Defective production of reactive oxygen intermediates (ROI) in a patient with recurrent amebic liver abscess.

Patricia Morán Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, DF México.

Search for other papers by Patricia Morán in
Current site
Google Scholar
PubMed Close
,
Guadalupe Rico Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, DF México.

Search for other papers by Guadalupe Rico in
Current site
Google Scholar
PubMed Close
,
Manuel Ramiro Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, DF México.

Search for other papers by Manuel Ramiro in
Current site
Google Scholar
PubMed Close
,
Horacio Olvera Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, DF México.

Search for other papers by Horacio Olvera in
Current site
Google Scholar
PubMed Close
,
Fernando Ramos Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, DF México.

Search for other papers by Fernando Ramos in
Current site
Google Scholar
PubMed Close
,
Enrique González Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, DF México.

Search for other papers by Enrique González in
Current site
Google Scholar
PubMed Close
,
Alicia Valadéz Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, DF México.

Search for other papers by Alicia Valadéz in
Current site
Google Scholar
PubMed Close
,
Octavio Curiel Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, DF México.

Search for other papers by Octavio Curiel in
Current site
Google Scholar
PubMed Close
,
Emma I Melendro Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, DF México.

Search for other papers by Emma I Melendro in
Current site
Google Scholar
PubMed Close
, and
Cecilia Ximénez Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, DF México.

Search for other papers by Cecilia Ximénez in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.2002.67.632
Volume/Issue:
Volume 67: Issue 6
Page(s):
632–635
Restricted access
Get Permissions

Previously, we reported the case of a man in the fourth decade of life afflicted with three independent episodes of amebic liver abscesses over a period of 4 years. Previous evidence has indicated that the cellular immune response is involved in protection against recurrent invasive amebic infection, and macrophage-mediated effector mechanisms appear important for host resistance to Entamoeba histolytica infection. The aim of the present work was to investigate locomotor activity and oxidative burst function of peripheral mononuclear cells of this individual after healing of the third amebic liver abscess. A locomotion assay using Boyden chemotaxis chambers and the respiratory burst evaluated by chemiluminescence were performed in both mononuclear phagocytes (MPs) and polymorphonuclear (PMN) leukocytes. Levels of salivary IgA and serum IgG anti-amebic antibodies were followed during 48 months after the second amebic liver abscess. Results obtained showed a deficiency in MP but not in PMN leukocyte respiratory burst. Respiratory burst is a major microbicidal mechanism in MP leukocytes; this also has been considered as a host resistance strategy against E. histolytica. It may be at least one risk factor in our patient that was responsible for recurrence of amebic liver abscess.

Author Notes

Published Online:
Dec 2002
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 583 535 26
Full Text Views 336 5 0
PDF Downloads 69 8 0
 

 

 

 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save