SEROTYPE-SPECIFIC DENGUE VIRUS CIRCULATION AND DENGUE DISEASE IN BANGKOK, THAILAND FROM 1973 TO 1999

ANANDA NISALAK Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Queen Sirikit National Institute of Child Health, Bangkok, Thailand; Department of Pediatrics, Chulalongkorn Hospital, Bangkok, Thailand; Department of International Health, Center for Immunization Research, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD; U.S. GlaxoSmithKline, Collegeville, PA; Department of Virus Diseases, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD

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TIMOTHY P. ENDY Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Queen Sirikit National Institute of Child Health, Bangkok, Thailand; Department of Pediatrics, Chulalongkorn Hospital, Bangkok, Thailand; Department of International Health, Center for Immunization Research, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD; U.S. GlaxoSmithKline, Collegeville, PA; Department of Virus Diseases, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD

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SUCHITRA NIMMANNITYA Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Queen Sirikit National Institute of Child Health, Bangkok, Thailand; Department of Pediatrics, Chulalongkorn Hospital, Bangkok, Thailand; Department of International Health, Center for Immunization Research, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD; U.S. GlaxoSmithKline, Collegeville, PA; Department of Virus Diseases, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD

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SIRIPEN KALAYANAROOJ Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Queen Sirikit National Institute of Child Health, Bangkok, Thailand; Department of Pediatrics, Chulalongkorn Hospital, Bangkok, Thailand; Department of International Health, Center for Immunization Research, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD; U.S. GlaxoSmithKline, Collegeville, PA; Department of Virus Diseases, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD

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USA THISAYAKORN Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Queen Sirikit National Institute of Child Health, Bangkok, Thailand; Department of Pediatrics, Chulalongkorn Hospital, Bangkok, Thailand; Department of International Health, Center for Immunization Research, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD; U.S. GlaxoSmithKline, Collegeville, PA; Department of Virus Diseases, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD

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ROBERT M. SCOTT Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Queen Sirikit National Institute of Child Health, Bangkok, Thailand; Department of Pediatrics, Chulalongkorn Hospital, Bangkok, Thailand; Department of International Health, Center for Immunization Research, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD; U.S. GlaxoSmithKline, Collegeville, PA; Department of Virus Diseases, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD

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DONALD S. BURKE Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Queen Sirikit National Institute of Child Health, Bangkok, Thailand; Department of Pediatrics, Chulalongkorn Hospital, Bangkok, Thailand; Department of International Health, Center for Immunization Research, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD; U.S. GlaxoSmithKline, Collegeville, PA; Department of Virus Diseases, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD

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CHARLES H. HOKE Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Queen Sirikit National Institute of Child Health, Bangkok, Thailand; Department of Pediatrics, Chulalongkorn Hospital, Bangkok, Thailand; Department of International Health, Center for Immunization Research, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD; U.S. GlaxoSmithKline, Collegeville, PA; Department of Virus Diseases, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD

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BRUCE L. INNIS Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Queen Sirikit National Institute of Child Health, Bangkok, Thailand; Department of Pediatrics, Chulalongkorn Hospital, Bangkok, Thailand; Department of International Health, Center for Immunization Research, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD; U.S. GlaxoSmithKline, Collegeville, PA; Department of Virus Diseases, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD

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DAVID W. VAUGHN Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Queen Sirikit National Institute of Child Health, Bangkok, Thailand; Department of Pediatrics, Chulalongkorn Hospital, Bangkok, Thailand; Department of International Health, Center for Immunization Research, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD; U.S. GlaxoSmithKline, Collegeville, PA; Department of Virus Diseases, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD

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DOI:
https://doi.org/10.4269/ajtmh.2003.68.191
Volume/Issue:
Volume 68: Issue 2
Page(s):
191–202
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Dengue virus circulation and association with epidemics and severe dengue disease were studied in hospitalized children with suspected dengue at the Queen Sirikit National Institute of Child Health in Bangkok, Thailand, from 1973 to 1999. Dengue serology was performed on all patients and viral isolation attempted on laboratory-confirmed patients. Acute dengue was diagnosed in 15,569 children and virus isolated from 4,846. DEN-3 was the most frequent serotype in primary dengue (49% of all isolates), DEN-2 in secondary and in dengue hemorrhagic fever (37% and 35%, respectively). The predominant dengue serotype varied by year: DEN-1 from 1990–92, DEN-2 from 1973–86 and 1988–89; DEN-3 in 1987 and 1995–99; and DEN-4 from 1993–94. Only DEN-3 was associated with severe outbreak years. Our findings illustrate the uniqueness of each serotype in producing epidemics and severe disease and underscore the importance of long-term surveillance of dengue serotypes in understanding the epidemiology of these viruses.

Author Notes

Reprint requests: Timothy P. Endy, Division of Virology, U.S. Army Medical Research Institute for Infectious Diseases, 1425 Porter St., Fort Detrick, MD 21702-5011
Copyright:
Copyright 2003 The American Society of Tropical Medicine 2003
Received:
17 Jan 2002
|
Accepted:
29 Aug 2002
|
Published Online:
Feb 2003
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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