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-
1
Chareonviriyaphap T, Bangs MJ, Ratanatham S, 2000. Status of malaria in Thailand. Southeast Asian J Trop Med Public Health 31 :225–237.
-
2
Luxemburger C, Kyaw Ley Thew, White NJ, Webster HK, Kyle DE, Maelankiri L, Chongsuphajaisiddhi T, Nosten F, 1996. The epidemiology of malaria in a Karen population on the western border of Thailand. Trans R Soc Trop Med Hyg 90 :105–111.
-
3
Brockman A, Price RN, van Vugt M, Heppner DG, Walsh D, Sookto P, Wimonwattrawatee T, Looareesuwan S, White NJ, Nosten F, 2000. Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine. Trans R Soc Trop Med Hyg 94 :537–544.
-
4
Looareesuwan S, Olliaro P, White NJ, Chongsuphajaisiddhi T, Sabcharoen A, Thimasarn K, Nosten F, Singhasivanon P, Supavej S, Khusmith S, Wyling S, Kanyok T, Walsh D, Leggat PA, Doberstyn EB, 1998. Consensus recommendation on the treatment of malaria in Southeast Asia. Southeast Asian J Trop Med Public Health 29 :355–360.
-
5
Tanariya P, Na-Bangchang K, Tin T, Limpaibul L, Brockelman CR, Karbwang J, 1995. Clinical response and susceptibility in vitro of Plasmodium vivax to the standard regimen of chloroquine in Thailand. Trans R Soc Trop Med Hyg 89 :426–429.
-
6
Marlar-Tan, Myat-Phone-Kyaw, Aye-Yu-Soe, Khaing-Khaing-Gyi, Ma-Sabai, Myint-Oo, 1995. Development of resistance to chloroquine by Plasmodium vivax in Myanmar. Trans R Soc Trop Med Hyg 89 :307–308.
-
7
Baird JK, Waidy I, Fryauff DJ, Sutanihardja MA, Leksnan B, Widjaya H, Kysdarmanto, Subianto B, 1997. In vivo resistance to chloroquine by Plasmodium vivax and Plasmodium falciparum at Nibire, Irian Jaya, Indonesia. Am J Trop Med Hyg 56 :627–631.
-
8
Looareesuwan S, Wilairatana P, Glanarongran R, Indravijit KA, Supeeranontha L, Chinnapha S, Scott TR, Chulay JD, 1999. Atovaquone and proguanil hydrochloride followed by primaquine for treatment of Plasmodium vivax malaria in Thailand. Trans R Soc Trop Med Hyg 93 :637–640.
-
9
Looareesuwan S, Buchachart K, Wilairatana P, Chalermrut K, Rattanapong Y, Amradee S, Siripipat S, Chullawichit S, Thimasan K, Ittiverakul M, Triampon A, Walsh DS, 1997. Primaquine-tolerant vivax malaria in Thailand. Ann Trop Med Parasitol 91 :939–943.
-
10
Luxemburger C, Nosten F, Kyle DE, Kiricharoen L, Chongsuphajaisiddhi T, White NJ, 1998. Clinical features cannot predict a diagnosis of malaria or differentiate the infecting species in children living in an area of low transmission. Trans R Soc Trop Med Hyg 92 :45–49.
-
11
Mason DP, Krudsood S, Wilairatana P, Viriyavejakul P, Silachamroon U, Chokejindachai W, Singhasivanon P, Supavej S, McKenzie FE, Looareesuwan S, 2001. Can treatment of P. vivax lead to a unexpected appearance of falciparum malaria? Southeast Asian J Trop Med Public Health 32 :57–63.
-
12
Looareesuwan S, White NJ, Chittamas S, Bunnag D, Harinasuta T, 1987. High rate of Plasmodium vivax relapse following treatment of falciparum malaria in Thailand. Lancet ii :1052–1054.
-
13
Krudsood S, Chokejindachai W, Silachamroon U, Phumratanaprapin W, Virayavejakul P, Bussaratid V, Looareesuwan S, 1999. Clinical malaria and treatment of multidrug resistance falciparum in Thailand. Jpn J Trop Med Hyg 27 :181–188.
-
14
Mayxay M, Pukrittayakamee S, Chotivanich K, Imwong M, Looareesuwan S, White NJ, 2001. Identification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria. Am J Trop Med Hyg 65 :588–592.
