A retrospective examination was made of archival data on 98 patient episodes of infection with Plasmodium vivax occurring over a period of 4–11 weeks to document changes in hemoglobin (Hb) concentrations associated with continuing parasitemia. The mean percentage change in the Hb concentration for each of the 10 seven-day intervals was −13.4, −10.9, −4.8, 0.12, 0.94, 4.0, 0.69, 11.6, 2.4, and 8.3, respectively. An equilibrium appeared to be established between weeks 4 and 6. Decreases in Hb concentrations were greatest following the first week of parasitemia. Total restoration to preinfection levels did not occur during persistent parasitemia.
Copyright 2003 The American Society of Tropical Medicine 2003