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SHORT REPORT: A MAJOR GENOTYPE OF JAPANESE ENCEPHALITIS VIRUS CURRENTLY CIRCULATING IN JAPAN

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  • 1 Division of Epidemiology, Department of Infectious Diseases, Oita Medical University, Oita, Japan; Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health, Tokyo, Japan; Department of Virology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan; Oita Prefectural Institute of Health and Environment, Oita, Japan

A 240-nucleotide sequence of the capsid/premembrane gene region of 23 Japanese encephalitis virus (JEV) strains isolated in Tokyo and Oita, Japan was determined and phylogenetic analyses were performed. All the strains clustered into two distinct genotypes (III and I). All strains isolated before 1991 belonged to genotype III, while those isolated after 1994 belonged to genotype I. In addition, the strains of the genotype I isolated in Japan showed a close genetic relationship with those from Korea and Malaysia.

Author Notes

Reprint requests: Shao-Ping Ma, Division of Epidemiology, Department of Infectious Diseases, Oita Medical University, Hasamamachi, Oita 879-5593, Japan, Telephone: 81-97-586-5735, Fax: 81-97-586-5739, E-mail: masp@oita-med.ac.jp.
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