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Reference Manager
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-
1
Shankar AH, 2000. Nutritional modulation of malaria morbidity and mortality. J Infect Dis 182 (Suppl. 1) :S37–S53.
-
2
Kaikai P, Thurnham DI, 1983. The influence of riboflavin deficiency on Plasmodium berghei infection in rats. Trans R Soc Trop Med Hyg 77 :680–686.
-
3
Seeler AO, Ott WH, 1944. Effect of riboflavin deficiency on the course of Plasmodium lophurae infection in chicks. J Infect Dis 75 :175–178.
-
4
Thurnham DI, Oppenheimer SJ, Bull R, 1983. Riboflavin status and malaria in infants in Papua New Guinea. Trans R Soc Trop Med Hyg 77 :423–424.
-
5
Das BS, Das DB, Satpathy RN, Patnaik JK, Bose TK, 1988. Riboflavin deficiency and severity of malaria. Eur J Clin Nutr 42 :277–283.
-
6
Das BS, Thurnham DI, Patnaik JK, Das DB, Satpathy RN, Bose TK, 1990. Increased plasma lipid peroxidation in riboflavin-deficient, malaria-infected children. Am J Clin Nutr 51 :859–863.
-
7
Tillotson JA, Baker EM, 1972. An enzymatic measurement of the riboflavin status in man. Am J Clin Nutr 25 :425–431.
-
8
Anderson BB, Giuberti M, Perry GM, Salsini G, Casadio I, Vullo C, 1993. Low red blood cell glutathione reductase and pyridoxine phosphate oxidase activities not related to dietary riboflavin: selection by malaria? Am J Clin Nutr 57 :666–672.
-
9
Combs GF, 1998. Riboflavin. The Vitamins, 2nd ed. San Diego: Academic Press, 295–310.
-
10
Capo-chichi CD, Guéant JL, Feillet F, Namour F, Vidailhet M, 2000. Analysis of riboflavin and riboflavin cofactor levels in plasma by high-performance liquid chromatography. J Chromatogr B 739 :219–224.
-
11
Capo-chichi CD, Guéant J, Lefebvre E, Bennani N, Lorentz E, Vidailhet C, Vidailhet M, 1999. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa. Am J Clin Nutr 71 :978–986.
-
12
Wildling E, Winkler S, Kremsner PG, Brandts C, Jenne L, Wernsdorfer WH, 1995. Malaria epidemiology in the province of Moyen Ogooué, Gabon. Trop Med Parasitol 46 :77–82.
-
13
Luckner D, Lell B, Greve B, Lehman LG, Matousek B, Greve B, Kremsner PG, 1998. No influence of socioeconomic factors on severe malarial anaemia, hyperparasitaemia or reinfection. Trans R Soc Trop Med Hyg 92 :478–481.
-
14
Kremsner PG, Radloff P, Metzger W, Wildling E, Mordmüller B, Phillipps J, Jenne L, Nkeyi M, Bienzle U, Graninger W, 1995. Quinine plus clindamycin improves chemotherapy of severe malaria in children. Antimicrob Agents Chemother 39 :1603–1605.
-
15
Schmidt-Ott R, Luckner D, Lehmann LG, Lell B, Matousek P, Greve B, Kremsner PG, 1997. Sulfadoxine/pyrimethamine for treating uncomplicated Plasmodium falciparum malaria in young children. Trans R Soc Trop Med Hyg 91 :578–579.
-
16
Lopez-Anaya A, Mayersohn M, 1987. Quantification of riboflavin, riboflavin 5′-phosphate and flavin adenin dinucleotide in plasma and urine by high-performance liquid chromatography. J Chromatogr 423 :105–113.
-
17
Winkler S, Willheim M, Baier K, Schmid D, Aichelburg A, Graninger W, Kremsner PG, 1999. Frequency of cytokine-producing T cells in patients of different age groups with Plasmodium falciparum malaria. J Infect Dis 179 :209–216.
-
18
Clements JE, Anderson BB, 1980. Glutathione reductase activity and pyridoxine (pyridoxamine) phosphate oxidase activity in the red cell. Biochim Biophys Acta 632 :159–163.
-
19
Beutler E, 1969. Effect of flavin compounds on glutathione reductase activity: in vivo and in vitro studies. J Clin Invest 48 :1957–1966.
-
20
Loos H, Roos D, Weening R, Houwerzijl J, 1976. Familial deficiency of glutathione reductase in human blood cells. Blood 48 :53–62.
-
21
Dutta P, Pinto J, Rivlin R, 1985. Antimalarial effects of riboflavin deficiency. Lancet 2 :1040–1043.
-
22
Zhang Y, Hempelmann E, Schirmer RH, 1988. Glutathione reductase inhibitors as potential antimalarial drugs. Biochem Pharmacol 37 :855–860.
