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RefWorks
Reference Manager
BibTeX
Zotero
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-
1
WHO, 1987. World malaria situation 1985. World Health Stat Q 40 :142–170.
-
2
WHO, 1997. Malaria in the South-East Asia Region. New Delhi: Regional Office for South-East Asia, World Health Organization.
-
3
Meuwissen TJHE, 1964. The use of medicated salt in an antimalaria campaign in West New Guinea. Trop Geogr Med 16 :245–255.
-
4
Clyde DF, McCarthy VC, Miller RM, Hornick RB, 1976. Chloroquine-resistant falciparum malaria from Irian Jaya, Indonesian New Guinea. Am J Trop Med Hyg 79 :38–41.
-
5
Ebisawa I, Fukuyama T, 1975. Chloroquine resistance of Plasmodium falciparum in West Irian and East Kalimantan. Ann Trop Med Parasitol 69 :275–282.
-
6
Hoffman SL, Campbell J, Rustama D, Dimpudus AJ, Surumpaet B, 1987. Pyrimethamine-sulfadoxine still effective against Plasmodium falciparum in Jayapura, Irian Jaya: RI-type resistance in 2 of 18 patients. Trans R Soc Trop Med Hyg 81 :276–277.
-
7
Hoffman SL, Harun S, Campbell JR, Purnomo, Marwoto HA, Dimpudus AJ, Rustama D, Oetoma HS, Rai NK, Laughlin LW, 1984. Prolonged incubation improves the micro-scale in-vitro test for drug sensitivity of Plasmodium falciparum.Lancet 1 :7–9.
-
8
Baird JK, Basri H, Purnomo, Bangs MJ, Subianto B, Patchen LC, Hoffman SL, 1991. Resistance to chloroquine by Plasmodium vivax in Irian Jaya, Indonesia. Am J Trop Med Hyg 44 :547–552.
-
9
Baird JK, Wiady I, Fryauff DJ, Sutanihardja MA, Leksana B, Widjaya H, Kysdarmanto, Subianto B, 1997. In vivo resistance to chloroquine by Plasmodium vivax and Plasmodium falciparum at Nabire, Irian Jaya, Indonesia. Am J Trop Med Hyg 56 :627–631.
-
10
Fryauff DJ, Sumawinata I, Purnomo, Richie TL, Tjitra E, Bangs MJ, Kadir A, Ingkokusumo G, 1999. In vivo responses to antimalarials by Plasmodium falciparum and Plasmodium vivax from isolated Gag Island off northwest Irian Jaya, Indonesia. Am J Trop Med Hyg 60 :542–546.
-
11
Gomez-Saladin E, Fryauff DJ, Taylor WR, Laksana BS, Susanti AI, Purnomo, Subianto B, Richie TL, 1999. Plasmodium falciparum mdr1 mutations and in vivo chloroquine resistance in Indonesia. Am J Trop Med Hyg 61 :240–244.
-
12
Pribadi W, Sutanto I, Atmosoedjono S, Rasidi R, Surya LK, Susanto L, 1998. Malaria situation in several villages around Timika, south central Irian Jaya, Indonesia. Southeast Asian J Trop Med Public Health 29 :228–235.
-
13
Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LM, Sidhu AB, Naude B, Deitsch KW, Su XZ, Wootton JC, Roepe PD, Wellems TE, 2000. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell 6 :861–871.
-
14
Nagesha HS, Din-Syafruddin, Casey GJ, Susanti AI, Fryauff DJ, Reeder JC, Cowman AF, 2001. Mutations in the pfmdr1, dhfr and dhps genes of Plasmodium falciparum are associated with in vivo drug resistance in Irian Jaya, Indonesia. Trans R Soc Trop Med and Hyg 95 :43–49.
-
15
Dawson-Saunders B, Trapp RG, 1994. Basic and Clinical Biostatistics. Norwalk, CT: Appleton and Lange.
-
16
Mehlotra RK, Fujioka H, Roepe PD, Janneh O, Ursos LM, Jacobs-Lorena V, McNamara DT, Bockarie MJ, Kazura JW, Kyle DE, Fidock DA, Zimmerman PA, 2001. Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America. Proc Natl Acad Sci USA 98 :12689–12694.
-
17
Krogstad DJ, Gluzman IY, Kyle DE, Oduola AM, Martin SK, 1987. Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance. Science 238 :1283–1285.
-
18
Foote SJ, Kyle DE, Martin RK, Oduola AMJ, Forsyth K, Kemp DJ, Cowman AF, 1990. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum.Nature 345 :255–258.
-
19
Reed MB, Saliba KS, Caruana SR, Kirk K, Cowman AF, 2000. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum.Nature 403 :906–909.
-
20
Basco LK, Ringwald P, 2001. Analysis of the key pfcrt point mutation and in vitro and in vivo response to chloroquine in Yaounde, Cameroon. J Infect Dis 183 :1828–1831.
