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Antioxidant status and acute malaria in children in Kampala, Uganda.
A Metzger
A Metzger
Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA.
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G Mukasa
G Mukasa
Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA.
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A H Shankar
A H Shankar
Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA.
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G Ndeezi
G Ndeezi
Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA.
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G Melikian
G Melikian
Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA.
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R D Semba
R D Semba
Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA.
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Although antioxidant status has been implicated in the pathogenesis of malaria, these factors need further characterization. A longitudinal study was conducted involving 273 children 1-10 years of age with acute, uncomplicated malaria in Kampala, Uganda. Plasma vitamin A, carotenoids, and vitamin E were measured at enrollment and on day 7. Malaria parasitemia was measured at enrollment, on day 3, and on day 7. Malaria parasitemia had completely cleared in 57.1% and 85.3% of children by day 3 and day 7, respectively. Plasma vitamin A, alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin, and vitamin E were depressed at enrollment and increased by day 7. Multivariate analyses showed that higher plasma lycopene concentrations at enrollment were associated with clearance of parasitemia between enrollment and day 3 (odds ratio = 1.46, 95% confidence interval = 1.07-2.06, per 0.10 micromol/L of lycopene). This study suggests that children with acute malaria have depressed plasma concentrations of antioxidants, and that higher plasma lycopene is associated with more rapid clearance of malaria parasitemia.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 67 | 67 | 5 |
| Full Text Views | 514 | 285 | 1 |
| PDF Downloads | 99 | 32 | 0 |