Parasitic load and histopathology of cutaneous lesions, lymph node, spleen, and liver from BALB/c and C57BL/6 mice infected with Leishmania mexicana.

Fabiola Aguilar Torrentera Laboratory of Parasitology, Free University of Brussels (ULB), Belgium.

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Marie-Alexandra Lambot Laboratory of Parasitology, Free University of Brussels (ULB), Belgium.

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Jon D Laman Laboratory of Parasitology, Free University of Brussels (ULB), Belgium.

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Marjan Van Meurs Laboratory of Parasitology, Free University of Brussels (ULB), Belgium.

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Robert Kiss Laboratory of Parasitology, Free University of Brussels (ULB), Belgium.

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Jean-Christophe Noël Laboratory of Parasitology, Free University of Brussels (ULB), Belgium.

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Yves Carlier Laboratory of Parasitology, Free University of Brussels (ULB), Belgium.

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DOI:
https://doi.org/10.4269/ajtmh.2002.66.273
Volume/Issue:
Volume 66: Issue 3
Page(s):
273–279
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The course of infection, parasitic loads, and histopathology of cutaneous lesions, draining lymph node, spleen, and liver were compared in BALB/c and C57BL/6 mice over a period of 34 weeks after inoculation in footpad with promastigotes of a Leishmania mexicana reference strain. The results show that the primary footpad lesions first present a 12-week phase that develops similarly in both strains of mice. Thereafter, a cutaneous and visceral dissemination of L. mexicana parasites occurs in BALB/c mice; the latter experience an extensive breakdown of the lymphoid organ microarchitecture, whereas C57BL/6 mice succeed in eliminating the parasite infection from the lymph nodes but not from the primary cutaneous lesion, which does not heal. These results highlight marked differences between responses of key anatomical compartments controlling L. mexicana infection in BALB/c and C57BL/6 mice.

Author Notes

Published Online:
Mar 2002
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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