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The Development of a Pyrimethamine-Resistant Line of Toxoplasma under in Vitro Conditions
M. Katherine Cook
M. Katherine Cook
National Institute of Allergy and Infectious Diseases, Bethesda 14, Maryland
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Summary
- 1. A pyrimethamine-resistant line of Toxoplasma at least 640 times more resistant than the parent strain was developed in vitro.
- 2. The resistant nature of this line was retained for at least 3 months when the parasite was grown in the absence of pyrimethamine.
- 3. A pyrimethamine-requiring line of Toxoplasma could not be developed.
- 4. The drug-resistant nature of this line of Toxoplasma was not demonstrable in vivo.
Author Notes
Present address: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases.
Laboratory of Tropical Diseases.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 483 | 253 | 16 |
| Full Text Views | 7 | 1 | 0 |
| PDF Downloads | 4 | 2 | 0 |