciences, Bhubaneswar, India
Search for other papers by G. PADMANABAN in
Current site
Google Scholar
PubMed
Search for other papers by G. PADMANABAN in
Current site
Google Scholar
PubMed
The Plasmodium falciparum chloroquine resistance transporter (Pfcrt) K76T mutation and haplotype (amino acids 72–76) and the P. falciparum multidrug resistance 1 (Pfmdr1) mutation (N86Y) were analyzed as markers of chloroquine resistance in the DNAs of 73 blood samples from patients with P. falciparum malaria in India. Seventy of the 73 DNAs had the Pfcrt K76T mutation. Of these, 66 had the SVMNT haplotype and four had CVIET, the African/Southeast Asian haplotype. Only 20 of 69 DNAs had the Pfmdr1 N86Y mutation. It is surprising that the Pfcrt haplotype in India is predominantly SVMNT, rather than that seen in Southeast Asia. The widespread prevalence of the Pfcrt K76T mutation is a cause for concern.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Foote SJ, Thompson JK, Cowman AF, Kemp DJ, 1989. Amplification of the multidrug resistance gene in some chloroquine-resistant isolates. Cell 57 :921–930.
-
2
Wilson CM, Scrrano AE, Wasley A, Bogenshutz MP, Shankar AH, Wirth DE, 1989. Amplifications of a gene related to mammalian mdr genes in drug resistant Plasmodium falciparum.Science 244 :1184–1186.
-
3
Wellems TE, Walker-Jonah A, Panton LJ, 1991. Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome. Proc Natl Acad Sci USA 88 :3382–3386.
-
4
Wellems TE, Panton LJ, Gluzman IY, do Rosario VE, Gwadz RW, Walker-Jonah A, Krogstad DJ, 1990. Chloroquine resistance not linked to mdr-like genes in Plasmodium falciparum cross. Nature 345 :253–255.
-
5
Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LMB, Sidhu AS, Naude B, Deitsch KW, Su X-Z, Wootton JC, Roepe PD, Wellems TE, 2000. Mutations in Plasmodium falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell 6 :861–871.
-
6
Mehlotra RK, Fujioka H, Roepe PD, Janneh O, Ursos LMB, Jacobs-Lorena V, Mc Namara DT, Bockarie MJ, Kazura JW, Kyle DE, Fidock DA, Zimmerman PA, 2001. Evolution of a unique Plasmodium falciparum chloroquine resistance phenotype in association with PfCRT polymorphism in Papua New Guinea and South America. Proc Natl Acad Sci USA 98 :12689–12694.
-
7
Djimde A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Diourte Y, Dicko A, Su X-Z, Nomura T, Fidock DA, Wellems TE, Plowe CV, 2001. A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med 344 :257–263.
-
8
Vinayak S, Biswas S, Dev V, Kumar A, Ansari MA, Sharma YD, 2003. Prevalence of K76T mutation in the Pfcrt gene of Plasmodium falciparum among chloroquine responders in India. Acta Trop 87 :287–293.
-
9
Hume JCC, Lyons EJ, Day KP, 2003. Human migration, mosquitoes and the evolution of Plasmodium falciparum.Trends Parasitol 19 :144–149.
-
10
Wootton JC, Feng X, Ferdig MT, Cooper RA, Mu J, Baruch DI, Magill AJ, Su X-Z, 2002. Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum.Nature 418 :320–323.
-
11
Dorsey G, Kamya MR, Singh A, Rosenthal PJ, 2001. Polymorphisms in the Plasmodium falciparum Pfcrt and Pfmdr1 genes and clinical response to chloroquine in Kampala. Uganda J Infect Dis 183 :1417–1420.
-
12
Pillai DR, Labbe A-C, Vanisaveth V, Hongvangthong B, Pomphida S, Inkathone S, Zhong K, Kaln KC, 2001. Plasmodium falciparum malaria in Laos: chloroquine treatment outcome and predictive value of molecular markers. J Infect Dis 183 :789–795.
-
13
Sharma VP, 1997. Resistance to antimalarial drugs in India. Singhal RL, Sood OP, eds. Drug Resistance: Mechanisms and Management. Volume 4. New Delhi: Communicore, 67–72.
-
14
Misra SP, 1996. In vivo resistance to chloroquine and sulfapyrimethamine c ombination in Plasmodium falciparum in India. Proc Natl Acad Sci India 66 :123–138.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 2321 | 2100 | 460 |
| Full Text Views | 340 | 19 | 1 |
| PDF Downloads | 120 | 19 | 0 |