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-
1
Arlian LG, Morgan MS, Vyszenski-Moher DL, Stemmer BL, 1994. Sarcoptes scabiei: the circulating antibody response and induced immunity to scabies. Exp Parasitol 78 :37–50.
-
2
Arlian LG, Rapp CM, Vyszenski-Moher DL, Morgan MS, 1994. Sarcoptes scabiei: histopathological changes associated with acquisition and expression of host immunity to scabies. Exp Parasitol 78 :51–63.
-
3
Arlian LG, Rapp CM, Stemmer BL, Morgan MS, Moore PF, 1997. Characterization of lymphocyte subtypes in scabietic skin lesions of naïve and sensitized dogs. Vet Parasitol 68 :347–358.
-
4
Burgess I, 1994. Sarcoptes scabiei and Scabies. Baker JR, Muller R, eds. Advances in Parasitology. London: Academic Press Limited, 235–292.
-
5
Bornstein S, Zakrisson G, 1993. Humoral antibody response to experimental Sarcoptes scabiei var. vulpes infection in the dog. Vet Dermatol 4 :107–110.
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6
Bornstein S, Zakrisson G, 1993. Clinical picture and antibody response in pigs infected by Sarcoptes scabiei var. suis.Vet Dermatol 4 :123–131.
-
7
Head ES, Macdonald EM, Ewert A, Apisarnthanarax P, 1990. Sarcoptes scabiei in histopathologic sections of skin in human scabies. Arch Dermatol 126 :1475–1477.
-
8
Hejazi N, Mehregan AH, 1975. Scabies: histological study of inflammatory lesions. Arch Dermatol 111 :37–39.
-
9
Morris DO, Dunstan RW, 1996. A histomorphological study of sarcoptic acariasis in the dog: 19 cases. J Am Anim Hosp Assoc 32 :119–124.
-
10
Morsy GH, Gaafar SM, 1989. Responses of immunoglobulin-secreting cells in the skin of pigs during Sarcoptes scabiei infestation. Vet Parasitol 33 :165–175.
-
11
Stemmer BL, Arlian LG, Morgan MS, Rapp CM, Moore PF, 1996. Characterization of antigen presenting cells and T-cells in progressing scabietic skin lesions. Vet Parasitol 67 :247–258.
-
12
Arlian LG, 1996. Immunology of scabies. Wikel SK, ed. The Immunology of Host-Ectoparasitic Arthropod Relationships. Wallingford, United Kingdom: CAB International, 232–257.
-
13
Arlian LG, 2002. Arthropod allergens and human health. Annu Rev Entomol 47 :395–433.
-
14
Arlian LG, Morgan MS, 2000. Serum antibody to Sarcoptes scabiei and house dust mite prior to and during infestation with S. scabiei.Vet Parasitol 90 :315–326.
-
15
Dahl JC, Scwartz B, Graudal C, Christophersen J, Henrisken SA, 1985. Serum IgE antibodies to the scabies mite. Int J Dermatol 24 :313–315.
-
16
Falk ES, 1980. Serum immunoglobulin values in patients with scabies. Br J Dermatol 102 :57–61.
-
17
Morgan MS, Arlian LG, Estes SA, 1997. Skin test and radioallergosorbent test characteristics of scabietic patients. Am J Trop Med Hyg 57 :190–196.
-
18
Arlian LG, Vyszenski-Moher DL, Rapp CM, Hull BE, 1996. Production of IL-1α and IL-1β by human skin equivalents parasitized by Sarcoptes scabiei.J Parasitol 82 :719–723.
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19
Morgan MS, Arlian LG, 1994. Serum antibody profiles of Sarcoptes scabiei infested or immunized rabbits. Folia Parasitol (Praha) 41 :223–227.
-
20
Bradford MM, 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 :248–254.
-
21
Barton BE, 1997. IL-6: insights into novel biological activities. Clin Immunol Immunopathol 85 :16–20.
