ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Chan BS, 1965. Quantitative changes in the basophil cells of guinea-pig bone marrow following the administration of Ascaris body fluid. Immunology 8 :566–577.
-
2
Chan BS, 1968. Quantitative changes in the basophil cells of guinea-pig bone marrow following the administration of desiccated Ascaris ova. Immunology 14 :99–106.
-
3
Rothwell TL, Love RJ, 1975. Studies of the responses of basophil and eosinophil leucocytes and mast cells to the nematode Trichostrongylus colubriformis. II. Changes in cell numbers following infection of thymectomised and adoptively or passively immunised guinea-pigs. J Pathol 116 :183–194.
-
4
Ogilvie BM, Hesketh PM, Rose ME, 1978. Nippostrongylus brasiliensis: peripheral blood leucocyte response of rats, with special reference to basophils. Exp Parasitol 46 :20–30.
-
5
Roth RL, Levy DA, 1980. Nippostrongylus brasiliensis: peripheral leukocyte responses and correlation of basophils with blood histamine concentration during infection in rats. Exp Parasitol 50 :331–341.
-
6
Kasugai T, Okada M, Morimoto M, Arizono N, Maeyama K, Yamada M, Tei H, Dohmae K, Onoue H, Newlands GF, 1993. Infection of Nippostrongylus brasiliensis induces normal increase of basophils in mast cell-deficient Ws/Ws rats with a small deletion at the kinase domain of c-kit. Blood 81 :2521–2529.
-
7
Okada M, Nawa Y, Horii Y, Kitamura T, Arizono N, 1997. Development of basophils in Mongolian gerbils: formation of basophilic cell clusters in the bone marrow after Nippostrongylus brasiliensis infection. Lab Invest 76 :89–97.
-
8
Ogilvie BM, Askenase PW, Rose ME, 1980. Basophils and eosinophils in three strains of rats and in athymic (nude) rats following infection with the nematodes Nippostrongylus brasiliensis or Trichinella spiralis. Immunology 39 :385–389.
-
9
Lindor LJ, Wassom DL, Gleich GJ, 1983. Effects of trichinellosis on levels of eosinophils, eosinophil major basic protein, creatine kinase and basophils in the guinea pig. Parasite Immunol 5 :13–24.
-
10
Conboy GA, Stromberg BE, 1991. Hematology and clinical pathology of experimental Fascioloides magna infection in cattle and guinea pigs. Vet Parasitol 40 :241–255.
-
11
Harper JS III, Genta RM, Gam A, London WT, Neva FA, 1984. Experimental disseminated strongyloidiasis in Erythrocebus patas. I. Pathology. Am J Trop Med Hyg 33 :431–443.
-
12
Falcone FH, Pritchard DI, Gibbs BF, 2001. Do basophils play a role in immunity against parasites? Trends Parasitol 17 :126–129.
-
13
Wedemeyer J, Tsai M, Galli SJ, 2000. Roles of mast cells and basophils in innate and acquired immunity. Curr Opin Immunol 12 :624–631.
-
14
Ottesen EA, 1985. Parasite infections and allergic reactions: how each affects the other. Weiss EB, Stein M, eds. Bronchial Asthma: Mechanisms and Therapeutics. Second edition. New York: Little, Brown and Co., 522–527.
-
15
Wedemeyer J, Galli SJ, 2000. Mast cells and basophils in acquired immunity. Br Med Bull 56 :936–955.
-
16
Lantz CA, Galli SJ, 1999. Allergy. WE Paul, ed. Fundamental Immunology. Fourth edition. Philadelphia: Lippincott-Raven Publishers, 1155.
-
17
Wakelin D, 1996. Immunity to Parasites. Second edition. Cambridge, United Kingdom: Cambridge University Press.
-
18
Ottesen EA, Nutman TB, 1992. Tropical pulmonary eosinophilia. Annu Rev Med 43 :417–424.
-
19
Rossi CL, Takahashi EE, Partel CD, Teodoro LG, da Silva LJ, 1993. Total serum IgE and parasite-specific IgG and IgA antibodies in human strongyloidiasis. Rev Inst Med Trop Sao Paulo 35 :361–365.
-
20
Estambale BB, Simonsen PE, Vennervald BJ, Knight R, Bwayo JJ, 1995. Bancroftian filariasis in Kwale District of Kenya. III. Quantification of the IgE response in selected individuals from an endemic community. Ann Trop Med Parasitol 89 :287–295.
