Authors:
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1
Aramburu Guarda JC, Ramal Asayag C, Witzig R, 1999. Malaria reemergence in the Peruvian Amazon region. Emerg Infect Dis 5 :209–215.
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2
Panduro M, Colán E, Witzig R, Quintana J, Chávez R, 1997. In vitro and in vivo study of the response of P. falciparum to chloroquine, sulfadoxine/pyrimethamine, quinine, and mefloquine in peri-urban and rural Iquitos. Peruvian Soc Infect Trop Dis 6 :64.
-
3
Wongrichanalai C, Sirichaisinthop J, Karwacki JJ, Congpuong K, Miller RS, Pang L, Thimasam K, 2001. Drug resistant malaria on the Thai-Myanmar and Thai-Cambodian borders. Southeast Asian J Trop Med Public Health. 32 :41–49.
-
4
von Seidlen L, Milligan P, Pinder M, Bojang K, Anyalebechi C, Gosling R, Coleman R, Ude JI, Sadiq A, Duraisingh M, Warhurst D, Alloueche A, Targett G, McAdam K, Greenwood B, Walraven G, Olliaro P, Doherty T, 2000. Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial. Lancet. 355 :352–357.
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5
Pearlman EJ, Doberstyn EB, Sudsok S, Thiemanun W, Kennedy RS, Canfield CJ, 1980. Chemosuppressive field trials in Thailand. IV. The suppression of Plasmodium falciparum and Plasmodium vivax parasitemias by mefloquine (WR 142,490, A 4-quinolinemethanol). Am J Trop Med Hyg. 29 :1131–1137.
-
6
Nosten F, van Vugt M, Price R, Luxemburger C, Thway KL, Brockman A, McGready R, ter Kuile F, Looareesuwan S, White NJ, 2000. Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. Lancet 356 :297–302.
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7
Reed MB, Saliba KJ, Caruana SR, Kirk K, Cowman AF, 2000. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 403 :906–909.
-
8
Duraisingh MT, Roper C, Walliker D, Warhurst DC, 2000. Increased sensitivity to the antimalarials mefloquine and arte-misinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum. Mol Microbiol 36 :955–961.
-
9
WHO, 1994. Antimalarial Drug Policies: Data Requirements, Treatment of Uncomplicated Malaria and Management of Malaria in Pregnancy. Geneva: World Health Organization, WHO/MAL/94.1070.
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10
Price RN, Cassar C, Brockman A, Duraisingh M, van Vugt M, White NJ, Nosten F, Krishna S, 1999. The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. Anti-microb Agents Chemother 43 :2943–2949.
-
11
Sanger F, Nicklen S, Coulson AR, 1977. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74 :5463–5467.
-
12
Calvosa VS, Adagu IS, Povoa MM, 2001. Plasmodium falciparum: emerging mefloquine resistance in vitro in Para State, north Brazil. Trans R Soc Trop Med Hyg 95 :330–331.
-
13
Wellems TE, Plowe CV, 2001. Chloroquine-resistant malaria. J Infect Dis 184 :770–776.
-
14
Babiker HA, Pringle SJ, Abdel-Muhsin A, Mackinnon M, Hunt P, Walliker D, 2001. High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance gene pfmdr1. J Infect Dis 183 :1535–1538.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 580 | 519 | 125 |
| Full Text Views | 226 | 9 | 1 |
| PDF Downloads | 63 | 8 | 0 |
LACK OF PREDICTION OF MEFLOQUINE AND MEFLOQUINE-ARTESUNATE TREATMENT OUTCOME BY MUTATIONS IN THE PLASMODIUM FALCIPARUM MULTIDRUG RESISTANCE 1 (PFMDR1) GENE FOR PLASMODIUM FALCIPARUM MALARIA IN PERU
DYLAN R. PILLAI
DYLAN R. PILLAI
Tropical Disease Unit, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada; Instituto Nacional de Salud, Lima, Peru; U.S. Naval Medical Research Center Detachment, Lima, Peru; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
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GISELY HIJAR
GISELY HIJAR
Tropical Disease Unit, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada; Instituto Nacional de Salud, Lima, Peru; U.S. Naval Medical Research Center Detachment, Lima, Peru; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
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YSABEL MONTOYA
YSABEL MONTOYA
Tropical Disease Unit, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada; Instituto Nacional de Salud, Lima, Peru; U.S. Naval Medical Research Center Detachment, Lima, Peru; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
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WILMER MARQUIÑO
WILMER MARQUIÑO
Tropical Disease Unit, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada; Instituto Nacional de Salud, Lima, Peru; U.S. Naval Medical Research Center Detachment, Lima, Peru; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
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TRENTON K. RUEBUSH II
TRENTON K. RUEBUSH II
