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-
1
Rossignol JF, Cavier R, 1975. New derivative of 2-benzamido-5-nitrothiols. Chem Abs 83 :28216.
-
2
Rossignol JF, Maisonneuve H, 1984. Nitazoxanide in the treatment of Taenia saginata and Hymenolepis nana infections. Am J Trop Med Hyg 33 :511–512.
-
3
Rossignol JF, Abaza H, Friedman H, 1998. Successful treatment of fasciolosis with nitazoxanide. Trans R Soc Trop Med Hyg 92 :103–104.
-
4
Doumbo O, Rossignol JF, Pichard E, Traore HA, Dembele M, Diakite M, Traore F, Diallo DA, 1997. Nitazoxanide in the treatment of cryptosporidial diarrhea and other intestinal parasitic infections associated with acquired immunodeficiency syndrome in tropical Africa. Am J Trop Med Hyg 56 :637–639.
-
5
Romero CR, Robert GL, Muñoz GMR, Geyne CA, 1997. Nitazoxanide for the treatment of intestinal protozoan and helminthic infections in Mexico. Trans R Soc Trop Med Hyg 91 :701–703.
-
6
Abaza H, El-Zayali A, Kabil SM, Rizk H, 1998. Nitazoxanide in the treatment of patients with intestinal protozoan and helminthic infections: a report on 546 patients in Egypt. Curr Ther Res 59 :116–121.
-
7
Garcia L, Bullock-Iacullo S, Fritsche T, Healy G, McAuley J, Neimeister R, Palmer J, Wilson M, Wong J, 1997. Procedures for Recovery and Identification of Parasites from the Intestinal Tract. Approved Guideline. Wayne, PA: National Committee for Clinical and Laboratory Standards, 17: 8–10 and 25–27.
-
8
Biagi F, Portilla J, 1957. Comparison of methods of examining stools for parasites. Am J Trop Med Hyg 6 :906–911.
-
9
Henriksen SA, Pohlenz JFL, 1981. Staining cryptosporidia by a modified Ziehl-Nielsen technique. Acta Vet Scand 22 :594–596.
-
10
Ortiz J, Ayoub A, Gargala G, Chegne N, Favennec L, 2001. Randomized clinical study of nitazoxanide compared to metronidazole in the treatment of symptomatic giardiasis in children from northern Peru. Aliment Pharmacol Ther 15 :1409–1415.
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EPIDEMIOLOGY AND CONTROL OF INTESTINAL PARASITES WITH NITAZOXANIDE IN CHILDREN IN MEXICO
ELVIA DIAZ
ELVIA DIAZ
Unidad de Medicina Familiar 91, Instituto Mexicano del Seguro Social, Estado de Mexico, México; Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Estado de México, México; Laboratorio de Parasitología y Micología, Hospital Infantil de México Federico Gómez, Secretaría de Salubridad y Asistencia, México, DF, México
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JAIME MONDRAGON
JAIME MONDRAGON
Unidad de Medicina Familiar 91, Instituto Mexicano del Seguro Social, Estado de Mexico, México; Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Estado de México, México; Laboratorio de Parasitología y Micología, Hospital Infantil de México Federico Gómez, Secretaría de Salubridad y Asistencia, México, DF, México
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ENRIQUE RAMIREZ
ENRIQUE RAMIREZ
Unidad de Medicina Familiar 91, Instituto Mexicano del Seguro Social, Estado de Mexico, México; Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Estado de México, México; Laboratorio de Parasitología y Micología, Hospital Infantil de México Federico Gómez, Secretaría de Salubridad y Asistencia, México, DF, México
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ROSAMARIA BERNAL
ROSAMARIA BERNAL
Unidad de Medicina Familiar 91, Instituto Mexicano del Seguro Social, Estado de Mexico, México; Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Estado de México, México; Laboratorio de Parasitología y Micología, Hospital Infantil de México Federico Gómez, Secretaría de Salubridad y Asistencia, México, DF, México
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The purpose of this study was to evaluate the efficacy and the tolerance of nitazoxanide in children as a single broad-spectrum antiparasitic agent in the treatment of mixed parasite infections with both intestinal protozoa and helminths. Two hundred seventy-two children (age range = 2–14 years) participated in this study. We systematically surveyed every household head using questionnaires designed to obtain information about household socioeconomic status and hygiene. Parasitic infections were confirmed by three stool examinations using direct smear, Ferreira concentration, and cold acid-fast Kinyoun staining methods. One hundred twenty-one (44%) children tested positive for protozoa such as Giardia lamblia (18%), Entamoeba histolytica/E. dispar (10%), Blastocystis hominis (7%), Cryptosporidium parvum (4%), and Cyclospora cayetanensis (3%), and helminths such as Hymenolepis nana (10%), Trichuris trichiura (6%), and Ascaris lumbricoides (6%). There were also two cases of infection with Enterobius vermicularis. After a complete physical examination was performed, 121 patients received treatment with nitazoxanide. Overall, 84% of the protozoa and 95% of the helminths were completely eliminated from the patients. Nitazoxanide was very well tolerated, with no serious adverse effects reported.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Rossignol JF, Cavier R, 1975. New derivative of 2-benzamido-5-nitrothiols. Chem Abs 83 :28216.
-
2
Rossignol JF, Maisonneuve H, 1984. Nitazoxanide in the treatment of Taenia saginata and Hymenolepis nana infections. Am J Trop Med Hyg 33 :511–512.
-
3
Rossignol JF, Abaza H, Friedman H, 1998. Successful treatment of fasciolosis with nitazoxanide. Trans R Soc Trop Med Hyg 92 :103–104.
-
4
Doumbo O, Rossignol JF, Pichard E, Traore HA, Dembele M, Diakite M, Traore F, Diallo DA, 1997. Nitazoxanide in the treatment of cryptosporidial diarrhea and other intestinal parasitic infections associated with acquired immunodeficiency syndrome in tropical Africa. Am J Trop Med Hyg 56 :637–639.
-
5
Romero CR, Robert GL, Muñoz GMR, Geyne CA, 1997. Nitazoxanide for the treatment of intestinal protozoan and helminthic infections in Mexico. Trans R Soc Trop Med Hyg 91 :701–703.
-
6
Abaza H, El-Zayali A, Kabil SM, Rizk H, 1998. Nitazoxanide in the treatment of patients with intestinal protozoan and helminthic infections: a report on 546 patients in Egypt. Curr Ther Res 59 :116–121.
-
7
Garcia L, Bullock-Iacullo S, Fritsche T, Healy G, McAuley J, Neimeister R, Palmer J, Wilson M, Wong J, 1997. Procedures for Recovery and Identification of Parasites from the Intestinal Tract. Approved Guideline. Wayne, PA: National Committee for Clinical and Laboratory Standards, 17: 8–10 and 25–27.
-
8
Biagi F, Portilla J, 1957. Comparison of methods of examining stools for parasites. Am J Trop Med Hyg 6 :906–911.
-
9
Henriksen SA, Pohlenz JFL, 1981. Staining cryptosporidia by a modified Ziehl-Nielsen technique. Acta Vet Scand 22 :594–596.
-
10
Ortiz J, Ayoub A, Gargala G, Chegne N, Favennec L, 2001. Randomized clinical study of nitazoxanide compared to metronidazole in the treatment of symptomatic giardiasis in children from northern Peru. Aliment Pharmacol Ther 15 :1409–1415.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 579 | 421 | 21 |
| Full Text Views | 654 | 8 | 0 |
| PDF Downloads | 247 | 11 | 0 |