Short report: therapeutic efficacy of chloroquine combined with primaquine against Plasmodium falciparum in northeastern Papua, Indonesia.

J Kevin Baird US Naval Medical Research Unit No 2, American Embassy Jakarta, Indonesia. bairdjk@namru2.med.navy.mil

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Iwa Wiady US Naval Medical Research Unit No 2, American Embassy Jakarta, Indonesia. bairdjk@namru2.med.navy.mil

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Awalludin Sutanihardja US Naval Medical Research Unit No 2, American Embassy Jakarta, Indonesia. bairdjk@namru2.med.navy.mil

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Suradi US Naval Medical Research Unit No 2, American Embassy Jakarta, Indonesia. bairdjk@namru2.med.navy.mil

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Purnomo US Naval Medical Research Unit No 2, American Embassy Jakarta, Indonesia. bairdjk@namru2.med.navy.mil

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Hasan Basri US Naval Medical Research Unit No 2, American Embassy Jakarta, Indonesia. bairdjk@namru2.med.navy.mil

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Sekartuti US Naval Medical Research Unit No 2, American Embassy Jakarta, Indonesia. bairdjk@namru2.med.navy.mil

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Ester Ayomi US Naval Medical Research Unit No 2, American Embassy Jakarta, Indonesia. bairdjk@namru2.med.navy.mil

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David J Fryauff US Naval Medical Research Unit No 2, American Embassy Jakarta, Indonesia. bairdjk@namru2.med.navy.mil

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Stephen L Hoffman US Naval Medical Research Unit No 2, American Embassy Jakarta, Indonesia. bairdjk@namru2.med.navy.mil

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DOI:
https://doi.org/10.4269/ajtmh.2002.66.659
Volume/Issue:
Volume 66: Issue 6
Page(s):
659–660
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Chloroquine combined with primaquine was evaluated for therapy of uncomplicated malaria caused by Plasmodium falciparum in nonimmune Javanese migrants to northeastern Papua, Indonesia. Subjects were randomized to treatment with standard chloroquine therapy (25 mg/kg in 3 doses over the course of 48 hours) with 30 mg primaquine administered daily for 28 days (n = 25) or a placebo of primaquine (n = 28). The 14-day cumulative incidence of therapeutic failure was 56% with primaquine and 79% with placebo (odds ratio [OR], 0.35; 95% confidence interval [CI], 0.1-1.3; P = 0.08). Primaquine administered daily created a marginally significant improvement in therapeutic efficacy at day 14, but not at day 7 (20% versus 36%; OR, 0.2; 95% CI, 0.1-1.8; P = 0.2) or day 28 (82% versus 93%; OR, 0.31; 95% Cl, 0.04-2.1; P = 0.23). This report corroborates studies suggesting that therapeutic doses of primaquine exert no discernible effect on parasitemia by P. falciparum.

Author Notes

Published Online:
Jun 2002
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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