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RefWorks
Reference Manager
BibTeX
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-
1
Riley EM, 2000. The London School of Hygiene and Tropical Medicine: a new century of malaria research. Mem Inst Oswaldo Cruz 95 (suppl 1):25–32.
-
2
Yamey G, 2000. African heads of state promise action against malaria. BMJ 320 :1228.
-
3
Yamey G, 2001. Global campaign to eradicate malaria. BMJ 322 :1191–1192.
-
4
World Health Organization and UNICEF, 2003. The Africa Malaria Report 2003. http://mosquito.who.int.
-
5
Bodeker G, Willcox M, 2000. New research initiative on plant-based antimalarials. Lancet 355 :761.
-
6
Hänsel R, Keller K, Rimpler H, Schneider G, 1992. Hagers Handbuch der Pharmazeutischen Praxis. Berlin: Springer Verlag.
-
7
Pharmacopoeia of the People’s Republic of China. Volume 1. English Edition, 2000. Peking: Chemical Industry Press.
-
8
Klayman DL, 1985. Qinghaosu (artemisinin): an antimalarial drug from China. Science 228 :1049–1055.
-
9
de Vries PJ, Dien TK, 1996. Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria. Drugs 52 :818–836.
-
10
Guerin PJ, Olliaro P, Nosten F, Druilhe P, Laxminaraya R, Binka F, Kilama WL, Ford N, White NJ, 2002. Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development. Lancet Infect Dis 2 :564–573.
-
11
McIntosh HM, Olliaro P, 2001. Artemisinin derivatives for treating severe malaria (Cochrane Review). The Cochrane Library 2.Oxford: Update Software.
-
12
Meshnick SR, Taylor TE, Kamchonwongpaisan S, 1996. Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy. Microbiol Rev 60 :301–315.
-
13
World Health Organization, 2001. The Use of Antimalarial Drugs. Geneva: World Health Organization. WHO/CDS/RBM/2001.33.
-
14
Mueller MS, Karhagomba IB, Hirt HM, Wemakor E, 2000. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 73 :487–493.
-
15
Delabays N, Simonnet X, Gaudin M, 2001. The genetics of artemisinin content in Artemisia annua L. and the breeding of high yielding cultivars. Curr Med Chem 8 :1795–1801.
-
16
Zhao SS, Zeng MY, 1985. Studies on the analysis of qinghaosu by high-pressure liquid chromatograph and spectrometry (HPLC). Planta Med 51 :233–237.
-
17
Zhao SS, 1987. High-performance liquid chromatographic determination of artemisinine (qinghaosu) in human plasma and saliva. Analyst 112 :661–664.
-
18
Titulaer HA, Zuidema J, Kager PA, Wetsteyn JC, Lugt CB, Merkus FW, 1990. The pharmacokinetics of artemisinin after oral, intramuscular and rectal administration to volunteers. J Pharm Pharmacol 42 :810–813.
-
19
Edlund PO, Westerlund D, Carlqvist J, Wu BL, Jin YH, 1984. Determination of artesunate and dihydroartemisinine in plasma by liquid chromatography with post-column derivatization and UV-detection. Acta Pharm Suec 21 :223–234.
-
20
Gordi T, Hai TN, Hoai NM, Thyberg M, Ashton M, 2000. Use of saliva and capillary blood samples as substitutes for venous blood sampling in pharmacokinetic investigations of artemisinin. Eur J Clin Pharmacol 56 :561–566.
-
21
Gordi T, Huong DX, Hai TN, Nieu NT, Ashton M, 2002. Artemisinin pharmacokinetics and efficacy in uncomplicated-malaria patients treated with two different dosage regimens. Antimicrob Agents Chemother 46 :1026–1031.
-
22
Svensson US, Alin H, Karlsson MO, Bergqvist Y, Ashton M, 2002. Population pharmacokinetic and pharmacodynamic modelling of artemisinin and mefloquine enantiomers in patients with falciparum malaria. Eur J Clin Pharmacol 58 :339–351.
-
23
Sidhu JS, Ashton M, Huong NV, Hai TN, Karlsson MO, Sy ND, Jonsson EN, Cong LD, 1998. Artemisinin population pharma-cokinetics in children and adults with uncomplicated falciparum malaria. Br J Clin Pharmacol 45 :347–354.
