• 1

    Yoshida M, Seiki M, Yamagushi K, Takatsuki K, 1984. Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Natl Acad Sci USA 81 :2534–2537.

    • Search Google Scholar
    • Export Citation
  • 2

    Román GC, Osame M, 1988. Identity of HTLV-1 associated tropical spastic paraparesis and HTLV-1 associated myelopathy (letter). Lancet 1 :651.

    • Search Google Scholar
    • Export Citation
  • 3

    Hashiguchi T, Osame M, Arimura K, 1989. Skin manifestations in HTLV-1 associated myelopathy (HAM): xerosis and erythema. Róman CG, Vernant JC, Osame M, eds. HTLV-1 and the Nervous System. New York: Alan R. Liss, 443–448.

  • 4

    La Grenade L, Manns A, Fletcher V, Derm D, Carberry C, Hanchard B, Maloney EM, Cranston B, Williams NP, Wilks R, Kang EC, Blattner WA, 1998. Clinical, pathologic, and immunologic features of human T-lymphotropic virus type I-associated infective dermatites in children. Arch Dermatol 134 :439–444.

    • Search Google Scholar
    • Export Citation
  • 5

    Setoyama M, Mizoguchi S, Kanzaki T, 1998. Prurigo as a clinical prodrome to adult T-cell leukaemia/lymphoma. Br J Dermatol 138 :137–140.

    • Search Google Scholar
    • Export Citation
  • 6

    Laird PW, Zijderveld A, Linders K, Rudnicki A, Jaenisch R, Berns A, 1991. Simplified mammalian DNA isolation procedure. Nucleic Acids Res 19 :4293.

    • Search Google Scholar
    • Export Citation
  • 7

    Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB, Erlich HA, 1988. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 72 :1117–1123.

    • Search Google Scholar
    • Export Citation
  • 8

    Barros F, Carracedo A, Lareu MV, Rodriguez-Calvo MS, 1991. Electrophoretic human leukocyte antigen HLA DQA1 DNA typing after polymerase chain reaction amplification. Electrophoresis 12 :1041–1045.

    • Search Google Scholar
    • Export Citation
  • 9

    Proietti FA, Lima-Martins MV, Passos VM, Brener S, Carneiro-Proietti AB, 1994. HTLV-I/II seropositivity among eligible blood donors from Minas Gerais State, Brasil (letter). Vox Sang 67 :77.

    • Search Google Scholar
    • Export Citation
  • 10

    Murphy EL, Hanchard B, Figueroa JP, Gibbs WN, Lofters WS, Campbell M, Goedert JJ, Blattner WA, 1991. Human T-cell lymphotropic virus type 1 (HTLV-1) seroprevalence in Jamaica. Demographic determinants. Am J Epidemiol 133 :1114–1124.

    • Search Google Scholar
    • Export Citation
  • 11

    Hall WW, 1994. Human T cell lymphotropic virus type I and cutaneous T cell leukemia/lymphoma. J Exp Med 180 :1581–1585.

  • 12

    Katsuki T, Katsuki K, Imai J, Hinuma Y, 1987. Immunosuppression in healthy carriers of adult T-cell leukemia retrovirus (HTLV-1): impairment of T-cell control of Epstein-Barr virus infected B-cells. Jpn J Cancer Res 78 :639–642.

    • Search Google Scholar
    • Export Citation
  • 13

    Goncalves DU, Guedes AC, Carneiro-Proietti AB, Pinheiro SR, Catalan-Soares B, Proietti FA, Lambertucci JR, 1999. Simultaneous occurrence of HTLV-1 associated myelopathy, uveitis and smouldering adult T cell leukaemia. Int J STD AIDS 10 :336–337.

    • Search Google Scholar
    • Export Citation
  • 14

    Setoyama M, Kerdel FA, Elgart G, Kanzaki T, Byrnes JJ, 1998. Detection of HTLV-1 by polymerase chain reaction in situ hybridization in adult T-cell leukemia/lymphoma. Am J Pathol 152 :683–689.

    • Search Google Scholar
    • Export Citation
  • 15

    Yamaguchi K, Kiyokawa T, Nakada K, Yul LS, Asou N, Ishii T, Sanada I, Seiki M, Yoshida M, Matutes E, 1988. Polyclonal integration of HTLV-1 proviral DNA in lymphocytes from HTLV-1 seropositive individuals: an intermediate state between the healthy carrier state and smouldering ATLL. Br J Haematol 68 :169–174.

    • Search Google Scholar
    • Export Citation
  • 16

    Takemoto S, Matsuoka M, Yamaguchi K, Takatsuki K, 1994. A novel diagnostic method of adult T-cell leukemia: monoclonal integration of human T-cell lymphotropic virus type I provirus DNA detected by inverse polymerase chain reaction. Blood 84 :3080–3085.

    • Search Google Scholar
    • Export Citation
 
 
 

 

 
 
 

 

 

 

 

 

 

DERMATOLOGIC LESIONS IN ASYMPTOMATIC BLOOD DONORS SEROPOSITIVE FOR HUMAN T CELL LYMPHOTROPIC VIRUS TYPE-1

View More View Less
  • 1 Departments of Internal Medicine and Basic Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Minas Gerais State Center of Hematology and Hemotherapy, Belo Horizonte, Minas Gerais, Brazil

Dermatologic manifestations are quite common in patients with adult T cell leukemia/lymphoma and myelopathy/tropical spastic paraparesis associated with infection with human T cell lymphotropic virus type-1 (HTLV-1). In this study, we evaluated the dermatologic lesions of eligible blood donors in the state of Minas Gerais in Brazil who were seropositive but asymptomatic for infection with HTLV-1. The study population was composed of 128 HTLV-1-seropositive individuals and 108 seronegative controls. All individuals underwent a dermatologic evaluation. Biopsy specimens were obtained from abnormal and normal skin samples of seropositive individuals in an attempt to detect HTLV-1 in tissue samples by a polymerase chain reaction. Dermatologic alterations were observed more frequently in the seropositive group (adjusted odds ratio [OR] = 8.77, 95% confidence interval [CI] = 4.11–18.71). The most common skin diseases were dermatophytoses (adjusted OR = 3.32, 95% CI = 1.50–7.35), seborrheic dermatitis (OR = 3.53, 95% CI = 0.67–24.66), and acquired ichthyosis (P = 0.001). Virus was detected more frequently in abnormal skin samples. Dermatologic lesions probably related to HTLV-1 infection were diagnosed in eligible blood donors who were infected with this virus, who were previously considered to be asymptomatic carriers of HTLV-1.

Save