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Association of helminth infection with decreased reticulocyte counts and hemoglobin concentration in Thai falciparum malaria.
M Nacher
M Nacher
Unité INSERM 511: Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, Faculté de médecine Pitié-Salpétrière, Paris, France. m_nacher@mailcity.com
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P Singhasivanon
P Singhasivanon
Unité INSERM 511: Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, Faculté de médecine Pitié-Salpétrière, Paris, France. m_nacher@mailcity.com
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F Gay
F Gay
Unité INSERM 511: Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, Faculté de médecine Pitié-Salpétrière, Paris, France. m_nacher@mailcity.com
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W Phumratanaprapin
W Phumratanaprapin
Unité INSERM 511: Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, Faculté de médecine Pitié-Salpétrière, Paris, France. m_nacher@mailcity.com
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U Silachamroon
U Silachamroon
Unité INSERM 511: Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, Faculté de médecine Pitié-Salpétrière, Paris, France. m_nacher@mailcity.com
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S Looareesuwan
S Looareesuwan
Unité INSERM 511: Immunobiologie Cellulaire et Moleculaire des Infections Parasitaires, Faculté de médecine Pitié-Salpétrière, Paris, France. m_nacher@mailcity.com
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Following a study showing an association between Ascaris and protection from cerebral malaria, we conducted a cross-sectional study comparing admission hemoglobin concentrations in relation to exposure to helminth infection in 2 separate groups of patients: 111 cerebral malaria cases and 180 mild Plasmodium falciparum malaria cases. Hookworm infections were excluded. Mean hemoglobin concentrations were significantly lower in helminth-infected patients compared to those without helminths, both in the cerebral malaria group (10.1+/-3 [n = 47] versus 11.2+/-2.4 g/dl [n = 64], P = 0.04) and the mild malaria group (11+/-2.5 [n = 89] vs 12.2+/-2.7 g/dl [n = 91], P = 0.004). Median reticulocyte counts, only available in the cerebral malaria group, were lower in helminth-infected patients compared to those without helminths (15,340/23,760 per microl, P = 0.03). Adjustments for confounders such as body mass index did not alter these associations. These data are consistent with a mechanism causing anemia linked to differences in the immune response of helminth-infected patients during malaria.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 49 | 49 | 10 |
| Full Text Views | 111 | 66 | 1 |
| PDF Downloads | 44 | 28 | 0 |