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-
1
Ryan ET, Wilson ME, Kain KC, 2002. Illness after international travel. N Engl J Med 347 :505–516.
-
2
Muhlberger N, Jelinek T, Behrens RH, Gjorup I, Coulaud JP, Clerinx J, Puente S, Burchard G, Gascon J, Grobusch MP, Weitzel T, Zoller T, Kollaritsch H, Beran J, Iversen J, Hatz C, Schmid ML, Bjorkman A, Fleischer K, Bisoffi Z, Guggemos W, Knobloch J, Matteelli A, Schulze MA, Laferl H, Kapaun A, McWhinney P, Lopez-Velez R, Fatkenheuer G, Kern P, Zieger BW, Kotlowski A, Fry G, Cuadros J, Myrvang B, 2003. Age as a risk factor for severe manifestations and fatal outcome of falciparum malaria in European patients: observations from TropNetEurop and SIMPID surveillance data. Clin Infect Dis 36 :990–995.
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3
Kain KC, Harrington MA, Tennyson S, Keystone JS, 1998. Imported malaria: prospective analysis of problems in diagnosis and management. Clin Infect Dis 27 :142–149.
-
4
Molyneux M, Fox R, 1993. Diagnosis and treatment of malaria in Britain. BMJ 306 :1175–1180.
-
5
Ohrt C, Purnomo MA, Sutamihardja D, Tang, Kain KC, 2002. Impact of microscopy error on estimates of protective efficacy in malaria-prevention trials. J Infect Dis 186 :540–546.
-
6
Anonymous, 1996. A rapid dipstick antigen capture assay for the diagnosis of falciparum malaria. WHO Informal Consultation on Recent Advances in Diagnostic Techniques and vaccines for Malaria. Bull World Health Organ 74 :47–54.
-
7
Cho Min N, Gatton ML, 2002. Performance appraisal of rapid on-site malaria diagnosis (ICT malaria Pf/Pv test) in relation to human resources at village level in Myanmar. Acta Trop 81 :13–19.
-
8
Gatti S, Bernuzzi AM, Bisoffi Z, Raglio A, Gulletta M, Scaglia M, 2002. Multicentre study, in patients with imported malaria, on the sensitivity and specificity of a dipstick test (ICT Malaria P.f./P.v.) compared with expert microscopy. Ann Trop Med Parasitol 96 :15–18.
-
9
Huong NM, Davis TM, Hewitt S, Huong NV, Uyen TT, Nhan DH, Cong le D, 2002. Comparison of three antigen detection methods for diagnosis and therapeutic monitoring of malaria: a field study from southern Vietnam. Trop Med Int Health 7 :304–308.
-
10
Iqbal J, Khalid N, Hira PR, 2002. Comparison of two commercial assays with expert microscopy for confirmation of symptomatically diagnosed malaria. J Clin Microbiol 40 :4675–4678.
-
11
Mason DP, Kawamoto F, Lin K, Laoboonchai A, Wongsrichanalai C, 2002. A comparison of two rapid field immunochromatographic tests to expert microscopy in the diagnosis of malaria. Acta Trop 82 :51–59.
-
12
Playford EG, Walker J, 2002. Evaluation of the ICT malaria P.f/P.v and the OptiMal rapid diagnostic tests for malaria in febrile returned travelers. J Clin Microbiol 40 :4166–4171.
-
13
Tjitra E, Suprianto S, Dyer M, Currie BJ, Anstey NM, 1999. Field evaluation of the ICT malaria P.f/P.v immunochromatographic test for detection of Plasmodium falciparum and Plasmodium vivax in patients with a presumptive clinical diagnosis of malaria in eastern Indonesia. J Clin Microbiol 37 :2412–2417.
-
14
Pieroni P, Mills CD, Ohrt C, Harrington MA, Kain KC, 1998. Comparison of the ParaSight-F test and the ICT Malaria Pf test with the polymerase chain reaction for the diagnosis of Plasmodium falciparum malaria in travellers. Trans R Soc Trop Med Hyg 92: 166–169.
-
15
Snounou G, Viriyakosol S, Zhu XP, Jarra W, Pinheiro L, do Rosario VE, Thaithong S, Brown KN, 1993. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol Biochem Parasitol 61 :315–320.
-
16
Zhong KJ, Kain KC, 1999. Evaluation of a colorimetric PCR-based assay to diagnose Plasmodium falciparum malaria in travelers. J Clin Microbiol 37 :339–341.
-
17
Brown AE, Kain KC, Pipithkul J, Webster HK, 1992. Demonstration by the polymerase chain reaction of mixed Plasmodium falciparum and P. vivax infections undetected by conventional microscopy. Trans R Soc Trop Med Hyg 86 :609–612.
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18
Humar A, Ohrt C, Harrington MA, Pillai DR, Kain KC, 1997. Parasight F test compared with the polymerase chain reaction and microscopy for the diagnosis of Plasmodium falciparum malaria in travelers. Am J Trop Med Hyg 56 :44–48.
