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SHORT REPORT: REQUIREMENT OF B CELLS FOR DELAYED TYPE HYPERSENSITIVITY–LIKE PATHOLOGY AFTER SECONDARY INFECTION WITH LEISHMANIA MAJOR IN RESISTANT C57BL/6 MICE
B cell-deficient C57Bl/6 (μMT) mice were resistant to Leishmania major after both primary and secondary parasite challenge. However, unlike in wild-type mice, secondary infection in μMT mice was not accompanied by a marked delayed type hypersensitivity-like response, and interferon-γ (IFN-γ) levels were approximately half of those in wild-type mice. These results suggest that B cells are involved in IFN-γ production and the pathology of secondary infection.