Author:
- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS
- Establishment of heterologous flavivirus infection(s) in hamsters, their antibody response, and subsequent challenge with YFV.
- Reduced YFV viremia and alteration of liver function in hamsters previously infected with heterologous flaviviruses.
- Histopathologic changes in hamsters challenged with YFV after previous infection with heterologous flaviviruses.
- In situ TUNEL analysis.
- DISCUSSION
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Monath T, 1989. Yellow fever. Monath T, ed. The Arboviruses: Epidemiology and Ecology. Boca Raton, FL: CRC Press, 139–231.
-
2
Monath T, 1997. Epidemiology of yellow fever: current status and speculations on future trends. Saluzzo J, Dodet B, eds. Factors in the Emergence of Arbovirus Diseases. Paris: Elsevier, 143–156.
-
3
Ashcroft MT, 1979. Historical evidence of resistance to yellow fever acquired by residence in India. Trans R Soc Trop Med Hyg 73 :247–248.
-
4
Theiler M, Anderson CR, 1975. The relative resistance of dengue-immune monkeys to yellow fever virus. Am J Trop Med Hyg 24 :115–117.
-
5
Monath TP, Craven RB, Adjukiewicz A, Germain M, Francy DB, Ferrara L, Samba EM, N’Jie H, Cham K, Fitzgerald SA, Crippen PH, Simpson DI, Bowen ET, Fabiyi A, Salaun JJ, 1980. Yellow fever in the Gambia, 1978–1979: epidemiologic aspects with observations on the occurrence of Orungo virus infections. Am J Trop Med Hyg 29 :912–928.
-
6
Henderson BE, Cheshire PP, Kirya GB, Lule M, 1970. Immunologic studies with yellow fever and selected African group B arboviruses in rhesus and vervet monkeys. Am J TropMed Hyg 19 :110–118.
-
7
Tesh RB, Guzman H, da Rosa AP, Vasconcelos PF, Dias LB, Bunnell JE, Zhang H, Xiao SY, 2001. Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus): I. virologic, biochemical and immunologic studies. J Infect Dis 183 :1431–1436.
-
8
Xiao SY, Zhang H, Guzman H, Tesh R, 2001. Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus): II. Pathology. J Infect Dis 183 :1437–1444.
-
9
Hotta S, 1969. Dengue and Related Hemorrhagic Diseases. St. Louis, MO: Warren H. Green.
-
10
Chen B, Wang I, 1974. Studies on attenuated Japanese B encephalitis virus vaccine. 1. Method for obtaining the attenuated 2-8 strain and its biological characteristics. Acta Microbiol Sinica 14 :176–184.
-
11
Xiao S-Y, Guzman H, Zhang H, Travassos da Rosa APA, Tesh RB, 2001. West Nile virus infection in the golden hamster (Mesocricetus auratus): a model of West Nile encephalitis. Emerg Infect Dis 7 :714–721.
-
12
Tesh R, Travassos da Rosa A, Guzman H, Araujo T, Xiao SY, 2002. Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis. Emerg Infect Dis 8 :245–251.
-
13
Reed LJ, Muench H, 1938. A simple method of estimating fifty per cent endpoints. Am J Hyg 27 :493–497.
-
14
Beaty BJ, Calisher C, Shope RE, 1995. Arboviruses. Lennette E, Lennette D, Lennette E, eds. Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections. Seventh edition. Washington, DC: American Public Health Association, 189–212.
-
15
Xiao S-Y, Zhang H, Yang Y, Tesh R, 2001. Pirital virus (Arenaviridae) infection in the Syrian golden hamster, Mesocricetus auratus: a new model for arenaviral hemorrhagic fever. Am J Trop Med Hyg 64 :111–118.
-
16
Kerr J, 1951. The clinical aspects and diagnosis of yellow fever. Strode G, ed. Yellow Fever. New York: McGraw-Hill, 385–425.
-
17
Elton N, Romero A, Trejos A, 1955. Clinical pathology of yellow fever. Am J Clin Pathol 25 :135–146.
