SHORT REPORT: ANALYSIS OF ANTI-MALARIA IMMUNE RESPONSE DURING HUMAN IMMUNODEFICIENCY VIRUS INFECTION IN ADULTS IN KINSHASA, DEMOCRATIC REPUBLIC OF THE CONGO

M. KASHAMUKA Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Merck & Co., Inc., Blue Bell, Project SIDA, PNLS/NRL/Hopital General de Kinshasa, Democratic Republic of the Congo

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N. NZILA Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Merck & Co., Inc., Blue Bell, Project SIDA, PNLS/NRL/Hopital General de Kinshasa, Democratic Republic of the Congo

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L. MUSSEY Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Merck & Co., Inc., Blue Bell, Project SIDA, PNLS/NRL/Hopital General de Kinshasa, Democratic Republic of the Congo

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N. LUBAKI Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Merck & Co., Inc., Blue Bell, Project SIDA, PNLS/NRL/Hopital General de Kinshasa, Democratic Republic of the Congo

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T. C. QUINN Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Merck & Co., Inc., Blue Bell, Project SIDA, PNLS/NRL/Hopital General de Kinshasa, Democratic Republic of the Congo

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R. BOLLINGER Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Merck & Co., Inc., Blue Bell, Project SIDA, PNLS/NRL/Hopital General de Kinshasa, Democratic Republic of the Congo

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N. KUMAR Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Merck & Co., Inc., Blue Bell, Project SIDA, PNLS/NRL/Hopital General de Kinshasa, Democratic Republic of the Congo

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DOI:
https://doi.org/10.4269/ajtmh.2003.68.376
Volume/Issue:
Volume 68: Issue 3
Page(s):
376–378
Restricted access
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Co-infection of human immunodeficiency virus and malaria is not uncommon in people living in sub-Saharan Africa. Since HIV infection results in immune deficiency, it may alter the ability of HIV patients to mount proper immune responses against malaria parasites. We measured specific malaria antibodies in 47 specimens from 25 couples from Kinshasa, Democratic Republic of the Congo (DRC), according to their HIV status, and investigated probable interaction between malaria and HIV infection. Plasma samples were analyzed for HIV markers (western blot and viral load) and malaria parasite-specific antibody (antibody titer, pattern of antigen recognized by western blotting, and parasite neutralizing antibodies assayed by growth inhibition). No correlation was identified between measured HIV infection status and malaria-specific parameters.

Author Notes

Reprint requests: Dr. Nirbhay Kumar, E5144, MMI, BSPH, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, Telephone: 410-955-7177, Fax: 410-955-0105, E-mail: nkumar@jhsph.edu
Copyright:
Copyright 2003 The American Society of Tropical Medicine 2003
Received:
27 Aug 2002
|
Accepted:
30 Oct 2002
|
Published Online:
Mar 2003
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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