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TRANSPLACENTALLY TRANSFERRED MATERNAL-INFANT ANTIBODIES TO DENGUE VIRUS

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  • 1 Department of Pediatrics, Phramongkutklao Hospital, Bangkok, Thailand; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, Maryland

Antibodies of all four dengue virus serotypes were detected by hemagglutination inhibition (HI) in 97% of 2,000 infants’ cord sera at the time of delivery. In comparison with 250 mother–infant’s paired sera, we found that 53% of the infants’ serum HI titers were higher than those of the mother’s. The mother/infant IgG subclasses 1, 2, 3, and 4 titers were 53.1/87.0, 8.4/11.7, 0.14/0.11, and 1.1/1.0 mg/dL, respectively. In 18 months of follow-up of 100 infants studied, we observed that antibody to dengue virus disappeared in 3% by two months of age, in 19% by four months of age, in 72% by six months of age, in 99% by nine months of age, and in 100% by 12 months of age, with a half-life of 41 days. We conclude that the antibodies to dengue virus disappeared in the first year of life. We suggest that the most appropriate age for vaccination with a live-attenuated dengue vaccine in an endemic area is one year of age.

Author Notes

Reprint requests: Veerachai Watanaveeradej, Department of Pediatrics, Phramongkutklao Hospital, 315 Rajavithee Road, Bangkok, Thailand, Telephone and Fax: 66-2-644-8971, e-mail: veerachaiw@yahoo.com.
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