-
21
Cooper RA, Ferdig MT, Su XZ, Ursos LM, Mu J, Nomura T, Fujioka H, Fidock DA, Roepe PD, Wellems TE, 2002. Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.Mol Pharmacol 61 :35–42.
-
22
Djimde A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Diourte Y, Dicko A, Su XZ, Nomura T, Fidock DA, Wellems TE, Plowe CV, Coulibaly D, 2001. A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med 344 :257–263.
-
23
Kyosiimire-Lugemwa J, Nalunkuma-Kazibwe AJ, Mujuzi G, Mulindwa H, Talisuna A, Egwang TG, 2002. The Lys-76-Thr mutation in PfCRT and chloroquine resistance in Plasmodium falciparum isolates from Uganda. Trans R Soc Trop Med Hyg 96 :91–95.
-
24
Mayor AG, Gomez-Olive X, Aponte JJ, Casimiro S, Mabunda S, Dgedge M, Barreto A, Alonso PL, 2001. Prevalence of the K76T mutation in the putative Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene and its relation to chloroquine resistance in Mozambique. J Infect Dis 183 :1413–1416.
-
25
Pillai DR, Labbe AC, Vanisaveth V, Hongvangthong B, Pomphida S, Inkathone S, Zhong K, Kain KC, 2001. Plasmodium falciparum malaria in Laos: chloroquine treatment outcome and predictive value of molecular markers. J Infect Dis 183 :789–795.
-
26
Su X-Z, Kirkman LA, Fujioka H, Wellems TE, 1997. Complex polymorphisms in an ~330 kDa protein are linked to chloroquine-resistant P falciparum in Southeast Asia and Africa. Cell 91 :593–603.
-
27
Vieira PP, das Gracas Alecrim M, da Silva LH, Gonzalez-Jimenez I, Zalis MG. 2001. Analysis of the PfCRT K76T mutation in Plasmodium falciparum isolates from the Amazon region of Brazil. J Infect Dis 183 :1832–1833.
-
28
Wootton JC, Feng X, Ferdig MT, Cooper RA, Mu J, Baruch DI, Magill AJ, Su X-Z, 2002. Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum.Nature 418 :320–323.
-
29
Babiker HA, Pringle SJ, Abdel-Muhsin A, Mackinnon M, Hunt P, Walliker D, 2001. High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance gene pfmdr1.J Infect Dis 183 :1535–1538.
-
30
Maguire JD, Susanti AI, Krisin, Sismadi P, Fryauff DJ, Baird JK, 2001. The T76 mutation in the pfcrt gene of Plasmodium falciparum and clinical chloroquine resistance phenotypes in Papua, Indonesia. Ann Trop Med Parasitol 95 :559–572.
-
31
Rieckmann KH, Campbell GH, Sax LJ, Mrema JE, 1978. Drug sensitivity of Plasmodium falciparum: an in vitro microtechnique. Lancet 1 :22–23.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1865 | 1791 | 23 |
| Full Text Views | 286 | 14 | 0 |
| PDF Downloads | 64 | 11 | 0 |
NEW HAPLOTYPES OF THE PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER (PFCRT) GENE AMONG CHLOROQUINE-RESISTANT PARASITE ISOLATES
HADYA S. NAGESHA
HADYA S. NAGESHA
The Walter and Eliza Hall Institute for Medical Research, Melbourne, Australia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; United States Naval Medical Research Unit No. 2, U.S. Embassy, Jakarta, Indonesia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Australian Army Malaria Institute, Brisbane, Australia
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GERARD J. CASEY
GERARD J. CASEY
The Walter and Eliza Hall Institute for Medical Research, Melbourne, Australia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; United States Naval Medical Research Unit No. 2, U.S. Embassy, Jakarta, Indonesia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Australian Army Malaria Institute, Brisbane, Australia
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KARL H. RIECKMANN
KARL H. RIECKMANN
The Walter and Eliza Hall Institute for Medical Research, Melbourne, Australia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; United States Naval Medical Research Unit No. 2, U.S. Embassy, Jakarta, Indonesia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Australian Army Malaria Institute, Brisbane, Australia
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DAVID J. FRYAUFF
DAVID J. FRYAUFF
The Walter and Eliza Hall Institute for Medical Research, Melbourne, Australia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; United States Naval Medical Research Unit No. 2, U.S. Embassy, Jakarta, Indonesia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Australian Army Malaria Institute, Brisbane, Australia
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BUDI S. LAKSANA
BUDI S. LAKSANA
The Walter and Eliza Hall Institute for Medical Research, Melbourne, Australia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; United States Naval Medical Research Unit No. 2, U.S. Embassy, Jakarta, Indonesia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Australian Army Malaria Institute, Brisbane, Australia