-
24
Alin HM, Ashton M, Kihamia CM, Mtey GJ, Bjorkman A, 1996. Multiple dose pharmacokinetics of oral artemisinin and comparison of its efficacy with that of oral artesunate in falciparum malaria patients. Trans R Soc Trop Med Hyg 90 :61–65.
-
25
Alin MH, Ashton M, Kihamia CM, Mtey GJ, Bjorkman A, 1996. Clinical efficacy and pharmacokinetics of artemisinin monotherapy and in combination with mefloquine in patients with falciparum malaria. Br J Clin Pharmacol 41 :587–592.
-
26
Ashton M, Gordi T, Trinh NH, Nguyen VH, Nguyen DS, Nguyen TN, Dinh XH, Johansson M, Le DC, 1998. Artemisinin pharmacokinetics in healthy adults after 250, 500 and 1000 mg single oral doses. Biopharm Drug Dispos 19 :245–250.
-
27
Ashton M, Hai TN, Sy ND, Huong DX, Van Huong N, Nieu NT, Cong LD, 1998. Artemisinin pharmacokinetics is time-dependent during repeated oral administration in healthy male adults. Drug Metab Dispos 26 :25–27.
-
28
Ashton M, Sy ND, Gordi T, Hai TN, Thach DC, Huong NV, Farah MH, Johansson M, Cong LD, 1996. Evidence for time-dependent artemisinin kinetics in adults with uncomplicated malaria. Pharm Pharmacol Lett 6 :127–130
-
29
Dien TK, de Vries PJ, Khanh NX, Koopmans R, Binh LN, Duc DD, Kager PA, van Boxtel CJ, 1997. Effect of food intake on pharmacokinetics of oral artemisinin in healthy Vietnamese subjects. Antimicrob Agents Chemother 41 :1069–1072.
-
30
Duc DD, de Vries PJ, Nguyen XK, Le Nguyen B, Kager PA, van Boxtel CJ, 1994. The pharmacokinetics of a single dose of artemisinin in healthy Vietnamese subjects. Am J Trop Med Hyg 51 :785–790.
-
31
Alin MH, Bjorkman A, 1994. Concentration and time dependency of artemisinin efficacy against Plasmodium falciparum in vitro. Am J Trop Med Hyg 50 :771–776.
-
32
Gu HM, Warhurst DC, Peters W, 1984. Uptake of [3H] dihydroartemisinine by erythrocytes infected with Plasmodium falciparum in vitro. Trans R Soc Trop Med Hyg 78 :265–270.
-
33
Mueller MS, Runyambo N, Wagner I, Borrmann S, Dietz K, Heide L, 2004. Randomised controlled trial of a traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria. Trans R Soc Trop Med Hyg, in press
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 53 | 53 | 17 |
| Full Text Views | 1035 | 147 | 1 |
| PDF Downloads | 658 | 58 | 0 |
PHARMACOKINETIC STUDY OF ARTEMISININ AFTER ORAL INTAKE OF A TRADITIONAL PREPARATION OF ARTEMISIA ANNUA L. (ANNUAL WORMWOOD)
KARIN RÄTH
KARIN RÄTH
Pharmazeutische Biologie, Pharmazeutisches Institut, Universität Tübingen, Tübingen, Germany; Abteilung für Klinische Pharmakologie, Universitätsklinikum Tübingen, Tübingen, Germany
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KATJA TAXIS
KATJA TAXIS
Pharmazeutische Biologie, Pharmazeutisches Institut, Universität Tübingen, Tübingen, Germany; Abteilung für Klinische Pharmakologie, Universitätsklinikum Tübingen, Tübingen, Germany
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GITTA WALZ
GITTA WALZ
Pharmazeutische Biologie, Pharmazeutisches Institut, Universität Tübingen, Tübingen, Germany; Abteilung für Klinische Pharmakologie, Universitätsklinikum Tübingen, Tübingen, Germany
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CHRISTOPH H. GLEITER
CHRISTOPH H. GLEITER
Pharmazeutische Biologie, Pharmazeutisches Institut, Universität Tübingen, Tübingen, Germany; Abteilung für Klinische Pharmakologie, Universitätsklinikum Tübingen, Tübingen, Germany
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SHU-MING LI
SHU-MING LI
Pharmazeutische Biologie, Pharmazeutisches Institut, Universität Tübingen, Tübingen, Germany; Abteilung für Klinische Pharmakologie, Universitätsklinikum Tübingen, Tübingen, Germany
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LUTZ HEIDE
LUTZ HEIDE
