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The importance of leptospirosis in Southeast Asia.
Kanti Laras
Kanti Laras
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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Bao Van Cao
Bao Van Cao
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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Khanthong Bounlu
Khanthong Bounlu
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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Thi Kim Tien Nguyen
Thi Kim Tien Nguyen
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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James G Olson
James G Olson
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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Sisouk Thongchanh
Sisouk Thongchanh
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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Nguyen Van Anh Tran
Nguyen Van Anh Tran
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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Kim Loan Hoang
Kim Loan Hoang
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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Narain Punjabi
Narain Punjabi
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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Ba Khiem Ha
Ba Khiem Ha
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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Sam An Ung
Sam An Ung
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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Sithat Insisiengmay
Sithat Insisiengmay
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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Douglas M Watts
Douglas M Watts
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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H James Beecham
H James Beecham
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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Andrew L Corwin
Andrew L Corwin
U.S. Naval Medical Research Unit No. 2, Jakarta, Indonesia.
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The importance of leptospirosis in Southeast Asia was assessed in conjunction with other studies supported by the U.S. Naval Medical Research Unit No. 2 (US NAMRU-2), Jakarta, Republic of Indonesia. These included studies of hospital-based, acute clinical jaundice in Indonesia, Lao PDR, and Socialist Republic of Vietnam; nonmalarial fever in Indonesia; and hemorrhagic fever in Cambodia. Background prevalence estimates of leptospiral infection were obtained by a cross-sectional, community-based study in Lao PDR. Laboratory testing methods involved serology, microscopic agglutination test, and reverse-transcriptase polymerase chain reaction. Suggestive evidence of recent leptospiral infections was detected in 17%, 13%, and 3% of patients selected on the basis of non-hepatitis A through E jaundice, nonmalarial fever, and hemorrhagic fever (in the absence of acute, dengue viral infections). Leptospiral IgG antibody, reflective of prior infections, was detected in 37% of human sera, collected in Lao PDR. The predominant leptospiral serogroups identified from cases with clinical jaundice were Hurstbridge, Bataviae, and Icterohaemorrhagiae tonkini LT 96 69. Among the nonmalarial febrile cases, Bataviae was the most frequently recognized serogroup. Pyrogenes and Hurstbridge were the principal serogroups among the hemorrhagic fever case subjects. These findings further attest to the relative importance of clinical leptospirosis in Southeast Asia. The wide spectrum of clinical signs and symptoms associated with probable, acute, leptospiral infections contributes to the potential of significant underreporting.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 43 | 43 | 11 |
| Full Text Views | 218 | 126 | 1 |
| PDF Downloads | 114 | 73 | 0 |