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19
Kain KC, Brown AE, Mirabelli L, Webster HK, 1993. Detection of Plasmodium vivax by polymerase chain reaction in a field study. J Infect Dis 168 :1323–1326.
-
20
Milne LM, Kyi MS, Chiodini PL, Warhurst DC, 1994. Accuracy of routine laboratory diagnosis of malaria in the United Kingdom. J Clin Pathol 47 :740–742.
-
21
Dyer ME, Tjitra E, Currie BJ, Anstey NM, 2000. Failure of the ‘pan-Plasmodium’ antibody of the ICT Malaria P.f/P.v immunochromatographic test to detect symptomatic Plasmodium malariae infection. Trans R Soc Trop Med Hyg 94 :518.
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22
Jelinek T, Grobusch MP, Nothdurft HD, 2000. Use of dipstick tests for the rapid diagnosis of malaria in non-immune travelers. J Travel Med 7 :175–179.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1269 | 1158 | 32 |
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| PDF Downloads | 140 | 21 | 0 |
EVALUATION OF THE BINAX NOW® ICT TEST VERSUS POLYMERASE CHAIN REACTION AND MICROSCOPY FOR THE DETECTION OF MALARIA IN RETURNED TRAVELERS
GABRIELLA A. FARCAS
GABRIELLA A. FARCAS
Institute of Medical Science, Faculty of Medicine University of Toronto, Toronto, Ontario, Canada; Global Health Program, McLaughlin Center for Molecular Medicine, Toronto, Ontario, Canada; Tropical Disease Unit, Division of Infectious Diseases, University Health Network-Toronto General Hospital, Toronto, Ontario, Canada
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KATHLEEN J. Y. ZHONG
KATHLEEN J. Y. ZHONG
Institute of Medical Science, Faculty of Medicine University of Toronto, Toronto, Ontario, Canada; Global Health Program, McLaughlin Center for Molecular Medicine, Toronto, Ontario, Canada; Tropical Disease Unit, Division of Infectious Diseases, University Health Network-Toronto General Hospital, Toronto, Ontario, Canada
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FIONA E. LOVEGROVE
FIONA E. LOVEGROVE
Institute of Medical Science, Faculty of Medicine University of Toronto, Toronto, Ontario, Canada; Global Health Program, McLaughlin Center for Molecular Medicine, Toronto, Ontario, Canada; Tropical Disease Unit, Division of Infectious Diseases, University Health Network-Toronto General Hospital, Toronto, Ontario, Canada
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CHRISTOPHER M. GRAHAM
CHRISTOPHER M. GRAHAM
Institute of Medical Science, Faculty of Medicine University of Toronto, Toronto, Ontario, Canada; Global Health Program, McLaughlin Center for Molecular Medicine, Toronto, Ontario, Canada; Tropical Disease Unit, Division of Infectious Diseases, University Health Network-Toronto General Hospital, Toronto, Ontario, Canada
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KEVIN C. KAIN
KEVIN C. KAIN
Institute of Medical Science, Faculty of Medicine University of Toronto, Toronto, Ontario, Canada; Global Health Program, McLaughlin Center for Molecular Medicine, Toronto, Ontario, Canada; Tropical Disease Unit, Division of Infectious Diseases, University Health Network-Toronto General Hospital, Toronto, Ontario, Canada
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Microscopic detection of Plasmodium species has been the reference standard for the diagnosis of malaria for more than a century. However, maintaining a sufficient level of expertise in microscopic diagnosis can be challenging, particularly in non-endemic countries. The objective of this study was to compare a new rapid malaria diagnostic device (NOW® ICT Malaria Test; Binax, Inc., Portland, ME) to polymerase chain reaction (PCR) and expert microscopy for the diagnosis of malaria in 256 febrile returned travelers. Compared with PCR, the NOW® ICT test showed a sensitivity of 94% for the detection of P. falciparum malaria (96% for pure P. falciparum infection) and 84% for non-P. falciparum infections (87% for pure P. vivax infections and 62% for pure P. ovale and P. malariae infections), with an overall specificity of 99%. The Binax NOW® ICT may represent a useful adjunct for the diagnosis of P. falciparum and P. vivax malaria in febrile returned travelers.
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-
1
Ryan ET, Wilson ME, Kain KC, 2002. Illness after international travel. N Engl J Med 347 :505–516.
-
2
Muhlberger N, Jelinek T, Behrens RH, Gjorup I, Coulaud JP, Clerinx J, Puente S, Burchard G, Gascon J, Grobusch MP, Weitzel T, Zoller T, Kollaritsch H, Beran J, Iversen J, Hatz C, Schmid ML, Bjorkman A, Fleischer K, Bisoffi Z, Guggemos W, Knobloch J, Matteelli A, Schulze MA, Laferl H, Kapaun A, McWhinney P, Lopez-Velez R, Fatkenheuer G, Kern P, Zieger BW, Kotlowski A, Fry G, Cuadros J, Myrvang B, 2003. Age as a risk factor for severe manifestations and fatal outcome of falciparum malaria in European patients: observations from TropNetEurop and SIMPID surveillance data. Clin Infect Dis 36 :990–995.
