• 1

    Desowitz RS, 1989. Plasmodium-specific immunoglobulin E in sera from an area of holoendemic malaria. Trans R Soc Trop Med Hyg 83 :478–479.

    • Search Google Scholar
    • Export Citation
  • 2

    Helmby H, Perlmann H, Troye-Blomberg M, Perlmann P, 1996. Immunoglobulin E elevation in Plasmodium chabaudi malaria. Infect Immun 64 :1432–1433.

    • Search Google Scholar
    • Export Citation
  • 3

    Capron M, Capron A, 1994. Immunoglobulin E and effector cells in schistosomiasis. Science 24 :1876–1877.

  • 4

    Allen J, 1993. Immunology of human helminth infection. Int Arch Allergy Clin Immunol 109 :3–10.

  • 5

    Miller H, 1996. Mucosal mast cells and the allergic response against nematode parasites. Vet Immunol Immunopathol 54 :331–336.

  • 6

    Finkelman F, Holmes J, Katona I, Urban JJ, Beckmann M, Park L, Schooley K, Coffman R, Mosmann T, Paul W, 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol 8 :303–333.

    • Search Google Scholar
    • Export Citation
  • 7

    Punnonen J, Aversa G, Cocks B, McKenzie A, Menon S, Zurawski G, de Waal Malefyt R, de Vries J, 1993. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 90 :3730–3734.

    • Search Google Scholar
    • Export Citation
  • 8

    Perlmann P, Perlmann H, Flyg-Wåhlin B, Hagstedt M, Elghazali G, Worku S, Fernandez V, Rutta A, Troye-Blomberg M, 1997. Immunoglobulin E, a pathogenic factor in Plasmodium falciparum malaria. Infect Immun 65 :116–121.

    • Search Google Scholar
    • Export Citation
  • 9

    Troye-Blomberg M, Riley E, Kabilan L, Holmberg M, Perlmann H, Andersson U, Heusser C, Perlmann P, 1990. Production by activated human T cells of interleukin 4 but not interferon-gamma is associated with elevated levels of serum antibodies to activating malaria antigens. Proc Natl Acad Sci USA 87 :5484–5488.

    • Search Google Scholar
    • Export Citation
  • 10

    Elghazali G, Perlmann H, Rutta A, Perlmann P, Troye-Blomberg M, 1997. Elevated plasma levels of IgE in Plasmodium falciparum-primed individuals reflect an increased ratio of IL-4 to interferon-gamma-producing cells. Clin Exp Immunol 109 :84–89.

    • Search Google Scholar
    • Export Citation
  • 11

    Perlmann H, Helmby H, Hagstedt M, Carlson J, Larsson P, Troye-Blomberg M, Perlmann P, 1994. IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: association of high IgE levels with cerebral malaria. Clin Exp Immunol 97 :284–292.

    • Search Google Scholar
    • Export Citation
  • 12

    Perlmann P, Perlmann H, Looareesuwan S, Krudsood S, Kano S, Matsumoto Y, Brittenham G, Troye-Blomberg M, Aikawa M, 2000. Contrasting functions of IgG and IgE antimalarial antibodies in uncomplicated and severe Plasmodium falciparum malaria. Am J Trop Med Hyg 62 :373–377.

    • Search Google Scholar
    • Export Citation
  • 13

    Maeno Y, Perlmann P, Perlmann H, Kusuhara Y, Taniguchi K, Nakabayashi T, Win K, Looareesuwan S, Aikawa M, 2000. IgE deposition in brain microvessels and on parasitized erythrocytes from cerebral malaria patients. Am J Trop Med Hyg 63 :128–132.

    • Search Google Scholar
    • Export Citation
  • 14

    Berendt A, Simmons D, Tansey J, Newbold C, Marsh K, 1989. Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum.Nature 341 :57–59.

    • Search Google Scholar
    • Export Citation
  • 15

    Hommel M, 1993. Amplification of cytoadherence in cerebral malaria: towards a more rational explanation of disease patho-physiology. Ann Trop Med Parasitol 87 :627–635.

    • Search Google Scholar
    • Export Citation
  • 16

    Grau G, Taylor T, Molyneux M, Wirima J, Vassalli P, Hommel M, Lambert P, 1989. Tumor necrosis factor and disease severity in children with falciparum malaria. N Engl J Med 320 :1586–1591.

    • Search Google Scholar
    • Export Citation
  • 17

    Kwiatkowski D, Hill A, Sambou I, Twumasi P, Castracane J, Manogue K, Cerami A, Brewster D, Greenwood B, 1990. TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet 336 :1201–1204.

    • Search Google Scholar
    • Export Citation
  • 18

    Modiano D, Sirima B, Sawadogo A, Sanou I, Pare J, Konate A, Pagnoni F, 1998. Severe malaria in Burkina Faso: influence of age and transmission level on clinical presentation. Am J Trop Med Hyg 59 :539–542.

    • Search Google Scholar
    • Export Citation
  • 19

    Esposito F, Lombardi S, Modiano D, Zavala F, Reeme J, Lamizana L, Coluzzi M, Nussenzweig R, 1988. Prevalence and levels of antibodies to the circumsporozoite protein of Plasmodium falciparum in an endemic area and their relationship to resistance against malaria infection. Trans R Soc Trop Med Hyg 82 :827–832.