-
21
Ramirez RM, Ceballos E, Alarcon de Noya B, Noya O, Bianco N, 1996. The immunopathology of human schistosomiasis. III. Immunoglobulin isotype profiles and response to praziquantel. Mem Inst Oswaldo Cruz 91 :593–599.
-
22
Turner H, Kinet JP, 1999. Signalling through the high-affinity IgE receptor Fc–RI. Nature 402 (Suppl): B24–B30.
-
23
Nielsen BW, Lind P, Hansen B, Reimert CM, Nansen P, Schiotz PO, 1994. Immune responses to nematode exoantigens: sensitizing antibodies and basophil histamine release. Allergy 49 :427–435.
-
24
Gonzalez-Munoz M, Garate T, Puente S, Subirats M, Moneo I, 1999. Induction of histamine release in parasitized individuals by somatic and cuticular antigens from Onchocerca volvulus. Am J Trop Med Hyg 60 :974–979.
-
25
Genta RM, Ottesen EA, Poindexter R, Gam AA, Neva FA, Tanowitz HB, Wittner M, 1983. Specific allergic sensitization to Strongyloides antigens in human strongyloidiasis. Lab Invest 48 :633–638.
-
26
Hofstetter M, Fasano MB, Ottesen EA, 1983. Modulation of the host response in human schistosomiasis. IV. Parasite antigen induces release of histamine that inhibits lymphocyte responsiveness in vitro. J Immunol 130 :1376–1380.
-
27
Ottesen EA, Neva FA, Paranjape RS, Tripathy SP, Thiruvengadam KV, Beaven MA, 1979. Specific allergic sensitisation to filarial antigens in tropical eosinophilia syndrome. Lancet 1 :1158–1161.
-
28
King CL, 2001. Transmission intensity and human immune responses to lymphatic filariasis. Parasite Immunol 23 :363–371.
-
29
Falcone FH, Dahinden CA, Gibbs BF, Noll T, Amon U, Hebestreit H, Abrahamsen O, Klaucke J, Schlaak M, Haas H, 1996. Human basophils release interleukin-4 after stimulation with Schistosoma mansoni egg antigen. Eur J Immunol 26 :1147–1155.
-
30
Devouassoux G, Foster B, Scott LM, Metcalfe DD, Prussin C, 1999. Frequency and characterization of antigen-specific IL-4-and IL-13-producing basophils and T cells in peripheral blood of healthy and asthmatic subjects. J Allergy Clin Immunol 104 :811–819.
-
31
Gauchat JF, Henchoz S, Mazzei G, Aubry JP, Brunner T, Blasey H, Life P, Talabot D, Floresromo L, Thompson J, Kishi K, Butterfield J, Dahinden C, Bonnefoy JY, 1993. Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 365 :340–343.
-
32
Haisch K, Schramm G, Falcone FH, Alexander C, Schlaak M, Haas H, 2001. A glycoprotein from Schistosoma mansoni eggs binds non-antigen-specific immunoglobulin E and releases interleukin-4 from human basophils. Parasite Immunol 23 :427–434.
-
33
MacGlashan DW Jr, Bochner BS, Adelman DC, Jardier PM, Togias A, McKenzie-White J, Sterbinsky SA, Hamilton RG, Lichtenstein LM, 1997. Down-regulation of Fc–RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J Immunol 158 :1438–1445.
-
34
Schulte C, Krebs B, Jelinek T, Nothdurft HD, von Sonnenburg F, Loscher T, 2002. Diagnostic significance of blood eosinophilia in returning travelers. Clin Infect Dis 34 :407–411.
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| Abstract Views | 270 | 197 | 11 |
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| PDF Downloads | 127 | 12 | 0 |
LACK OF BASOPHILIA IN HUMAN PARASITIC INFECTIONS
EDWARD MITRE
EDWARD MITRE
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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THOMAS B. NUTMAN
THOMAS B. NUTMAN
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
Search for other papers by THOMAS B. NUTMAN in
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PubMed
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PubMed
While basophilia is often found in animal models of parasitic infection, it has not yet been established whether it occurs in parasite-infected humans. We investigated the relationship between basophilia and parasitic infections in humans by reviewing charts from 668 patients with confirmed parasitic infection (472 with only helminths, 146 with only protozoa, and 50 with both helminth and protozoan infections) and from 50 patients without parasitic infections. Basophilia (> 290 cells/mm3 ) occurred in only four of the 668 parasite-infected patients (0.6%), and there were no statistically significant differences in the percentages of patients with basophilia or in the absolute basophil counts among either the helminth-infected, protozoa-infected, or uninfected populations. Analysis with regard to relative basophil levels revealed that basophils constituted more than 3% of the peripheral white blood cell population in only four patients. Thus, basophilia occurs only rarely in human parasitic infections and is consequently not a useful clinical marker in the evaluation of suspected parasitic disease.
