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New emerging Plasmodium falciparum genotypes in children during the transition phase from asymptomatic parasitemia to malaria.
Jürgen F J Kun
Jürgen F J Kun
Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Germany. juergen.kun@uni-tuebingen.de
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Michel A Missinou
Michel A Missinou
Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Germany. juergen.kun@uni-tuebingen.de
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Bertrand Lell
Bertrand Lell
Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Germany. juergen.kun@uni-tuebingen.de
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Milena Sovric
Milena Sovric
Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Germany. juergen.kun@uni-tuebingen.de
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Hanna Knoop
Hanna Knoop
Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Germany. juergen.kun@uni-tuebingen.de
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Birgit Bojowald
Birgit Bojowald
Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Germany. juergen.kun@uni-tuebingen.de
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Oliver Dangelmaier
Oliver Dangelmaier
Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Germany. juergen.kun@uni-tuebingen.de
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Peter G Kremsner
Peter G Kremsner
Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Germany. juergen.kun@uni-tuebingen.de
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Semi-immunity against Plasmodium falciparum occurs after many infections. In areas of high malaria transmission, the prevalence of asymptomatic parasite carriers increases with age. We investigated P. falciparum genotypes in a cohort of asymptomatic carriers who were followed until they became symptomatic. Blood spots on filter paper and blood smears were collected daily from 10 children in Lambaréné, Gabon. The parasite genotypes present on successive days were determined by a polymerase chain reaction using the polymorphic region of the merozoite surface antigen-2 for typing. The same parasite genotypes persisted in eight out of ten children and parasite densities were low throughout the asymptomatic phase indicating inhibition of parasite growth. Appearance of symptoms was associated with an increase in parasitemia and appearance of novel parasite genotypes. The results suggest that the parasites causing a clinical episode are those against which a child has not yet mounted an efficient protective immune response.
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| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 476 | 422 | 27 |
| Full Text Views | 487 | 9 | 4 |
| PDF Downloads | 97 | 9 | 4 |