-
22
Tilg H, Dinarello CA, Mier JW, 1997. IL-6 and APPs: anti-inflammatory and immnosuppressive mediators. Immunol Today 18 :428–432.
-
23
Van Snick J, 1990. Interleukin-6: an overview. Ann Rev Immunol 8 :253–278.
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24
Mascia F, Mariani V, Giannetti A, Girolomni G, Pastore S, 2002. House dust mite allergen exerts no direct proinflammatory effects on human keratinocytes. J Allergy Clin Immunol 109 :532–538.
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25
Liekens S, De Clercq E, Neyts J, 2001. Angiogenesis: regulators and clinical applications. Biochem Pharmacol 61 :253–270.
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26
Arlian LG, Runyan RA, Vyszenski-Moher DL, 1988. Water balance and nutrient procurement of Sarcoptes scabiei var. canis (Acari: Sarcoptidae). J Med Entomol 25 :64–68.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 167 | 111 | 10 |
| Full Text Views | 294 | 10 | 0 |
| PDF Downloads | 91 | 9 | 0 |
MODULATION OF CYTOKINE EXPRESSION IN HUMAN KERATINOCYTES AND FIBROBLASTS BY EXTRACTS OF SCABIES MITES
LARRY G. ARLIAN
LARRY G. ARLIAN
Department of Biological Sciences, Wright State University, Dayton, Ohio
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MARJORIE S. MORGAN
MARJORIE S. MORGAN
Department of Biological Sciences, Wright State University, Dayton, Ohio
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JACQUELINE S. NEAL
JACQUELINE S. NEAL
Department of Biological Sciences, Wright State University, Dayton, Ohio
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Sarcoptes scabiei lives in the stratum corneum of its mammalian host. Keratinocytes and fibroblasts are among the first cells to encounter the burrowing mite and its products. The aim of this study was to determine if molecules in an extract of S. scabiei modulate the expression of cytokines by keratinocytes and fibroblasts. Human keratinocytes and fibroblasts were exposed to an extract of S. scabiei var. canis in the absence or presence of Escherichia coli lipopolysaccharide. Cytokine expression was measured by an enzyme-linked immunosorbent assay. Components in the S. scabiei extract induced marked increases in secretion of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) and slight increases in production of granulocyte-colony-stimulating factor (G-CSF) by keratinocytes. The scabies extract down-regulated keratinocyte secretion of IL-1 receptor antagonist, but did not influence the production of IL-1α or IL-1β. In comparison, components in the scabies extract induced marked increases in the elaboration of IL-6, IL-8, G-CSF, and VEGF by fibroblasts. Neither cell type produced eotaxin, stem cell factor, or tumor necrosis factor-α under any of the conditions tested. This study demonstrates that components in an extract of the mite S. scabiei are able to influence cytokine expression by human keratinocytes and fibroblasts.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
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-
1
Arlian LG, Morgan MS, Vyszenski-Moher DL, Stemmer BL, 1994. Sarcoptes scabiei: the circulating antibody response and induced immunity to scabies. Exp Parasitol 78 :37–50.
-
2
Arlian LG, Rapp CM, Vyszenski-Moher DL, Morgan MS, 1994. Sarcoptes scabiei: histopathological changes associated with acquisition and expression of host immunity to scabies. Exp Parasitol 78 :51–63.
-
3
Arlian LG, Rapp CM, Stemmer BL, Morgan MS, Moore PF, 1997. Characterization of lymphocyte subtypes in scabietic skin lesions of naïve and sensitized dogs. Vet Parasitol 68 :347–358.
-
4
Burgess I, 1994. Sarcoptes scabiei and Scabies. Baker JR, Muller R, eds. Advances in Parasitology. London: Academic Press Limited, 235–292.
-
5
Bornstein S, Zakrisson G, 1993. Humoral antibody response to experimental Sarcoptes scabiei var. vulpes infection in the dog. Vet Dermatol 4 :107–110.
