NITAZOXANIDE: AN IMPORTANT ADVANCE IN ANTI-PARASITIC THERAPY

A. CLINTON WHITE JR. Infectious Diseases Section, Department of Medicine, Baylor College of Medicine, Houston, Texas

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  • 1

    White AC Jr, 2000. The disappearing arsenal of antiparasitic drugs. N Engl J Med 343 :1273–1274.

  • 2

    Wickware P, 2002. Resurrecting the resurrection drug. Nat Med 8 :908–909.

  • 3

    Rossignol JF, Maisonneuve H, 1984. Nitazoxanide in the treatment of Taenia saginata and Hymenolepis nana infections. Am J Trop Med Hyg 33 :511–512.

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  • 4

    Rossignol JF, Ayoub A, Ayers MS, 2001. Treatment of diarrhea caused by Cryptosporidium parvum: a prospective randomized, double-blind, placebo-controlled study of nitazoxanide. J Infect Dis 184 :103–106.

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  • 5

    Amadi B, Mwiya M, Musuku J, Watuka A, Sianongo S, Ayoub A, Kelly P, 2002. Effect of nitazoxanide on morbidity and mortality in Zambian children with cryptosporidiosis: a randomised controlled trial. Lancet 360 :1375–1380.

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  • 6

    Rossignol JF, Hidalgo H, Feregrino M, Higuera F, Gomez WH, Romero JL, Padierna J, Geyne A, Ayers MS, 1998. A double-‘blind’ placebo-controlled study of nitazoxanide in the treatment of cryptosporidial diarrhoea in AIDS patients in Mexico. Trans R Soc Trop Med Hyg 92 :663–666.

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  • 7

    Ortiz JJ, Ayoub A, Gargala G, Chegne NL, Favennec L, 2001. Randomized clinical study of nitazoxanide compared to metronidazole in the treatment of symptomatic giardiasis in children from northern Peru. Aliment Pharmacol Ther 15 :1409–1415.

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  • 8

    Abboud P, Lemee V, Gargala G, Brasseur P, Ballet JJ, Borsa-Lebas F, Caron F, Favennec L, 2001. Successful treatment of metronidazole- and albendazole-resistant giardiasis with nitazoxanide in a patient with acquired immunodeficiency syndrome. Clin Infect Dis 32 :1792–1794.

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  • 9

    Gilles HM, Hoffman PS, 2002. Treatment of intestinal parasitic infections: a review of nitazoxanide. Trends Parasitol 18 :95–97.

  • 10

    Diaz E, Mondragon J, Ramirez E, Bernal R, 2003. Short report: epidemiology and control of intestinal parasites with nitazoxanide in children in Mexico. Am J Trop Med Hyg 68 :384–385.

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  • 11

    Favennec L, Jave Ortiz J, Gargala G, Lopez Chegne N, Ayoub A, Rossignol JF, 2003. Double-blind, randomized, placebo-controlled study of nitazoxanide in the treatment of fascioliasis in adults and children from northern Peru. Aliment Pharmacol Ther 17 :265–270.

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