Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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DIRECT AGGLUTINATION TEST WITH URINE SAMPLES FOR THE DIAGNOSIS OF VISCERAL LEISHMANIASIS

MOHAMMAD ZAHIDUL ISLAMDepartment of Parasitology, Aichi Medical University School of Medicine, Nagakute, Japan; Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan; Department of Microbiology and Department of Medicine, Rajshahi Medical College, Rajshahi, Bangladesh; Department of Parasitology, Kochi Medical School, Kochi, Japan

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MAKOTO ITOHDepartment of Parasitology, Aichi Medical University School of Medicine, Nagakute, Japan; Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan; Department of Microbiology and Department of Medicine, Rajshahi Medical College, Rajshahi, Bangladesh; Department of Parasitology, Kochi Medical School, Kochi, Japan

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RUSELLA MIRZADepartment of Parasitology, Aichi Medical University School of Medicine, Nagakute, Japan; Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan; Department of Microbiology and Department of Medicine, Rajshahi Medical College, Rajshahi, Bangladesh; Department of Parasitology, Kochi Medical School, Kochi, Japan

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IFTIKHAR AHMEDDepartment of Parasitology, Aichi Medical University School of Medicine, Nagakute, Japan; Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan; Department of Microbiology and Department of Medicine, Rajshahi Medical College, Rajshahi, Bangladesh; Department of Parasitology, Kochi Medical School, Kochi, Japan

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A. R. M. SAIFUDDIN EKRAMDepartment of Parasitology, Aichi Medical University School of Medicine, Nagakute, Japan; Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan; Department of Microbiology and Department of Medicine, Rajshahi Medical College, Rajshahi, Bangladesh; Department of Parasitology, Kochi Medical School, Kochi, Japan

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ABDUL HALIM SARDERDepartment of Parasitology, Aichi Medical University School of Medicine, Nagakute, Japan; Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan; Department of Microbiology and Department of Medicine, Rajshahi Medical College, Rajshahi, Bangladesh; Department of Parasitology, Kochi Medical School, Kochi, Japan

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S. M. SHAMSUZZAMANDepartment of Parasitology, Aichi Medical University School of Medicine, Nagakute, Japan; Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan; Department of Microbiology and Department of Medicine, Rajshahi Medical College, Rajshahi, Bangladesh; Department of Parasitology, Kochi Medical School, Kochi, Japan

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YOSHIHISA HASHIGUCHIDepartment of Parasitology, Aichi Medical University School of Medicine, Nagakute, Japan; Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan; Department of Microbiology and Department of Medicine, Rajshahi Medical College, Rajshahi, Bangladesh; Department of Parasitology, Kochi Medical School, Kochi, Japan

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EISAKU KIMURADepartment of Parasitology, Aichi Medical University School of Medicine, Nagakute, Japan; Department of Endocrinology and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan; Department of Microbiology and Department of Medicine, Rajshahi Medical College, Rajshahi, Bangladesh; Department of Parasitology, Kochi Medical School, Kochi, Japan

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DOI:
https://doi.org/10.4269/ajtmh.2004.70.78
Volume/Issue:
Volume 70: Issue 1
Page(s):
78–82
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A new direct agglutination test (DAT) for use with urine samples for the diagnosis of visceral leishmaniasis (VL) has been developed and compared with the conventional DAT with serum samples and our previously reported enzyme-linked immunosorbent assay (ELISA) with urine samples (urine ELISA). The new DAT, in which anti-human IgG was used as enhancing antibody, was tested with urine samples from 75 VL patients and 225 non-VL patients and healthy people. The sensitivity of the new DAT (90.7%), was almost the same as that of the conventional DAT (91.0%) and the urine ELISA (93.3%). The specificity of the new DAT (96.4%) was nearly identical with that of the urine ELISA (97.3%). A urine-based DAT has several advantages over the conventional DAT: sample collection is non-invasive and it can process larger numbers of samples with smaller amounts of antigen.

Author Notes

Reprint requests: Mohammad Zahidul Islam, Department of Parasitology, Aichi Medical University School of Medicine, Nagakute, Aichi-ken 480-1195, Japan.
Copyright:
Copyright 2004 The American Society of Tropical Medicine 2004
Received:
02 Jul 2003
|
Accepted:
09 Sep 2003
|
Published Online:
Jan 2004
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