-
23
Eckman JR, Eaton JW, 1979. Dependence of plasmodial glutathione metabolism on the host cell. Nature 278 :754–756.
-
24
Akompong T, Ghori N, Haldar K, 2000. In vitro activity of riboflavin against the human malaria parasite Plasmodium falciparum.Antimicrob Agents Chemother 44 :88–96.
-
25
Osuntokun B, Aladetoyinbo A, Bademosi O, 1985. Vitamin B nutrition in the Nigerian tropical ataxic neuropathy. J Neurol Neurosurg Psychiatry 48 :154–156.
-
26
Bamji MS, Bhaskaram P, Jacob CM, 1987. Urinary riboflavin excretion and erythrocyte glutathione reductase activity in preschool children suffering from upper respiratory infections and measles. Ann Nutr Metab 31 :191–196.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1157 | 1069 | 373 |
| Full Text Views | 282 | 7 | 0 |
| PDF Downloads | 66 | 8 | 0 |
NORMAL RIBOFLAVIN STATUS IN MALARIA PATIENTS IN GABON
FRIEDERIKE TRAUNMÜLLER
FRIEDERIKE TRAUNMÜLLER
Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Vienna, Austria; Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Department of Human Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany
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MICHAEL RAMHARTER
MICHAEL RAMHARTER
Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Vienna, Austria; Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Department of Human Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany
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HEIMO LAGLER
HEIMO LAGLER
Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Vienna, Austria; Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Department of Human Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany
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FLORIAN THALHAMMER
FLORIAN THALHAMMER
Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Vienna, Austria; Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Department of Human Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany
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PETER G. KREMSNER
PETER G. KREMSNER
Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Vienna, Austria; Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Department of Human Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany
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WOLFGANG GRANINGER
WOLFGANG GRANINGER
Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Vienna, Austria; Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Department of Human Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany
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STEFAN WINKLER
STEFAN WINKLER
Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Vienna, Austria; Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Department of Human Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany
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Previous publications reported commonly the occurrence of riboflavin deficiency and a positive correlation between riboflavin status and parasitemia in patients with Plasmodium falciparum malaria. In these studies, riboflavin status was determined by erythrocyte glutathione reductase activation coefficients (EGRACs). Inherited low erythrocyte glutathione reductase activity is highly prevalent in malarial regions, however. To rule out falsely diagnosed riboflavin deficiency in affected patients, we conducted an investigation using a high-performance liquid chromatography method (HPLC) instead of the EGRAC method. In 29 infants (age range, 1–5 years), 22 schoolchildren (age range, 6–12 years), and 33 adolescents and adults (age range, 13–74 years) from Lambaréné, Gabon, with acute P. falciparum malaria, plasma concentrations of riboflavin, flavin mononucleotide (FMN), and flavin adenine dinucleotide (FAD) were measured by HPLC. Results were correlated with parasite densities. Profiles of plasma concentrations of all 3 flavin compounds were within the normal range in all patients. Concentrations of free riboflavin were not different between the 3 age groups. In adolescents and adults, FMN and FAD concentrations were higher than in infants (P = 0.002 and P = 0.001) and schoolchildren (P = 0.003 and P = 0.002). Comparing children with hyperparasitemic and uncomplicated malaria, no difference in the concentrations of either flavin compound was found. Neither the concentrations of free riboflavin nor the concentrations of one of the flavin nucleotides correlated with parasitemia within subgroups of age or of children with uncomplicated and hyperparasitemic malaria. Our data indicate that nutritional riboflavin deficiency might have been overestimated in previous malaria studies and do not support a relationship between flavin concentrations and parasitemia in P. falciparum malaria.
Author Notes
ProCite
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Reference Manager
BibTeX
Zotero
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-
1
Shankar AH, 2000. Nutritional modulation of malaria morbidity and mortality. J Infect Dis 182 (Suppl. 1) :S37–S53.
-
2
Kaikai P, Thurnham DI, 1983. The influence of riboflavin deficiency on Plasmodium berghei infection in rats. Trans R Soc Trop Med Hyg 77 :680–686.
-
3
Seeler AO, Ott WH, 1944. Effect of riboflavin deficiency on the course of Plasmodium lophurae infection in chicks. J Infect Dis 75 :175–178.
-
4
Thurnham DI, Oppenheimer SJ, Bull R, 1983. Riboflavin status and malaria in infants in Papua New Guinea. Trans R Soc Trop Med Hyg 77 :423–424.
-
5
Das BS, Das DB, Satpathy RN, Patnaik JK, Bose TK, 1988. Riboflavin deficiency and severity of malaria. Eur J Clin Nutr 42 :277–283.
