Seroepidemiology of toxoplasmosis in amerindians from western Venezuela.

L Chacin-Bonilla Instituto de Investigaciones Clínicas, Universidad del Zulia, Maracaibo, Venezuela. ebonilla@reacciun.ve

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Y Sanchez-Chavez Instituto de Investigaciones Clínicas, Universidad del Zulia, Maracaibo, Venezuela. ebonilla@reacciun.ve

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F Monsalve Instituto de Investigaciones Clínicas, Universidad del Zulia, Maracaibo, Venezuela. ebonilla@reacciun.ve

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J Estevez Instituto de Investigaciones Clínicas, Universidad del Zulia, Maracaibo, Venezuela. ebonilla@reacciun.ve

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DOI:
https://doi.org/10.4269/ajtmh.2001.65.131
Volume/Issue:
Volume 65: Issue 2
Page(s):
131–135
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A survey of 447 Amerindians aged 1-69 years (mean age, 18.6 +/- 15.8 years) in 3 mountain and 1 lowland communities from Venezuela were studied to determine the seroprevalence of Toxoplasma gondii, the environmental risk factors for the infection, and how the process of acculturation may affect the transmission rate. Serum samples were tested for immunoglobulin G antibodies by a commercial indirect hemagglutination test. The overall prevalence of infection was 49.7% (222 of 447) and ranged 38.2-62.4%. A higher antibody rate was found in the lowland setting as compared with those from the mountain area (P < 0.001). The geometric mean titer in the overall population was 280.3. No age-antibody association was detected in the mountain communities, although a gradual increase in positivity with increasing age (P < 0.01) was observed in the lowland setting, reaching a peak of 83.3% in the oldest group. The results suggest that transmission by infective cat feces may play a predominant role in the spread of infection in this population. This study demonstrates the environmental Toxoplasma infection pressure in this sylvatic population and how transmission rate is facilitated by environmental changes produced by acculturation.

Published Online:
Aug 2001
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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