Pharmazeutische Biologie, Pharmazeutisches Institut, Universität Tübingen, Tübingen, Germany; Abteilung für Klinische Pharmakologie, Universitätsklinikum Tübingen, Tübingen, Germany
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Artemisia annua L. (annual wormwood) contains the antimalarial artemisinin. Aqueous preparations of the dried herb are included in the pharmacopoeia of the People’s Republic of China for treatment of fever and malaria. Fourteen healthy male volunteers received one liter of tea prepared from nine grams of Artemisia annua leaves. Blood samples were taken and artemisinin was detected by reversed phase high-performance liquid chromatography. The mean ± SD maximum plasma concentration of artemisinin was 240 ± 75 ng/mL and the mean ± SD area under the plasma concentration-time curve was 336 ± 71 ng/mL × hr. Artemisinin was absorbed faster from herbal tea preparations than from oral solid dosage forms, but bioavailability was similar. One liter of an aqueous preparation of nine grams of Artemisia annua contained 94.5 milligrams of artemisinin (approximately 19% of the usually recommended daily dose). Artemisinin plasma concentrations after intake of this herbal tea are sufficient for clinical effects, but insufficient to recommend such preparations as equivalent substitutes for modern artemisinin drugs in malaria therapy.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Riley EM, 2000. The London School of Hygiene and Tropical Medicine: a new century of malaria research. Mem Inst Oswaldo Cruz 95 (suppl 1):25–32.
-
2
Yamey G, 2000. African heads of state promise action against malaria. BMJ 320 :1228.
-
3
Yamey G, 2001. Global campaign to eradicate malaria. BMJ 322 :1191–1192.
-
4
World Health Organization and UNICEF, 2003. The Africa Malaria Report 2003. http://mosquito.who.int.
-
5
Bodeker G, Willcox M, 2000. New research initiative on plant-based antimalarials. Lancet 355 :761.
-
6
Hänsel R, Keller K, Rimpler H, Schneider G, 1992. Hagers Handbuch der Pharmazeutischen Praxis. Berlin: Springer Verlag.
-
7
Pharmacopoeia of the People’s Republic of China. Volume 1. English Edition, 2000. Peking: Chemical Industry Press.
-
8
Klayman DL, 1985. Qinghaosu (artemisinin): an antimalarial drug from China. Science 228 :1049–1055.
-
9
de Vries PJ, Dien TK, 1996. Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria. Drugs 52 :818–836.
-
10
Guerin PJ, Olliaro P, Nosten F, Druilhe P, Laxminaraya R, Binka F, Kilama WL, Ford N, White NJ, 2002. Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development. Lancet Infect Dis 2 :564–573.
-
11
McIntosh HM, Olliaro P, 2001. Artemisinin derivatives for treating severe malaria (Cochrane Review). The Cochrane Library 2.Oxford: Update Software.
-
12
Meshnick SR, Taylor TE, Kamchonwongpaisan S, 1996. Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy. Microbiol Rev 60 :301–315.
-
13
World Health Organization, 2001. The Use of Antimalarial Drugs. Geneva: World Health Organization. WHO/CDS/RBM/2001.33.
-
14
Mueller MS, Karhagomba IB, Hirt HM, Wemakor E, 2000. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 73 :487–493.
-
15
Delabays N, Simonnet X, Gaudin M, 2001. The genetics of artemisinin content in Artemisia annua L. and the breeding of high yielding cultivars. Curr Med Chem 8 :1795–1801.
-
16
Zhao SS, Zeng MY, 1985. Studies on the analysis of qinghaosu by high-pressure liquid chromatograph and spectrometry (HPLC). Planta Med 51 :233–237.
-
17
Zhao SS, 1987. High-performance liquid chromatographic determination of artemisinine (qinghaosu) in human plasma and saliva. Analyst 112 :661–664.
-
18
Titulaer HA, Zuidema J, Kager PA, Wetsteyn JC, Lugt CB, Merkus FW, 1990. The pharmacokinetics of artemisinin after oral, intramuscular and rectal administration to volunteers. J Pharm Pharmacol 42 :810–813.