-
15
Pukrittayakamee S, Chantra A, Simpson JA, Vanijanonta S, Clemens R, Looareesuwan S, White NJ, 2000. Therapeutic responses to different antimalarial drugs in vivax malaria. Antimicrob Agents Chemother 44 :1680–1685.
-
16
Baird JK, Wiady I, Sutanihardija A, Suradi, Purnomo, Basri H, Sekartuti, Ayomi E, Fryauff DJ, Hoffman SL, 2002. Short report: therapeutic efficacy of chloroquine combined with primaquine against Plasmodium falciparum in northeastern Papua, Indonesia. Am J Trop Med Hyg 66 :659–660.
-
17
Nuchprayoon I, Sanpavat S, Nuchprayoon S, 2002. Glucose-6-phosphate dehydrogenase (G6PD) mutations in Thailand: G6PD Viangchan (871G>A) is the most common deficiency variant in the Thai population. Hum Mutat 19 :185.
-
18
Buchachart K, Krudsood S, Singhasivanon P, Treeprasertsuk S, Phophak N, Srivilairit S, Chalermrut K, Rattanapong Y, Supeeranuntha L, Wilairatana P, Brittenham G, Looareesuwan S, 2001. Effect of primaquine standard dose (15 mg/day for 14 days) in the treatment of vivax malaria patients in Thailand. Southeast Asian J Trop Med Public Health 32 :720–726.
-
19
McIntosh HM, Olliaro P, 1998. Treatment of uncomplicated malaria with artemisinin derivatives. A systematic review of randomised controlled trial. Med Trop (Mars) 58 (suppl 3):57–58.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 325 | 275 | 4 |
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CLINICAL TRIAL OF ORAL ARTESUNATE WITH OR WITHOUT HIGH-DOSE PRIMAQUINE FOR THE TREATMENT OF VIVAX MALARIA IN THAILAND
UDOMSAK SILACHAMROON
UDOMSAK SILACHAMROON
Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Wellcome Trust, Mahidol University Oxford Tropical Medicine Research Programme Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Center for Sickle Cell Disease, Howard University, Washington, District of Columbia; College of Physicians and Surgeons, Columbia University, Harkness Pavilion, New York, New York
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SRIVICHA KRUDSOOD
SRIVICHA KRUDSOOD
Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Wellcome Trust, Mahidol University Oxford Tropical Medicine Research Programme Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Center for Sickle Cell Disease, Howard University, Washington, District of Columbia; College of Physicians and Surgeons, Columbia University, Harkness Pavilion, New York, New York
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SOMBAT TREEPRASERTSUK
SOMBAT TREEPRASERTSUK
Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Wellcome Trust, Mahidol University Oxford Tropical Medicine Research Programme Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Center for Sickle Cell Disease, Howard University, Washington, District of Columbia; College of Physicians and Surgeons, Columbia University, Harkness Pavilion, New York, New York
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POLRAT WILAIRATANA
POLRAT WILAIRATANA
Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Wellcome Trust, Mahidol University Oxford Tropical Medicine Research Programme Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Center for Sickle Cell Disease, Howard University, Washington, District of Columbia; College of Physicians and Surgeons, Columbia University, Harkness Pavilion, New York, New York
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KOBSIRI CHALEARMRULT
KOBSIRI CHALEARMRULT
Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Wellcome Trust, Mahidol University Oxford Tropical Medicine Research Programme Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Center for Sickle Cell Disease, Howard University, Washington, District of Columbia; College of Physicians and Surgeons, Columbia University, Harkness Pavilion, New York, New York
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HLA YIN MINT
HLA YIN MINT
Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Wellcome Trust, Mahidol University Oxford Tropical Medicine Research Programme Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Center for Sickle Cell Disease, Howard University, Washington, District of Columbia; College of Physicians and Surgeons, Columbia University, Harkness Pavilion, New York, New York
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PANNAMAS MANEEKAN
PANNAMAS MANEEKAN
Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Wellcome Trust, Mahidol University Oxford Tropical Medicine Research Programme Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Center for Sickle Cell Disease, Howard University, Washington, District of Columbia; College of Physicians and Surgeons, Columbia University, Harkness Pavilion, New York, New York