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JOHN C. REEDER
JOHN C. REEDER
The Walter and Eliza Hall Institute for Medical Research, Melbourne, Australia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; United States Naval Medical Research Unit No. 2, U.S. Embassy, Jakarta, Indonesia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Australian Army Malaria Institute, Brisbane, Australia
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JASON D. MAGUIRE
JASON D. MAGUIRE
The Walter and Eliza Hall Institute for Medical Research, Melbourne, Australia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; United States Naval Medical Research Unit No. 2, U.S. Embassy, Jakarta, Indonesia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Australian Army Malaria Institute, Brisbane, Australia
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J. KEVIN BAIRD
J. KEVIN BAIRD
The Walter and Eliza Hall Institute for Medical Research, Melbourne, Australia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; United States Naval Medical Research Unit No. 2, U.S. Embassy, Jakarta, Indonesia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Australian Army Malaria Institute, Brisbane, Australia
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Mutations in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene were examined to assess their associations with chloroquine resistance in clinical samples from Armopa (Papua) and Papua New Guinea. In Papua, two of the five pfcrt haplotypes found were new: SVIET from Armopa and CVIKT from an isolate in Timika. There was also a strong association (P < 0.0001) between the pfcrt 76T allele and chloroquine resistance in 50 samples. In Papua New Guinea, mutations in the pfcrt gene were observed in 15 isolates with chloroquine minimum inhibitory concentrations (MICs) of 16–64 pmol, while the remaining six isolates, which had a wild-type pfcrt gene at codon 76, had MICs of 2–8 pmol. These observations confirm that mutations at codon 76 in the pfcrt gene are present in both in vivo and in vitro cases of chloroquine resistance, and that detection of the pfcrt 76T allele could predict potential chloroquine treatment failures.
Author Notes
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-
1
WHO, 1987. World malaria situation 1985. World Health Stat Q 40 :142–170.
-
2
WHO, 1997. Malaria in the South-East Asia Region. New Delhi: Regional Office for South-East Asia, World Health Organization.
-
3
Meuwissen TJHE, 1964. The use of medicated salt in an antimalaria campaign in West New Guinea. Trop Geogr Med 16 :245–255.
-
4
Clyde DF, McCarthy VC, Miller RM, Hornick RB, 1976. Chloroquine-resistant falciparum malaria from Irian Jaya, Indonesian New Guinea. Am J Trop Med Hyg 79 :38–41.
-
5
Ebisawa I, Fukuyama T, 1975. Chloroquine resistance of Plasmodium falciparum in West Irian and East Kalimantan. Ann Trop Med Parasitol 69 :275–282.
-
6
Hoffman SL, Campbell J, Rustama D, Dimpudus AJ, Surumpaet B, 1987. Pyrimethamine-sulfadoxine still effective against Plasmodium falciparum in Jayapura, Irian Jaya: RI-type resistance in 2 of 18 patients. Trans R Soc Trop Med Hyg 81 :276–277.
-
7
Hoffman SL, Harun S, Campbell JR, Purnomo, Marwoto HA, Dimpudus AJ, Rustama D, Oetoma HS, Rai NK, Laughlin LW, 1984. Prolonged incubation improves the micro-scale in-vitro test for drug sensitivity of Plasmodium falciparum.Lancet 1 :7–9.
-
8
Baird JK, Basri H, Purnomo, Bangs MJ, Subianto B, Patchen LC, Hoffman SL, 1991. Resistance to chloroquine by Plasmodium vivax in Irian Jaya, Indonesia. Am J Trop Med Hyg 44 :547–552.
-
9
Baird JK, Wiady I, Fryauff DJ, Sutanihardja MA, Leksana B, Widjaya H, Kysdarmanto, Subianto B, 1997. In vivo resistance to chloroquine by Plasmodium vivax and Plasmodium falciparum at Nabire, Irian Jaya, Indonesia. Am J Trop Med Hyg 56 :627–631.
-
10
Fryauff DJ, Sumawinata I, Purnomo, Richie TL, Tjitra E, Bangs MJ, Kadir A, Ingkokusumo G, 1999. In vivo responses to antimalarials by Plasmodium falciparum and Plasmodium vivax from isolated Gag Island off northwest Irian Jaya, Indonesia. Am J Trop Med Hyg 60 :542–546.
-
11
Gomez-Saladin E, Fryauff DJ, Taylor WR, Laksana BS, Susanti AI, Purnomo, Subianto B, Richie TL, 1999. Plasmodium falciparum mdr1 mutations and in vivo chloroquine resistance in Indonesia. Am J Trop Med Hyg 61 :240–244.
-
12
Pribadi W, Sutanto I, Atmosoedjono S, Rasidi R, Surya LK, Susanto L, 1998. Malaria situation in several villages around Timika, south central Irian Jaya, Indonesia. Southeast Asian J Trop Med Public Health 29 :228–235.
