A biologic basis for integrated malaria control.

F Ellis McKenzie Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA. mckenzel@mail.nih.gov

Search for other papers by F Ellis McKenzie in
Current site
Google Scholar
PubMed Close
,
J Kevin Baird Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA. mckenzel@mail.nih.gov

Search for other papers by J Kevin Baird in
Current site
Google Scholar
PubMed Close
,
John C Beier Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA. mckenzel@mail.nih.gov

Search for other papers by John C Beier in
Current site
Google Scholar
PubMed Close
,
Altaf A Lal Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA. mckenzel@mail.nih.gov

Search for other papers by Altaf A Lal in
Current site
Google Scholar
PubMed Close
, and
William H Bossert Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892, USA. mckenzel@mail.nih.gov

Search for other papers by William H Bossert in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.2002.67.571
Volume/Issue:
Volume 67: Issue 6
Page(s):
571–577
Restricted access
Get Permissions

In a series of models of Plasmodium falciparum dynamics, spontaneous local extinctions of the parasite sometimes occurred under steady, perennial-transmission conditions. These extinctions occurred only with extremely low mosquito densities or when the parameter describing the duration of human infection-blocking immunity was at its maximum value, and, simultaneously, those describing vector survivorship and the duration of human infectivity were at their minimum values. The range and frequency of extinctions increased with seasonal transmission, and decreased with the emergence of recombinant genotypes. Here we extend the immunity parameter up to levels that would describe a successful vaccine, and examine the combined influences of seasonality, genotype cross-reactivity, meiotic recombination, and human population turnover on parasite persistence. As Ross did 90 years ago, we conclude that malaria control programs that encompass several methods and targets of intervention are the most likely to succeed. Success is more likely if programs are cognizant of local circumstances of transmission, and, within that context, aim to reduce vector survivorship and human infectivity as well as augment human immunity.

Published Online:
Dec 2002
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 10 10 3
Full Text Views 234 92 0
PDF Downloads 42 21 0
 
Membership Banner
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save