-
6
Das BS, Thurnham DI, Patnaik JK, Das DB, Satpathy RN, Bose TK, 1990. Increased plasma lipid peroxidation in riboflavin-deficient, malaria-infected children. Am J Clin Nutr 51 :859–863.
-
7
Tillotson JA, Baker EM, 1972. An enzymatic measurement of the riboflavin status in man. Am J Clin Nutr 25 :425–431.
-
8
Anderson BB, Giuberti M, Perry GM, Salsini G, Casadio I, Vullo C, 1993. Low red blood cell glutathione reductase and pyridoxine phosphate oxidase activities not related to dietary riboflavin: selection by malaria? Am J Clin Nutr 57 :666–672.
-
9
Combs GF, 1998. Riboflavin. The Vitamins, 2nd ed. San Diego: Academic Press, 295–310.
-
10
Capo-chichi CD, Guéant JL, Feillet F, Namour F, Vidailhet M, 2000. Analysis of riboflavin and riboflavin cofactor levels in plasma by high-performance liquid chromatography. J Chromatogr B 739 :219–224.
-
11
Capo-chichi CD, Guéant J, Lefebvre E, Bennani N, Lorentz E, Vidailhet C, Vidailhet M, 1999. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa. Am J Clin Nutr 71 :978–986.
-
12
Wildling E, Winkler S, Kremsner PG, Brandts C, Jenne L, Wernsdorfer WH, 1995. Malaria epidemiology in the province of Moyen Ogooué, Gabon. Trop Med Parasitol 46 :77–82.
-
13
Luckner D, Lell B, Greve B, Lehman LG, Matousek B, Greve B, Kremsner PG, 1998. No influence of socioeconomic factors on severe malarial anaemia, hyperparasitaemia or reinfection. Trans R Soc Trop Med Hyg 92 :478–481.
-
14
Kremsner PG, Radloff P, Metzger W, Wildling E, Mordmüller B, Phillipps J, Jenne L, Nkeyi M, Bienzle U, Graninger W, 1995. Quinine plus clindamycin improves chemotherapy of severe malaria in children. Antimicrob Agents Chemother 39 :1603–1605.
-
15
Schmidt-Ott R, Luckner D, Lehmann LG, Lell B, Matousek P, Greve B, Kremsner PG, 1997. Sulfadoxine/pyrimethamine for treating uncomplicated Plasmodium falciparum malaria in young children. Trans R Soc Trop Med Hyg 91 :578–579.
-
16
Lopez-Anaya A, Mayersohn M, 1987. Quantification of riboflavin, riboflavin 5′-phosphate and flavin adenin dinucleotide in plasma and urine by high-performance liquid chromatography. J Chromatogr 423 :105–113.
-
17
Winkler S, Willheim M, Baier K, Schmid D, Aichelburg A, Graninger W, Kremsner PG, 1999. Frequency of cytokine-producing T cells in patients of different age groups with Plasmodium falciparum malaria. J Infect Dis 179 :209–216.
-
18
Clements JE, Anderson BB, 1980. Glutathione reductase activity and pyridoxine (pyridoxamine) phosphate oxidase activity in the red cell. Biochim Biophys Acta 632 :159–163.
-
19
Beutler E, 1969. Effect of flavin compounds on glutathione reductase activity: in vivo and in vitro studies. J Clin Invest 48 :1957–1966.
-
20
Loos H, Roos D, Weening R, Houwerzijl J, 1976. Familial deficiency of glutathione reductase in human blood cells. Blood 48 :53–62.
-
21
Dutta P, Pinto J, Rivlin R, 1985. Antimalarial effects of riboflavin deficiency. Lancet 2 :1040–1043.
-
22
Zhang Y, Hempelmann E, Schirmer RH, 1988. Glutathione reductase inhibitors as potential antimalarial drugs. Biochem Pharmacol 37 :855–860.
-
23
Eckman JR, Eaton JW, 1979. Dependence of plasmodial glutathione metabolism on the host cell. Nature 278 :754–756.
-
24
Akompong T, Ghori N, Haldar K, 2000. In vitro activity of riboflavin against the human malaria parasite Plasmodium falciparum.Antimicrob Agents Chemother 44 :88–96.
-
25
Osuntokun B, Aladetoyinbo A, Bademosi O, 1985. Vitamin B nutrition in the Nigerian tropical ataxic neuropathy. J Neurol Neurosurg Psychiatry 48 :154–156.
-
26
Bamji MS, Bhaskaram P, Jacob CM, 1987. Urinary riboflavin excretion and erythrocyte glutathione reductase activity in preschool children suffering from upper respiratory infections and measles. Ann Nutr Metab 31 :191–196.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1157 | 1069 | 373 |
| Full Text Views | 282 | 7 | 0 |
| PDF Downloads | 66 | 8 | 0 |