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An outbreak of fulminant hepatitis delta in the Waorani, an indigenous people of the Amazon basin of Ecuador.
S R Manock
S R Manock
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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P M Kelley
P M Kelley
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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K C Hyams
K C Hyams
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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R Douce
R Douce
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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R D Smalligan
R D Smalligan
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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D M Watts
D M Watts
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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T W Sharp
T W Sharp
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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J L Casey
J L Casey
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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J L Gerin
J L Gerin
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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R Engle
R Engle
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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A Alava-Alprecht
A Alava-Alprecht
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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C M MartÃnez
C M MartÃnez
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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N B Bravo
N B Bravo
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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A G Guevara
A G Guevara
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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K L Russell
K L Russell
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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W Mendoza
W Mendoza
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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C Vimos
C Vimos
Hospital Vozandes del Oriente, Shell, Pastaza, Ecuador.
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An outbreak of delta hepatitis occurred during 1998 among the Waorani of the Amazon basin of Ecuador. Among 58 people identified with jaundice, 79% lived in four of 22 Waorani communities. Serum hepatitis B surface antigen (HBsAg) was found in the sera of 54% of the jaundiced persons, and 14% of asymptomatic persons. Ninety-five percent of 105 asymptomatic Waorani had hepatitis B core (HBc) IgG antibody, versus 98% of 51 with jaundice. These data confirm that hepatitis B virus (HBV) infection is highly endemic among the Waorani. Sixteen of 23 (70%) HBsAg carriers identified at the onset of the epidemic had serologic markers for hepatitis D virus (HDV) infection. All 16 were jaundiced, where as only two of seven (29%) with negative HDV serology were jaundiced (P = .0006). The delta cases clustered in families, 69% were children and most involved superinfection of people chronically infected with HBV. The data suggest that HDV spread rapidly by a horizontal mode of transmission other than by the sexual route.
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| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1049 | 943 | 311 |
| Full Text Views | 444 | 15 | 6 |
| PDF Downloads | 274 | 10 | 1 |