-
18
Bugher J, 1951. The pathology of yellow fever. Strode G, ed. Yellow Fever. New York: McGraw-Hill, 137–163.
-
19
Hudson N, 1928. The pathology of experimental yellow fever in the Macacus rhesus. I. Gross pathology. Am J Pathol 4 :395–407.
-
20
Hudson N, 1928. The pathology of experimental yellow fever in the Macacus rhesus. II. Microscopic pathology. Am J Pathol 4 :407–418.
-
21
Hudson N, 1928. The pathology of experimental yellow fever in the Macacus rhesus. III. Comparison with the pathology of yellow fever in man. Am J Pathol 4 :419–439.
-
22
Bearcroft W, 1957. The histopathology of the liver of yellow fever-infected rhesus monkeys. J Pathol Bacteriol 74 :295–303.
-
23
Tigertt W, Berge T, Gochenour WS, Gleiser C, 1960. Experimental yellow fever. Trans NY Acad Sci 22 :323–333.
-
24
La Montaque J, 1983. Summary of a workshop on disease mechanisms and prospects for prevention of Reye’s syndrome. J Infect Dis 148 :943–950.
-
25
Craighead J, 2000. Pathology and Pathogenesis of Human Viral Disease. San Diego: Academic Press.
-
26
Fromenty B, Berson A, Pessayre D, 1997. Microvesicular steatosis an steatohepatitis: role of mitochondrial dysfunction and lipid peroxidation. J Hepatol 26 :13–22.
-
27
Rosser B, Gores GJ, 1995. Liver cell necrosis: cellular mechanisms and clinical implications. Gastroenterology 108 :252–275.
-
28
Lemasters J, Nieminen A, 1997. Mitochondrial oxygen radical formation during reductive and oxidative stress to intact hepatocytes. Biosci Rep 17 :281–291.
-
29
Lemasters J, 1999. Mechanisms of hepatic toxicity. V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis. Am J Physiol 276 :G1–G6.
-
30
Lerat H, Honda M, Beard MR, Loesch K, Sun J, Yang Y, Okuda M, Gosert R, Xiao SY, Weinman SA, Lemon SM, 2002. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 122 :352–365.
-
31
Okuda M, Li K, Beard MR, Showalter LA, Scholle F, Lemon SM, Weinman SA, 2002. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 122 :366–375.
-
32
Dennis LH, Reisberg BE, Crosbie J, Crozier D, Conrad ME, 1969. The original haemorrhagic fever: yellow fever. Br J Haematol 17 :455–462.
-
33
Halstead S, 1988. Pathogenesis of dengue: challenges to molecular biology. Science 239 :476–481.
-
34
Kliks S, Nisalak A, Brandt W, Wahl L, Burke D, 1989. Antibody dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever. Am J Trop Med Hyg 40 :444–451.
-
35
Roehrig J, 1997. Immunochemistry of dengue viruses. Gubler D, Kuno G, eds. Dengue and Dengue Hemorrhagic Fever. New York: CAB International, 199–219.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 21 | 21 | 8 |
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ALTERATION OF CLINICAL OUTCOME AND HISTOPATHOLOGY OF YELLOW FEVER VIRUS INFECTION IN A HAMSTER MODEL BY PREVIOUS INFECTION WITH HETEROLOGOUS FLAVIVIRUSES
SHU-YUAN XIAO
SHU-YUAN XIAO
Department of Pathology and Center for Tropical Diseases, and Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas
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HILDA GUZMAN
HILDA GUZMAN
Department of Pathology and Center for Tropical Diseases, and Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas
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AMELIA P. A. TRAVASSOS DA ROSA
AMELIA P. A. TRAVASSOS DA ROSA
Department of Pathology and Center for Tropical Diseases, and Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas
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HONG-BING ZHU
HONG-BING ZHU
Department of Pathology and Center for Tropical Diseases, and Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas
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ROBERT B. TESH
ROBERT B. TESH
Department of Pathology and Center for Tropical Diseases, and Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas
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Using a recently described hamster model of severe yellow fever (YF), we examined the hypothesis that prior infection with heterologous flaviviruses protects against severe or fatal YF. Hamsters were singly or sequentially infected with Japanese encephalitis, St. Louis encephalitis, West Nile, and/or dengue-1 viruses, and then challenged with a virulent strain of yellow fever virus (YFV). In contrast to control (naive) hamsters, many of which appeared clinically ill or died after YFV infection, the flavivirus-immune animals remained asymptomatic. The flavivirus-immune hamsters also had a reduced viremia and lower serum levels of alanine aminotransferase and total bilirubin, compared with naive hamsters, following YFV infection. Histologically, livers of animals in the flavivirus-immune and control groups showed comparable levels of multifocal necrapoptosis. However, steatosis was not observed in the flavivirus-immune animals, whereas naive hamsters developed extensive microvesicular steatosis in the liver following YFV infection. These findings suggest that hepatocytic steatosis is an adverse microscopic feature associated with severe disease in YFV infection. Our experimental results support earlier anecdotal reports that prior exposure of humans to heterologous flaviviruses reduces subsequent risk of fatal YFV infection.
- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS
- Establishment of heterologous flavivirus infection(s) in hamsters, their antibody response, and subsequent challenge with YFV.
- Reduced YFV viremia and alteration of liver function in hamsters previously infected with heterologous flaviviruses.
- Histopathologic changes in hamsters challenged with YFV after previous infection with heterologous flaviviruses.
- In situ TUNEL analysis.
- DISCUSSION
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Monath T, 1989. Yellow fever. Monath T, ed. The Arboviruses: Epidemiology and Ecology. Boca Raton, FL: CRC Press, 139–231.
-
2
Monath T, 1997. Epidemiology of yellow fever: current status and speculations on future trends. Saluzzo J, Dodet B, eds. Factors in the Emergence of Arbovirus Diseases. Paris: Elsevier, 143–156.
-
3
Ashcroft MT, 1979. Historical evidence of resistance to yellow fever acquired by residence in India. Trans R Soc Trop Med Hyg 73 :247–248.
-
4
Theiler M, Anderson CR, 1975. The relative resistance of dengue-immune monkeys to yellow fever virus. Am J Trop Med Hyg 24 :115–117.
-
5
Monath TP, Craven RB, Adjukiewicz A, Germain M, Francy DB, Ferrara L, Samba EM, N’Jie H, Cham K, Fitzgerald SA, Crippen PH, Simpson DI, Bowen ET, Fabiyi A, Salaun JJ, 1980. Yellow fever in the Gambia, 1978–1979: epidemiologic aspects with observations on the occurrence of Orungo virus infections. Am J Trop Med Hyg 29 :912–928.
-
6
Henderson BE, Cheshire PP, Kirya GB, Lule M, 1970. Immunologic studies with yellow fever and selected African group B arboviruses in rhesus and vervet monkeys. Am J TropMed Hyg 19 :110–118.
-
7
Tesh RB, Guzman H, da Rosa AP, Vasconcelos PF, Dias LB, Bunnell JE, Zhang H, Xiao SY, 2001. Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus): I. virologic, biochemical and immunologic studies. J Infect Dis 183 :1431–1436.
-
8
Xiao SY, Zhang H, Guzman H, Tesh R, 2001. Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus): II. Pathology. J Infect Dis 183 :1437–1444.
-
9
Hotta S, 1969. Dengue and Related Hemorrhagic Diseases. St. Louis, MO: Warren H. Green.
-
10
Chen B, Wang I, 1974. Studies on attenuated Japanese B encephalitis virus vaccine. 1. Method for obtaining the attenuated 2-8 strain and its biological characteristics. Acta Microbiol Sinica 14 :176–184.
-
11
Xiao S-Y, Guzman H, Zhang H, Travassos da Rosa APA, Tesh RB, 2001. West Nile virus infection in the golden hamster (Mesocricetus auratus): a model of West Nile encephalitis. Emerg Infect Dis 7 :714–721.
-
12
Tesh R, Travassos da Rosa A, Guzman H, Araujo T, Xiao SY, 2002. Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis. Emerg Infect Dis 8 :245–251.