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ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Chan BS, 1965. Quantitative changes in the basophil cells of guinea-pig bone marrow following the administration of Ascaris body fluid. Immunology 8 :566–577.
-
2
Chan BS, 1968. Quantitative changes in the basophil cells of guinea-pig bone marrow following the administration of desiccated Ascaris ova. Immunology 14 :99–106.
-
3
Rothwell TL, Love RJ, 1975. Studies of the responses of basophil and eosinophil leucocytes and mast cells to the nematode Trichostrongylus colubriformis. II. Changes in cell numbers following infection of thymectomised and adoptively or passively immunised guinea-pigs. J Pathol 116 :183–194.
-
4
Ogilvie BM, Hesketh PM, Rose ME, 1978. Nippostrongylus brasiliensis: peripheral blood leucocyte response of rats, with special reference to basophils. Exp Parasitol 46 :20–30.
-
5
Roth RL, Levy DA, 1980. Nippostrongylus brasiliensis: peripheral leukocyte responses and correlation of basophils with blood histamine concentration during infection in rats. Exp Parasitol 50 :331–341.
-
6
Kasugai T, Okada M, Morimoto M, Arizono N, Maeyama K, Yamada M, Tei H, Dohmae K, Onoue H, Newlands GF, 1993. Infection of Nippostrongylus brasiliensis induces normal increase of basophils in mast cell-deficient Ws/Ws rats with a small deletion at the kinase domain of c-kit. Blood 81 :2521–2529.
-
7
Okada M, Nawa Y, Horii Y, Kitamura T, Arizono N, 1997. Development of basophils in Mongolian gerbils: formation of basophilic cell clusters in the bone marrow after Nippostrongylus brasiliensis infection. Lab Invest 76 :89–97.
-
8
Ogilvie BM, Askenase PW, Rose ME, 1980. Basophils and eosinophils in three strains of rats and in athymic (nude) rats following infection with the nematodes Nippostrongylus brasiliensis or Trichinella spiralis. Immunology 39 :385–389.
-
9
Lindor LJ, Wassom DL, Gleich GJ, 1983. Effects of trichinellosis on levels of eosinophils, eosinophil major basic protein, creatine kinase and basophils in the guinea pig. Parasite Immunol 5 :13–24.
-
10
Conboy GA, Stromberg BE, 1991. Hematology and clinical pathology of experimental Fascioloides magna infection in cattle and guinea pigs. Vet Parasitol 40 :241–255.
-
11
Harper JS III, Genta RM, Gam A, London WT, Neva FA, 1984. Experimental disseminated strongyloidiasis in Erythrocebus patas. I. Pathology. Am J Trop Med Hyg 33 :431–443.
-
12
Falcone FH, Pritchard DI, Gibbs BF, 2001. Do basophils play a role in immunity against parasites? Trends Parasitol 17 :126–129.
-
13
Wedemeyer J, Tsai M, Galli SJ, 2000. Roles of mast cells and basophils in innate and acquired immunity. Curr Opin Immunol 12 :624–631.
-
14
Ottesen EA, 1985. Parasite infections and allergic reactions: how each affects the other. Weiss EB, Stein M, eds. Bronchial Asthma: Mechanisms and Therapeutics. Second edition. New York: Little, Brown and Co., 522–527.
-
15
Wedemeyer J, Galli SJ, 2000. Mast cells and basophils in acquired immunity. Br Med Bull 56 :936–955.
-
16
Lantz CA, Galli SJ, 1999. Allergy. WE Paul, ed. Fundamental Immunology. Fourth edition. Philadelphia: Lippincott-Raven Publishers, 1155.
-
17
Wakelin D, 1996. Immunity to Parasites. Second edition. Cambridge, United Kingdom: Cambridge University Press.