    • Search Google Scholar
    • Export Citation
  • 20

    Sabatinelli G, Bosman A, Lamizana L, Rossi P, 1986. Prevalence of malaria in Ouagadougou and the surrounding rural environment during the period of maximal transmission. Parassitologia 28 :17–31.

    • Search Google Scholar
    • Export Citation
  • 21

    Petrarca V, Petrangeli G, Rossi P, Sabatinelli G, 1986. Chromosomal study of Anopheles gambiae and Anopheles arabiensis in Ouagadougou (Burkina Faso) and various neighboring villages. Parassitologia 28 :41–61.

    • Search Google Scholar
    • Export Citation
  • 22

    Troye-Blomberg M, Perlmann H, Patarroyo M, Perlmann P, 1983. Regulation of the immune response in Plasmodium falciparum malaria. II. Antigen specific proliferative responses in vitro.Clin Exp Immunol 53 :345–353.

    • Search Google Scholar
    • Export Citation
  • 23

    Habluetzel A, Esposito F, Lombardi S, 1989. Immunotechniques for epidemiology of malaria: appropriate tools for integration of primary health care with malaria research and control. Trans R Soc Trop Med Hyg 83 (Suppl):15–19.

    • Search Google Scholar
    • Export Citation
  • 24

    Marsh K, 1992. Malaria–a neglected disease? Parasitology 104 (Suppl):S53–S69.

  • 25

    Cohen S, McGregor I, Carrington S, 1962. Gamma globulin and acquired immunity to human malaria. Nature 192 :733–737.

  • 26

    McGregor I, Carrington S, Cohen S, 1963. Treatment of East African P. falciparum malaria with west African human gamma-globulin. Trans R Soc Trop Med Hyg 57 :170–175.

    • Search Google Scholar
    • Export Citation
  • 27

    Miller L, Good M, Milon G, 1994. Malaria pathogenesis. Science 264 :1878–1883.

  • 28

    Luoni G, Verra B, Arca B, Sirima B, Troye-Blomberg M, Coluzzi M, Kwiatkowski D, Modiano D, 2001. Antimalarial antibody levels and IL-4 polymorphism in the Fulani of West Africa: IL-4 polymorphism and anti-P. falciparum antibody levels. Genes Immun 2 :411–414.

    • Search Google Scholar
    • Export Citation
  • 29

    Desowitz R, Elm J, Alpers M, 1993. Plasmodium falciparum-specific immunoglobulin G (IgG), IgM, and IgE antibodies in paired maternal-cord sera from East Sepik Province, Papua New Guinea. Infect Immun 61 :988–993.

    • Search Google Scholar
    • Export Citation
  • 30

    Maeno Y, Steketee R, Nagatake T, Tegoshi T, Desowitz R, Wirima J, Aikawa M, 1993. Immunoglobulin complex deposits in Plasmodium falciparum-infected placentas from Malawi and Papua New Guinea. Am J Trop Med Hyg 49 :574–580.

    • Search Google Scholar
    • Export Citation
  • 31

    Jarrett E, Miller H, 1982. Production and activities of IgE in helminth infection. Prog Allergy 31 :178–233.

 

 

 

 

IgE ANTIBODIES TO PLASMODIUM FALCIPARUM AND SEVERITY OF MALARIA IN CHILDREN OF ONE ETHNIC GROUP LIVING IN BURKINA FASO

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  • 1 Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome La Sapienza, Rome, Italy; Dipartimento di Scienze di Sanità Publica, Sezione di Parassitologia; Istituto Pasteur Fondazione Cenci Bolognetti, University of Rome La Sapienza, Rome, Italy; Centre National de Recherche et Formation sur le Paludisme, Ministère de la Santé, Ouagadougou, Burkina Faso; Service de Pédiatrie, Centre Hospitalier National Yalgado Ouedraogo,Ouagadougou, Burkina Faso; Department of Immunology, Stockholm University, Stockholm, Sweden

Plasmodium falciparum malaria infection induces elevated blood levels of both total immunoglobulin and anti-plasmodial antibodies belonging to different isotypes. We have previously shown that donors living in areas of malaria transmission develop malaria-specific IgE antibodies that are present at highest concentrations in patients with severe disease, suggesting a role for this isotype in malaria pathogenesis. To establish the possible importance of IgE in the course and severity of this disease, we have analyzed a large and homogenous group of African children (age range = 6 months to 15 years) belonging to one ethnic group (Mossi) living in identical epidemiologic conditions in the same urban area (Ougadougo) of Burkina Faso. While IgG antibodies to P. falciparum increased to high concentrations in very young children and then remained at these levels in older patients, IgE antibodies increased with age, becoming most significantly elevated in children more than four years of age. In older children, those with severe malaria had significantly higher IgE antibody levels than those with non-severe disease. No significant differences between the patient groups were seen for IgG antibodies to P. falciparum. However, when the patients with severe malaria were divided into two groups distinguished by the presence of absence of coma, both IgG and IgE antibodies against malaria were lower in the comatous patients than in the non-comatous patients The results support the conclusion that IgE antibodies against malaria, regardless of their possible protectivity, also contribute to disease severity in this large and homogenous group of African children.

Author Notes

Reprint requests: Marita Troye-Blomberg, The Wenner-Gren Institute, Department of Immunology, Stockholm University, SE-10691 Stockholm, Sweden, Telephone: 46-8-164-164, Fax: 46-8-157-356, E-mail: marita@imun.su.se.
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