-
3
Kain KC, Harrington MA, Tennyson S, Keystone JS, 1998. Imported malaria: prospective analysis of problems in diagnosis and management. Clin Infect Dis 27 :142–149.
-
4
Molyneux M, Fox R, 1993. Diagnosis and treatment of malaria in Britain. BMJ 306 :1175–1180.
-
5
Ohrt C, Purnomo MA, Sutamihardja D, Tang, Kain KC, 2002. Impact of microscopy error on estimates of protective efficacy in malaria-prevention trials. J Infect Dis 186 :540–546.
-
6
Anonymous, 1996. A rapid dipstick antigen capture assay for the diagnosis of falciparum malaria. WHO Informal Consultation on Recent Advances in Diagnostic Techniques and vaccines for Malaria. Bull World Health Organ 74 :47–54.
-
7
Cho Min N, Gatton ML, 2002. Performance appraisal of rapid on-site malaria diagnosis (ICT malaria Pf/Pv test) in relation to human resources at village level in Myanmar. Acta Trop 81 :13–19.
-
8
Gatti S, Bernuzzi AM, Bisoffi Z, Raglio A, Gulletta M, Scaglia M, 2002. Multicentre study, in patients with imported malaria, on the sensitivity and specificity of a dipstick test (ICT Malaria P.f./P.v.) compared with expert microscopy. Ann Trop Med Parasitol 96 :15–18.
-
9
Huong NM, Davis TM, Hewitt S, Huong NV, Uyen TT, Nhan DH, Cong le D, 2002. Comparison of three antigen detection methods for diagnosis and therapeutic monitoring of malaria: a field study from southern Vietnam. Trop Med Int Health 7 :304–308.
-
10
Iqbal J, Khalid N, Hira PR, 2002. Comparison of two commercial assays with expert microscopy for confirmation of symptomatically diagnosed malaria. J Clin Microbiol 40 :4675–4678.
-
11
Mason DP, Kawamoto F, Lin K, Laoboonchai A, Wongsrichanalai C, 2002. A comparison of two rapid field immunochromatographic tests to expert microscopy in the diagnosis of malaria. Acta Trop 82 :51–59.
-
12
Playford EG, Walker J, 2002. Evaluation of the ICT malaria P.f/P.v and the OptiMal rapid diagnostic tests for malaria in febrile returned travelers. J Clin Microbiol 40 :4166–4171.
-
13
Tjitra E, Suprianto S, Dyer M, Currie BJ, Anstey NM, 1999. Field evaluation of the ICT malaria P.f/P.v immunochromatographic test for detection of Plasmodium falciparum and Plasmodium vivax in patients with a presumptive clinical diagnosis of malaria in eastern Indonesia. J Clin Microbiol 37 :2412–2417.
-
14
Pieroni P, Mills CD, Ohrt C, Harrington MA, Kain KC, 1998. Comparison of the ParaSight-F test and the ICT Malaria Pf test with the polymerase chain reaction for the diagnosis of Plasmodium falciparum malaria in travellers. Trans R Soc Trop Med Hyg 92: 166–169.
-
15
Snounou G, Viriyakosol S, Zhu XP, Jarra W, Pinheiro L, do Rosario VE, Thaithong S, Brown KN, 1993. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol Biochem Parasitol 61 :315–320.
-
16
Zhong KJ, Kain KC, 1999. Evaluation of a colorimetric PCR-based assay to diagnose Plasmodium falciparum malaria in travelers. J Clin Microbiol 37 :339–341.
-
17
Brown AE, Kain KC, Pipithkul J, Webster HK, 1992. Demonstration by the polymerase chain reaction of mixed Plasmodium falciparum and P. vivax infections undetected by conventional microscopy. Trans R Soc Trop Med Hyg 86 :609–612.
-
18
Humar A, Ohrt C, Harrington MA, Pillai DR, Kain KC, 1997. Parasight F test compared with the polymerase chain reaction and microscopy for the diagnosis of Plasmodium falciparum malaria in travelers. Am J Trop Med Hyg 56 :44–48.
-
19
Kain KC, Brown AE, Mirabelli L, Webster HK, 1993. Detection of Plasmodium vivax by polymerase chain reaction in a field study. J Infect Dis 168 :1323–1326.
-
20
Milne LM, Kyi MS, Chiodini PL, Warhurst DC, 1994. Accuracy of routine laboratory diagnosis of malaria in the United Kingdom. J Clin Pathol 47 :740–742.
-
21
Dyer ME, Tjitra E, Currie BJ, Anstey NM, 2000. Failure of the ‘pan-Plasmodium’ antibody of the ICT Malaria P.f/P.v immunochromatographic test to detect symptomatic Plasmodium malariae infection. Trans R Soc Trop Med Hyg 94 :518.
-
22
Jelinek T, Grobusch MP, Nothdurft HD, 2000. Use of dipstick tests for the rapid diagnosis of malaria in non-immune travelers. J Travel Med 7 :175–179.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1269 | 1158 | 32 |
| Full Text Views | 560 | 18 | 0 |
| PDF Downloads | 140 | 21 | 0 |