-
13
Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LM, Sidhu AB, Naude B, Deitsch KW, Su XZ, Wootton JC, Roepe PD, Wellems TE, 2000. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell 6 :861–871.
-
14
Nagesha HS, Din-Syafruddin, Casey GJ, Susanti AI, Fryauff DJ, Reeder JC, Cowman AF, 2001. Mutations in the pfmdr1, dhfr and dhps genes of Plasmodium falciparum are associated with in vivo drug resistance in Irian Jaya, Indonesia. Trans R Soc Trop Med and Hyg 95 :43–49.
-
15
Dawson-Saunders B, Trapp RG, 1994. Basic and Clinical Biostatistics. Norwalk, CT: Appleton and Lange.
-
16
Mehlotra RK, Fujioka H, Roepe PD, Janneh O, Ursos LM, Jacobs-Lorena V, McNamara DT, Bockarie MJ, Kazura JW, Kyle DE, Fidock DA, Zimmerman PA, 2001. Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America. Proc Natl Acad Sci USA 98 :12689–12694.
-
17
Krogstad DJ, Gluzman IY, Kyle DE, Oduola AM, Martin SK, 1987. Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance. Science 238 :1283–1285.
-
18
Foote SJ, Kyle DE, Martin RK, Oduola AMJ, Forsyth K, Kemp DJ, Cowman AF, 1990. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum.Nature 345 :255–258.
-
19
Reed MB, Saliba KS, Caruana SR, Kirk K, Cowman AF, 2000. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum.Nature 403 :906–909.
-
20
Basco LK, Ringwald P, 2001. Analysis of the key pfcrt point mutation and in vitro and in vivo response to chloroquine in Yaounde, Cameroon. J Infect Dis 183 :1828–1831.
-
21
Cooper RA, Ferdig MT, Su XZ, Ursos LM, Mu J, Nomura T, Fujioka H, Fidock DA, Roepe PD, Wellems TE, 2002. Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.Mol Pharmacol 61 :35–42.
-
22
Djimde A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Diourte Y, Dicko A, Su XZ, Nomura T, Fidock DA, Wellems TE, Plowe CV, Coulibaly D, 2001. A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med 344 :257–263.
-
23
Kyosiimire-Lugemwa J, Nalunkuma-Kazibwe AJ, Mujuzi G, Mulindwa H, Talisuna A, Egwang TG, 2002. The Lys-76-Thr mutation in PfCRT and chloroquine resistance in Plasmodium falciparum isolates from Uganda. Trans R Soc Trop Med Hyg 96 :91–95.
-
24
Mayor AG, Gomez-Olive X, Aponte JJ, Casimiro S, Mabunda S, Dgedge M, Barreto A, Alonso PL, 2001. Prevalence of the K76T mutation in the putative Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene and its relation to chloroquine resistance in Mozambique. J Infect Dis 183 :1413–1416.
-
25
Pillai DR, Labbe AC, Vanisaveth V, Hongvangthong B, Pomphida S, Inkathone S, Zhong K, Kain KC, 2001. Plasmodium falciparum malaria in Laos: chloroquine treatment outcome and predictive value of molecular markers. J Infect Dis 183 :789–795.
-
26
Su X-Z, Kirkman LA, Fujioka H, Wellems TE, 1997. Complex polymorphisms in an ~330 kDa protein are linked to chloroquine-resistant P falciparum in Southeast Asia and Africa. Cell 91 :593–603.
-
27
Vieira PP, das Gracas Alecrim M, da Silva LH, Gonzalez-Jimenez I, Zalis MG. 2001. Analysis of the PfCRT K76T mutation in Plasmodium falciparum isolates from the Amazon region of Brazil. J Infect Dis 183 :1832–1833.
-
28
Wootton JC, Feng X, Ferdig MT, Cooper RA, Mu J, Baruch DI, Magill AJ, Su X-Z, 2002. Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum.Nature 418 :320–323.
-
29
Babiker HA, Pringle SJ, Abdel-Muhsin A, Mackinnon M, Hunt P, Walliker D, 2001. High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance gene pfmdr1.J Infect Dis 183 :1535–1538.
-
30
Maguire JD, Susanti AI, Krisin, Sismadi P, Fryauff DJ, Baird JK, 2001. The T76 mutation in the pfcrt gene of Plasmodium falciparum and clinical chloroquine resistance phenotypes in Papua, Indonesia. Ann Trop Med Parasitol 95 :559–572.
-
31
Rieckmann KH, Campbell GH, Sax LJ, Mrema JE, 1978. Drug sensitivity of Plasmodium falciparum: an in vitro microtechnique. Lancet 1 :22–23.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1865 | 1791 | 23 |
| Full Text Views | 286 | 14 | 0 |
| PDF Downloads | 64 | 11 | 0 |