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NICHOLAS J. WHITE
NICHOLAS J. WHITE
Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Wellcome Trust, Mahidol University Oxford Tropical Medicine Research Programme Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Center for Sickle Cell Disease, Howard University, Washington, District of Columbia; College of Physicians and Surgeons, Columbia University, Harkness Pavilion, New York, New York
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VICTOR R. GOURDEUK
VICTOR R. GOURDEUK
Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Wellcome Trust, Mahidol University Oxford Tropical Medicine Research Programme Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Center for Sickle Cell Disease, Howard University, Washington, District of Columbia; College of Physicians and Surgeons, Columbia University, Harkness Pavilion, New York, New York
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GARY M. BRITTENHAM
GARY M. BRITTENHAM
Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Wellcome Trust, Mahidol University Oxford Tropical Medicine Research Programme Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Center for Sickle Cell Disease, Howard University, Washington, District of Columbia; College of Physicians and Surgeons, Columbia University, Harkness Pavilion, New York, New York
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SORNCHAI LOOAREESUWAN
SORNCHAI LOOAREESUWAN
Department of Clinical Tropical Medicine and Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Wellcome Trust, Mahidol University Oxford Tropical Medicine Research Programme Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Center for Sickle Cell Disease, Howard University, Washington, District of Columbia; College of Physicians and Surgeons, Columbia University, Harkness Pavilion, New York, New York
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We studied prospectively 801 Thai patients admitted to the Bangkok Hospital for Tropical Diseases with acute, symptomatic Plasmodium vivax malaria to determine the optimum duration of treatment with oral artesunate and the safety, tolerability, and effectiveness of a high dose of primaquine in prevention of relapse. Patients were randomly assigned to one of four treatment groups: 1) a five-day course of artesunate (Group A5); 2) a seven-day course of artesunate (Group A7); 3) a five-day course of artesunate plus a 14-day course of high-dose primaquine (0.6 mg/kg, maximum dose = 30 mg) (Group A5 + P); and 4) a seven-day course of artesunate plus a 14-day course of high-dose primaquine (Group A7 + P). During 28 days of observation, P. vivax reappeared in the blood of 50% of those who received artesunate alone (Groups A5 and A7), compared with none of those who received primaquine (Groups A5 + P and A7 + P; P < 0.0001). Adverse effects were confined to the 13 patients with a deficiency for glucose-6-phosphate dehydrogenase; high-dose primaquine (0.6 mg/kg of base a day) had to be stopped in four (31%) patients because of a significant decrease in the hematocrit. The combination of five days of artesunate and 14 days of primaquine is a highly effective and generally well-tolerated treatment regimen for vivax malaria in Thailand.
ProCite
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-
1
Chareonviriyaphap T, Bangs MJ, Ratanatham S, 2000. Status of malaria in Thailand. Southeast Asian J Trop Med Public Health 31 :225–237.
-
2
Luxemburger C, Kyaw Ley Thew, White NJ, Webster HK, Kyle DE, Maelankiri L, Chongsuphajaisiddhi T, Nosten F, 1996. The epidemiology of malaria in a Karen population on the western border of Thailand. Trans R Soc Trop Med Hyg 90 :105–111.
-
3
Brockman A, Price RN, van Vugt M, Heppner DG, Walsh D, Sookto P, Wimonwattrawatee T, Looareesuwan S, White NJ, Nosten F, 2000. Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine. Trans R Soc Trop Med Hyg 94 :537–544.
-
4
Looareesuwan S, Olliaro P, White NJ, Chongsuphajaisiddhi T, Sabcharoen A, Thimasarn K, Nosten F, Singhasivanon P, Supavej S, Khusmith S, Wyling S, Kanyok T, Walsh D, Leggat PA, Doberstyn EB, 1998. Consensus recommendation on the treatment of malaria in Southeast Asia. Southeast Asian J Trop Med Public Health 29 :355–360.
-
5
Tanariya P, Na-Bangchang K, Tin T, Limpaibul L, Brockelman CR, Karbwang J, 1995. Clinical response and susceptibility in vitro of Plasmodium vivax to the standard regimen of chloroquine in Thailand. Trans R Soc Trop Med Hyg 89 :426–429.
-
6
Marlar-Tan, Myat-Phone-Kyaw, Aye-Yu-Soe, Khaing-Khaing-Gyi, Ma-Sabai, Myint-Oo, 1995. Development of resistance to chloroquine by Plasmodium vivax in Myanmar. Trans R Soc Trop Med Hyg 89 :307–308.