-
18
Ottesen EA, Nutman TB, 1992. Tropical pulmonary eosinophilia. Annu Rev Med 43 :417–424.
-
19
Rossi CL, Takahashi EE, Partel CD, Teodoro LG, da Silva LJ, 1993. Total serum IgE and parasite-specific IgG and IgA antibodies in human strongyloidiasis. Rev Inst Med Trop Sao Paulo 35 :361–365.
-
20
Estambale BB, Simonsen PE, Vennervald BJ, Knight R, Bwayo JJ, 1995. Bancroftian filariasis in Kwale District of Kenya. III. Quantification of the IgE response in selected individuals from an endemic community. Ann Trop Med Parasitol 89 :287–295.
-
21
Ramirez RM, Ceballos E, Alarcon de Noya B, Noya O, Bianco N, 1996. The immunopathology of human schistosomiasis. III. Immunoglobulin isotype profiles and response to praziquantel. Mem Inst Oswaldo Cruz 91 :593–599.
-
22
Turner H, Kinet JP, 1999. Signalling through the high-affinity IgE receptor Fc–RI. Nature 402 (Suppl): B24–B30.
-
23
Nielsen BW, Lind P, Hansen B, Reimert CM, Nansen P, Schiotz PO, 1994. Immune responses to nematode exoantigens: sensitizing antibodies and basophil histamine release. Allergy 49 :427–435.
-
24
Gonzalez-Munoz M, Garate T, Puente S, Subirats M, Moneo I, 1999. Induction of histamine release in parasitized individuals by somatic and cuticular antigens from Onchocerca volvulus. Am J Trop Med Hyg 60 :974–979.
-
25
Genta RM, Ottesen EA, Poindexter R, Gam AA, Neva FA, Tanowitz HB, Wittner M, 1983. Specific allergic sensitization to Strongyloides antigens in human strongyloidiasis. Lab Invest 48 :633–638.
-
26
Hofstetter M, Fasano MB, Ottesen EA, 1983. Modulation of the host response in human schistosomiasis. IV. Parasite antigen induces release of histamine that inhibits lymphocyte responsiveness in vitro. J Immunol 130 :1376–1380.
-
27
Ottesen EA, Neva FA, Paranjape RS, Tripathy SP, Thiruvengadam KV, Beaven MA, 1979. Specific allergic sensitisation to filarial antigens in tropical eosinophilia syndrome. Lancet 1 :1158–1161.
-
28
King CL, 2001. Transmission intensity and human immune responses to lymphatic filariasis. Parasite Immunol 23 :363–371.
-
29
Falcone FH, Dahinden CA, Gibbs BF, Noll T, Amon U, Hebestreit H, Abrahamsen O, Klaucke J, Schlaak M, Haas H, 1996. Human basophils release interleukin-4 after stimulation with Schistosoma mansoni egg antigen. Eur J Immunol 26 :1147–1155.
-
30
Devouassoux G, Foster B, Scott LM, Metcalfe DD, Prussin C, 1999. Frequency and characterization of antigen-specific IL-4-and IL-13-producing basophils and T cells in peripheral blood of healthy and asthmatic subjects. J Allergy Clin Immunol 104 :811–819.
-
31
Gauchat JF, Henchoz S, Mazzei G, Aubry JP, Brunner T, Blasey H, Life P, Talabot D, Floresromo L, Thompson J, Kishi K, Butterfield J, Dahinden C, Bonnefoy JY, 1993. Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 365 :340–343.
-
32
Haisch K, Schramm G, Falcone FH, Alexander C, Schlaak M, Haas H, 2001. A glycoprotein from Schistosoma mansoni eggs binds non-antigen-specific immunoglobulin E and releases interleukin-4 from human basophils. Parasite Immunol 23 :427–434.
-
33
MacGlashan DW Jr, Bochner BS, Adelman DC, Jardier PM, Togias A, McKenzie-White J, Sterbinsky SA, Hamilton RG, Lichtenstein LM, 1997. Down-regulation of Fc–RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J Immunol 158 :1438–1445.
-
34
Schulte C, Krebs B, Jelinek T, Nothdurft HD, von Sonnenburg F, Loscher T, 2002. Diagnostic significance of blood eosinophilia in returning travelers. Clin Infect Dis 34 :407–411.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 270 | 197 | 11 |
| Full Text Views | 344 | 5 | 0 |
| PDF Downloads | 127 | 12 | 0 |