-
6
Bornstein S, Zakrisson G, 1993. Clinical picture and antibody response in pigs infected by Sarcoptes scabiei var. suis.Vet Dermatol 4 :123–131.
-
7
Head ES, Macdonald EM, Ewert A, Apisarnthanarax P, 1990. Sarcoptes scabiei in histopathologic sections of skin in human scabies. Arch Dermatol 126 :1475–1477.
-
8
Hejazi N, Mehregan AH, 1975. Scabies: histological study of inflammatory lesions. Arch Dermatol 111 :37–39.
-
9
Morris DO, Dunstan RW, 1996. A histomorphological study of sarcoptic acariasis in the dog: 19 cases. J Am Anim Hosp Assoc 32 :119–124.
-
10
Morsy GH, Gaafar SM, 1989. Responses of immunoglobulin-secreting cells in the skin of pigs during Sarcoptes scabiei infestation. Vet Parasitol 33 :165–175.
-
11
Stemmer BL, Arlian LG, Morgan MS, Rapp CM, Moore PF, 1996. Characterization of antigen presenting cells and T-cells in progressing scabietic skin lesions. Vet Parasitol 67 :247–258.
-
12
Arlian LG, 1996. Immunology of scabies. Wikel SK, ed. The Immunology of Host-Ectoparasitic Arthropod Relationships. Wallingford, United Kingdom: CAB International, 232–257.
-
13
Arlian LG, 2002. Arthropod allergens and human health. Annu Rev Entomol 47 :395–433.
-
14
Arlian LG, Morgan MS, 2000. Serum antibody to Sarcoptes scabiei and house dust mite prior to and during infestation with S. scabiei.Vet Parasitol 90 :315–326.
-
15
Dahl JC, Scwartz B, Graudal C, Christophersen J, Henrisken SA, 1985. Serum IgE antibodies to the scabies mite. Int J Dermatol 24 :313–315.
-
16
Falk ES, 1980. Serum immunoglobulin values in patients with scabies. Br J Dermatol 102 :57–61.
-
17
Morgan MS, Arlian LG, Estes SA, 1997. Skin test and radioallergosorbent test characteristics of scabietic patients. Am J Trop Med Hyg 57 :190–196.
-
18
Arlian LG, Vyszenski-Moher DL, Rapp CM, Hull BE, 1996. Production of IL-1α and IL-1β by human skin equivalents parasitized by Sarcoptes scabiei.J Parasitol 82 :719–723.
-
19
Morgan MS, Arlian LG, 1994. Serum antibody profiles of Sarcoptes scabiei infested or immunized rabbits. Folia Parasitol (Praha) 41 :223–227.
-
20
Bradford MM, 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 :248–254.
-
21
Barton BE, 1997. IL-6: insights into novel biological activities. Clin Immunol Immunopathol 85 :16–20.
-
22
Tilg H, Dinarello CA, Mier JW, 1997. IL-6 and APPs: anti-inflammatory and immnosuppressive mediators. Immunol Today 18 :428–432.
-
23
Van Snick J, 1990. Interleukin-6: an overview. Ann Rev Immunol 8 :253–278.
-
24
Mascia F, Mariani V, Giannetti A, Girolomni G, Pastore S, 2002. House dust mite allergen exerts no direct proinflammatory effects on human keratinocytes. J Allergy Clin Immunol 109 :532–538.
-
25
Liekens S, De Clercq E, Neyts J, 2001. Angiogenesis: regulators and clinical applications. Biochem Pharmacol 61 :253–270.
-
26
Arlian LG, Runyan RA, Vyszenski-Moher DL, 1988. Water balance and nutrient procurement of Sarcoptes scabiei var. canis (Acari: Sarcoptidae). J Med Entomol 25 :64–68.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 167 | 111 | 10 |
| Full Text Views | 294 | 10 | 0 |
| PDF Downloads | 91 | 9 | 0 |