-
13
Reed LJ, Muench H, 1938. A simple method of estimating fifty per cent endpoints. Am J Hyg 27 :493–497.
-
14
Beaty BJ, Calisher C, Shope RE, 1995. Arboviruses. Lennette E, Lennette D, Lennette E, eds. Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections. Seventh edition. Washington, DC: American Public Health Association, 189–212.
-
15
Xiao S-Y, Zhang H, Yang Y, Tesh R, 2001. Pirital virus (Arenaviridae) infection in the Syrian golden hamster, Mesocricetus auratus: a new model for arenaviral hemorrhagic fever. Am J Trop Med Hyg 64 :111–118.
-
16
Kerr J, 1951. The clinical aspects and diagnosis of yellow fever. Strode G, ed. Yellow Fever. New York: McGraw-Hill, 385–425.
-
17
Elton N, Romero A, Trejos A, 1955. Clinical pathology of yellow fever. Am J Clin Pathol 25 :135–146.
-
18
Bugher J, 1951. The pathology of yellow fever. Strode G, ed. Yellow Fever. New York: McGraw-Hill, 137–163.
-
19
Hudson N, 1928. The pathology of experimental yellow fever in the Macacus rhesus. I. Gross pathology. Am J Pathol 4 :395–407.
-
20
Hudson N, 1928. The pathology of experimental yellow fever in the Macacus rhesus. II. Microscopic pathology. Am J Pathol 4 :407–418.
-
21
Hudson N, 1928. The pathology of experimental yellow fever in the Macacus rhesus. III. Comparison with the pathology of yellow fever in man. Am J Pathol 4 :419–439.
-
22
Bearcroft W, 1957. The histopathology of the liver of yellow fever-infected rhesus monkeys. J Pathol Bacteriol 74 :295–303.
-
23
Tigertt W, Berge T, Gochenour WS, Gleiser C, 1960. Experimental yellow fever. Trans NY Acad Sci 22 :323–333.
-
24
La Montaque J, 1983. Summary of a workshop on disease mechanisms and prospects for prevention of Reye’s syndrome. J Infect Dis 148 :943–950.
-
25
Craighead J, 2000. Pathology and Pathogenesis of Human Viral Disease. San Diego: Academic Press.
-
26
Fromenty B, Berson A, Pessayre D, 1997. Microvesicular steatosis an steatohepatitis: role of mitochondrial dysfunction and lipid peroxidation. J Hepatol 26 :13–22.
-
27
Rosser B, Gores GJ, 1995. Liver cell necrosis: cellular mechanisms and clinical implications. Gastroenterology 108 :252–275.
-
28
Lemasters J, Nieminen A, 1997. Mitochondrial oxygen radical formation during reductive and oxidative stress to intact hepatocytes. Biosci Rep 17 :281–291.
-
29
Lemasters J, 1999. Mechanisms of hepatic toxicity. V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis. Am J Physiol 276 :G1–G6.
-
30
Lerat H, Honda M, Beard MR, Loesch K, Sun J, Yang Y, Okuda M, Gosert R, Xiao SY, Weinman SA, Lemon SM, 2002. Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus. Gastroenterology 122 :352–365.
-
31
Okuda M, Li K, Beard MR, Showalter LA, Scholle F, Lemon SM, Weinman SA, 2002. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 122 :366–375.
-
32
Dennis LH, Reisberg BE, Crosbie J, Crozier D, Conrad ME, 1969. The original haemorrhagic fever: yellow fever. Br J Haematol 17 :455–462.
-
33
Halstead S, 1988. Pathogenesis of dengue: challenges to molecular biology. Science 239 :476–481.
-
34
Kliks S, Nisalak A, Brandt W, Wahl L, Burke D, 1989. Antibody dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever. Am J Trop Med Hyg 40 :444–451.
-
35
Roehrig J, 1997. Immunochemistry of dengue viruses. Gubler D, Kuno G, eds. Dengue and Dengue Hemorrhagic Fever. New York: CAB International, 199–219.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 21 | 21 | 8 |
| Full Text Views | 291 | 119 | 0 |
| PDF Downloads | 79 | 31 | 0 |