-
19
Edlund PO, Westerlund D, Carlqvist J, Wu BL, Jin YH, 1984. Determination of artesunate and dihydroartemisinine in plasma by liquid chromatography with post-column derivatization and UV-detection. Acta Pharm Suec 21 :223–234.
-
20
Gordi T, Hai TN, Hoai NM, Thyberg M, Ashton M, 2000. Use of saliva and capillary blood samples as substitutes for venous blood sampling in pharmacokinetic investigations of artemisinin. Eur J Clin Pharmacol 56 :561–566.
-
21
Gordi T, Huong DX, Hai TN, Nieu NT, Ashton M, 2002. Artemisinin pharmacokinetics and efficacy in uncomplicated-malaria patients treated with two different dosage regimens. Antimicrob Agents Chemother 46 :1026–1031.
-
22
Svensson US, Alin H, Karlsson MO, Bergqvist Y, Ashton M, 2002. Population pharmacokinetic and pharmacodynamic modelling of artemisinin and mefloquine enantiomers in patients with falciparum malaria. Eur J Clin Pharmacol 58 :339–351.
-
23
Sidhu JS, Ashton M, Huong NV, Hai TN, Karlsson MO, Sy ND, Jonsson EN, Cong LD, 1998. Artemisinin population pharma-cokinetics in children and adults with uncomplicated falciparum malaria. Br J Clin Pharmacol 45 :347–354.
-
24
Alin HM, Ashton M, Kihamia CM, Mtey GJ, Bjorkman A, 1996. Multiple dose pharmacokinetics of oral artemisinin and comparison of its efficacy with that of oral artesunate in falciparum malaria patients. Trans R Soc Trop Med Hyg 90 :61–65.
-
25
Alin MH, Ashton M, Kihamia CM, Mtey GJ, Bjorkman A, 1996. Clinical efficacy and pharmacokinetics of artemisinin monotherapy and in combination with mefloquine in patients with falciparum malaria. Br J Clin Pharmacol 41 :587–592.
-
26
Ashton M, Gordi T, Trinh NH, Nguyen VH, Nguyen DS, Nguyen TN, Dinh XH, Johansson M, Le DC, 1998. Artemisinin pharmacokinetics in healthy adults after 250, 500 and 1000 mg single oral doses. Biopharm Drug Dispos 19 :245–250.
-
27
Ashton M, Hai TN, Sy ND, Huong DX, Van Huong N, Nieu NT, Cong LD, 1998. Artemisinin pharmacokinetics is time-dependent during repeated oral administration in healthy male adults. Drug Metab Dispos 26 :25–27.
-
28
Ashton M, Sy ND, Gordi T, Hai TN, Thach DC, Huong NV, Farah MH, Johansson M, Cong LD, 1996. Evidence for time-dependent artemisinin kinetics in adults with uncomplicated malaria. Pharm Pharmacol Lett 6 :127–130
-
29
Dien TK, de Vries PJ, Khanh NX, Koopmans R, Binh LN, Duc DD, Kager PA, van Boxtel CJ, 1997. Effect of food intake on pharmacokinetics of oral artemisinin in healthy Vietnamese subjects. Antimicrob Agents Chemother 41 :1069–1072.
-
30
Duc DD, de Vries PJ, Nguyen XK, Le Nguyen B, Kager PA, van Boxtel CJ, 1994. The pharmacokinetics of a single dose of artemisinin in healthy Vietnamese subjects. Am J Trop Med Hyg 51 :785–790.
-
31
Alin MH, Bjorkman A, 1994. Concentration and time dependency of artemisinin efficacy against Plasmodium falciparum in vitro. Am J Trop Med Hyg 50 :771–776.
-
32
Gu HM, Warhurst DC, Peters W, 1984. Uptake of [3H] dihydroartemisinine by erythrocytes infected with Plasmodium falciparum in vitro. Trans R Soc Trop Med Hyg 78 :265–270.
-
33
Mueller MS, Runyambo N, Wagner I, Borrmann S, Dietz K, Heide L, 2004. Randomised controlled trial of a traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria. Trans R Soc Trop Med Hyg, in press
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 53 | 53 | 17 |
| Full Text Views | 1035 | 147 | 1 |
| PDF Downloads | 658 | 58 | 0 |