-
7
Baird JK, Waidy I, Fryauff DJ, Sutanihardja MA, Leksnan B, Widjaya H, Kysdarmanto, Subianto B, 1997. In vivo resistance to chloroquine by Plasmodium vivax and Plasmodium falciparum at Nibire, Irian Jaya, Indonesia. Am J Trop Med Hyg 56 :627–631.
-
8
Looareesuwan S, Wilairatana P, Glanarongran R, Indravijit KA, Supeeranontha L, Chinnapha S, Scott TR, Chulay JD, 1999. Atovaquone and proguanil hydrochloride followed by primaquine for treatment of Plasmodium vivax malaria in Thailand. Trans R Soc Trop Med Hyg 93 :637–640.
-
9
Looareesuwan S, Buchachart K, Wilairatana P, Chalermrut K, Rattanapong Y, Amradee S, Siripipat S, Chullawichit S, Thimasan K, Ittiverakul M, Triampon A, Walsh DS, 1997. Primaquine-tolerant vivax malaria in Thailand. Ann Trop Med Parasitol 91 :939–943.
-
10
Luxemburger C, Nosten F, Kyle DE, Kiricharoen L, Chongsuphajaisiddhi T, White NJ, 1998. Clinical features cannot predict a diagnosis of malaria or differentiate the infecting species in children living in an area of low transmission. Trans R Soc Trop Med Hyg 92 :45–49.
-
11
Mason DP, Krudsood S, Wilairatana P, Viriyavejakul P, Silachamroon U, Chokejindachai W, Singhasivanon P, Supavej S, McKenzie FE, Looareesuwan S, 2001. Can treatment of P. vivax lead to a unexpected appearance of falciparum malaria? Southeast Asian J Trop Med Public Health 32 :57–63.
-
12
Looareesuwan S, White NJ, Chittamas S, Bunnag D, Harinasuta T, 1987. High rate of Plasmodium vivax relapse following treatment of falciparum malaria in Thailand. Lancet ii :1052–1054.
-
13
Krudsood S, Chokejindachai W, Silachamroon U, Phumratanaprapin W, Virayavejakul P, Bussaratid V, Looareesuwan S, 1999. Clinical malaria and treatment of multidrug resistance falciparum in Thailand. Jpn J Trop Med Hyg 27 :181–188.
-
14
Mayxay M, Pukrittayakamee S, Chotivanich K, Imwong M, Looareesuwan S, White NJ, 2001. Identification of cryptic coinfection with Plasmodium falciparum in patients presenting with vivax malaria. Am J Trop Med Hyg 65 :588–592.
-
15
Pukrittayakamee S, Chantra A, Simpson JA, Vanijanonta S, Clemens R, Looareesuwan S, White NJ, 2000. Therapeutic responses to different antimalarial drugs in vivax malaria. Antimicrob Agents Chemother 44 :1680–1685.
-
16
Baird JK, Wiady I, Sutanihardija A, Suradi, Purnomo, Basri H, Sekartuti, Ayomi E, Fryauff DJ, Hoffman SL, 2002. Short report: therapeutic efficacy of chloroquine combined with primaquine against Plasmodium falciparum in northeastern Papua, Indonesia. Am J Trop Med Hyg 66 :659–660.
-
17
Nuchprayoon I, Sanpavat S, Nuchprayoon S, 2002. Glucose-6-phosphate dehydrogenase (G6PD) mutations in Thailand: G6PD Viangchan (871G>A) is the most common deficiency variant in the Thai population. Hum Mutat 19 :185.
-
18
Buchachart K, Krudsood S, Singhasivanon P, Treeprasertsuk S, Phophak N, Srivilairit S, Chalermrut K, Rattanapong Y, Supeeranuntha L, Wilairatana P, Brittenham G, Looareesuwan S, 2001. Effect of primaquine standard dose (15 mg/day for 14 days) in the treatment of vivax malaria patients in Thailand. Southeast Asian J Trop Med Public Health 32 :720–726.
-
19
McIntosh HM, Olliaro P, 1998. Treatment of uncomplicated malaria with artemisinin derivatives. A systematic review of randomised controlled trial. Med Trop (Mars) 58 (suppl 3):57–58.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 325 | 275 | 4 |
| Full Text Views | 213 | 10 | 0 |
| PDF Downloads | 54 | 13 | 0 |