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Assessing the Parasight-F test in northeastern Papua, Indonesia, an area of mixed Plasmodium falciparum and Plasmodium vivax transmission.
Walter R J Taylor
Walter R J Taylor
US Naval Medical Research Unit No 2, Jakarta, Indonesia. Taylorw@who.ch
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Hendra Widjaja
Hendra Widjaja
US Naval Medical Research Unit No 2, Jakarta, Indonesia. Taylorw@who.ch
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Hasan Basri
Hasan Basri
US Naval Medical Research Unit No 2, Jakarta, Indonesia. Taylorw@who.ch
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David J Fryauff
David J Fryauff
US Naval Medical Research Unit No 2, Jakarta, Indonesia. Taylorw@who.ch
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Colin Ohrt
Colin Ohrt
US Naval Medical Research Unit No 2, Jakarta, Indonesia. Taylorw@who.ch
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Taufik
Taufik
US Naval Medical Research Unit No 2, Jakarta, Indonesia. Taylorw@who.ch
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Emiliana Tjitra
Emiliana Tjitra
US Naval Medical Research Unit No 2, Jakarta, Indonesia. Taylorw@who.ch
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Stephen L Hoffman
Stephen L Hoffman
US Naval Medical Research Unit No 2, Jakarta, Indonesia. Taylorw@who.ch
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Samuel Baso
Samuel Baso
US Naval Medical Research Unit No 2, Jakarta, Indonesia. Taylorw@who.ch
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Thomas L Richie
Thomas L Richie
US Naval Medical Research Unit No 2, Jakarta, Indonesia. Taylorw@who.ch
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User-friendly, reliable, and inexpensive methods for diagnosing malaria are needed at the primary health care level. During a randomized treatment trial, the Parasight-F test was assessed on days 0, 3, 7, and 28 against standard light microscopy of Giemsa-stained thick blood smears for diagnosing Plasmodium falciparum parasitemia in patients with P. falciparum (n = 84) or P. vivax (n = 59) malaria. The median P. falciparum parasite count on day 0 was 2,373/microL (range = 20-74,432/microL). At the start of treatment, the Parasight-F test had a sensitivity of 95.2% (80 of 84; 95% confidence interval [CI] = 88.2-98.7), and a specificity of 94.9% (56 of 59; 95% CI = 85.8-98.9). On day 7, this test showed false-positive results in 17 (16.3%) of 104 patients (95% CI = 9.8-24.9). The Parasight-F test performed well when compared with light microscopy in detecting P. falciparum parasitemia in patients presenting with clinical malaria. However, the high false-positive rate on day 7 limits its use for patient follow-up.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 26 | 26 | 13 |
| Full Text Views | 283 | 76 | 0 |
| PDF Downloads | 53 | 16 | 0 |