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Safety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancy.
R McGready
R McGready
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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K A Hamilton
K A Hamilton
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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J A Simpson
J A Simpson
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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T Cho
T Cho
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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C Luxemburger
C Luxemburger
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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R Edwards
R Edwards
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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S Looareesuwan
S Looareesuwan
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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N J White
N J White
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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F Nosten
F Nosten
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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S W Lindsay
S W Lindsay
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
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The safety of daily application of N, N-diethyl-m-toluamide (DEET) (1.7 g of DEET/day) in the second and third trimesters of pregnancy was assessed as part of a double-blind, randomized, therapeutic trial of insect repellents for the prevention of malaria in pregnancy (n = 897). No adverse neurologic, gastrointestinal, or dermatologic effects were observed for women who applied a median total dose of 214.2 g of DEET per pregnancy (range = 0-345.1 g). DEET crossed the placenta and was detected in 8% (95% confidence interval = 2.6-18.2) of cord blood samples from a randomly selected subgroup of DEET users (n = 50). No adverse effects on survival, growth, or development at birth, or at one year, were found. This is the first study to document the safety of DEET applied regularly in the second and third trimesters of pregnancy. The results suggest that the risk of DEET accumulating in the fetus is low and that DEET is safe to use in later pregnancy.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 119 | 119 | 31 |
| Full Text Views | 419 | 161 | 3 |
| PDF Downloads | 297 | 98 | 2 |