Past two years Past Year Past 30 Days
Abstract Views 4 4 4
Full Text Views 267 135 1
PDF Downloads 76 42 1
 
 
 
 
 
 
 
 
 
 
 

Exacerbation of HIV viral load simultaneous with asymptomatic reactivation of chronic Chagas' disease.

Ana Marli C SartoriClinic of Infectious and Parasitic Diseases/AIDS Clinic, Central Laboratory Division, Laboratory of Medical Investigation of Parasitology, Hospital das Clínicas, São Paulo, Brazil. amsartori@sti.com.br

Search for other papers by Ana Marli C Sartori in
Current site
Google Scholar
PubMed
Close
,
Hélio H Caiaffa-FilhoClinic of Infectious and Parasitic Diseases/AIDS Clinic, Central Laboratory Division, Laboratory of Medical Investigation of Parasitology, Hospital das Clínicas, São Paulo, Brazil. amsartori@sti.com.br

Search for other papers by Hélio H Caiaffa-Filho in
Current site
Google Scholar
PubMed
Close
,
Rita C BezerraClinic of Infectious and Parasitic Diseases/AIDS Clinic, Central Laboratory Division, Laboratory of Medical Investigation of Parasitology, Hospital das Clínicas, São Paulo, Brazil. amsartori@sti.com.br

Search for other papers by Rita C Bezerra in
Current site
Google Scholar
PubMed
Close
,
Carmem do S GuilhermeClinic of Infectious and Parasitic Diseases/AIDS Clinic, Central Laboratory Division, Laboratory of Medical Investigation of Parasitology, Hospital das Clínicas, São Paulo, Brazil. amsartori@sti.com.br

Search for other papers by Carmem do S Guilherme in
Current site
Google Scholar
PubMed
Close
,
Marta H LopesClinic of Infectious and Parasitic Diseases/AIDS Clinic, Central Laboratory Division, Laboratory of Medical Investigation of Parasitology, Hospital das Clínicas, São Paulo, Brazil. amsartori@sti.com.br

Search for other papers by Marta H Lopes in
Current site
Google Scholar
PubMed
Close
, and
Maria Aparecida Shikanai-YasudaClinic of Infectious and Parasitic Diseases/AIDS Clinic, Central Laboratory Division, Laboratory of Medical Investigation of Parasitology, Hospital das Clínicas, São Paulo, Brazil. amsartori@sti.com.br

Search for other papers by Maria Aparecida Shikanai-Yasuda in
Current site
Google Scholar
PubMed
Close
View More View Less
Restricted access

Chronic Trypanosoma cruzi infection can reactivate in patients with immunosuppression related to human immunodeficiency virus (HIV) infection, resulting in severe meningoencephalitis or myocarditis and high parasitemia. The effects of T. cruzi on HIV infection are unknown. We describe an HIV-infected patient with chronic Chagas' disease who experienced an asymptomatic T. cruzi reactivation characterized by the finding of the parasite in direct microscopic examination of blood. The patient's HIV viral load had increased simultaneously with the exacerbation of T. cruzi parasitemia and decreased to previous levels after successful antiparasitic treatment. This otherwise unexplained finding suggests that T. cruzi infection might up-regulate HIV replication, which may affect HIV disease progression. Asymptomatic reactivation of Chagas' disease has not been reported before. This could mean that the severe clinical manifestations related to the reactivation of trypanosomiasis are just the tip of the iceberg.

Save