Tropical Disease Unit, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada; Instituto Nacional de Salud, Lima, Peru; U.S. Naval Medical Research Center Detachment, Lima, Peru; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
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CHANSUDA WONGSRICHANALAI
CHANSUDA WONGSRICHANALAI
Tropical Disease Unit, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada; Instituto Nacional de Salud, Lima, Peru; U.S. Naval Medical Research Center Detachment, Lima, Peru; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
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KEVIN C. KAIN
KEVIN C. KAIN
Tropical Disease Unit, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada; Instituto Nacional de Salud, Lima, Peru; U.S. Naval Medical Research Center Detachment, Lima, Peru; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
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We assessed whether mutations in the Plasmodium falciparum multidrug-resistance gene 1 (pfmdr1) (C1034S, D1042N, and Y1246D) would predict treatment outcome during a 28-day in vivo treatment trial in the Peruvian Amazon. Mefloquine (MQ) was compared with mefloquine-artesunate (MQ-AS) in a randomized, multi-clinic protocol for the first time in the Americas. Of 115 patients enrolled in the in vivo arm, 97 patients were eligible for molecular analysis. All 97 patients remained parasite-free during 28 days of follow-up (MQ, n = 46; MQ-AS, n = 51), indicating 100% clinical efficacy of the MQ and MQ-AS treatment regimens. The reported MQ-sensitive alleles (C1034, D1042, and Y1246) were present in 48.5% (n = 47) of the cases, whereas 49 isolates (50.5%) contained the D1246 mutation reported to confer MQ resistance in vitro. However, neither this mutation nor a double mutation (S1034, D1246; n = 16) was predictive of MQ treatment outcome.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
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-
1
Aramburu Guarda JC, Ramal Asayag C, Witzig R, 1999. Malaria reemergence in the Peruvian Amazon region. Emerg Infect Dis 5 :209–215.
-
2
Panduro M, Colán E, Witzig R, Quintana J, Chávez R, 1997. In vitro and in vivo study of the response of P. falciparum to chloroquine, sulfadoxine/pyrimethamine, quinine, and mefloquine in peri-urban and rural Iquitos. Peruvian Soc Infect Trop Dis 6 :64.
-
3
Wongrichanalai C, Sirichaisinthop J, Karwacki JJ, Congpuong K, Miller RS, Pang L, Thimasam K, 2001. Drug resistant malaria on the Thai-Myanmar and Thai-Cambodian borders. Southeast Asian J Trop Med Public Health. 32 :41–49.
-
4
von Seidlen L, Milligan P, Pinder M, Bojang K, Anyalebechi C, Gosling R, Coleman R, Ude JI, Sadiq A, Duraisingh M, Warhurst D, Alloueche A, Targett G, McAdam K, Greenwood B, Walraven G, Olliaro P, Doherty T, 2000. Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial. Lancet. 355 :352–357.
-
5
Pearlman EJ, Doberstyn EB, Sudsok S, Thiemanun W, Kennedy RS, Canfield CJ, 1980. Chemosuppressive field trials in Thailand. IV. The suppression of Plasmodium falciparum and Plasmodium vivax parasitemias by mefloquine (WR 142,490, A 4-quinolinemethanol). Am J Trop Med Hyg. 29 :1131–1137.
-
6
Nosten F, van Vugt M, Price R, Luxemburger C, Thway KL, Brockman A, McGready R, ter Kuile F, Looareesuwan S, White NJ, 2000. Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. Lancet 356 :297–302.
-
7
Reed MB, Saliba KJ, Caruana SR, Kirk K, Cowman AF, 2000. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 403 :906–909.
-
8
Duraisingh MT, Roper C, Walliker D, Warhurst DC, 2000. Increased sensitivity to the antimalarials mefloquine and arte-misinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum. Mol Microbiol 36 :955–961.
-
9
WHO, 1994. Antimalarial Drug Policies: Data Requirements, Treatment of Uncomplicated Malaria and Management of Malaria in Pregnancy. Geneva: World Health Organization, WHO/MAL/94.1070.
-
10
Price RN, Cassar C, Brockman A, Duraisingh M, van Vugt M, White NJ, Nosten F, Krishna S, 1999. The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. Anti-microb Agents Chemother 43 :2943–2949.
-
11
Sanger F, Nicklen S, Coulson AR, 1977. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74 :5463–5467.
-
12
Calvosa VS, Adagu IS, Povoa MM, 2001. Plasmodium falciparum: emerging mefloquine resistance in vitro in Para State, north Brazil. Trans R Soc Trop Med Hyg 95 :330–331.
-
13
Wellems TE, Plowe CV, 2001. Chloroquine-resistant malaria. J Infect Dis 184 :770–776.
-
14
Babiker HA, Pringle SJ, Abdel-Muhsin A, Mackinnon M, Hunt P, Walliker D, 2001. High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance gene pfmdr1. J Infect Dis 183 :1535–1538.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 580 | 519 | 125 |
| Full Text Views | 226 | 9 | 1 |
| PDF Downloads | 63 | 8 | 0 |