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Serologic responses of Korean soldiers serving in malaria-endemic areas during a recent outbreak of Plasmodium vivax.
C G Park
C G Park
Korean Armed Forces Central Medical Research Institute, Chumok-dong, Yuseong-gu, Taejeon, Republic of Korea. parkc@mail.rockefeller.edu
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Y J Chwae
Y J Chwae
Korean Armed Forces Central Medical Research Institute, Chumok-dong, Yuseong-gu, Taejeon, Republic of Korea. parkc@mail.rockefeller.edu
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J I Kim
J I Kim
Korean Armed Forces Central Medical Research Institute, Chumok-dong, Yuseong-gu, Taejeon, Republic of Korea. parkc@mail.rockefeller.edu
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J H Lee
J H Lee
Korean Armed Forces Central Medical Research Institute, Chumok-dong, Yuseong-gu, Taejeon, Republic of Korea. parkc@mail.rockefeller.edu
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G M Hur
G M Hur
Korean Armed Forces Central Medical Research Institute, Chumok-dong, Yuseong-gu, Taejeon, Republic of Korea. parkc@mail.rockefeller.edu
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B H Jeon
B H Jeon
Korean Armed Forces Central Medical Research Institute, Chumok-dong, Yuseong-gu, Taejeon, Republic of Korea. parkc@mail.rockefeller.edu
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J S Koh
J S Koh
Korean Armed Forces Central Medical Research Institute, Chumok-dong, Yuseong-gu, Taejeon, Republic of Korea. parkc@mail.rockefeller.edu
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J H Han
J H Han
Korean Armed Forces Central Medical Research Institute, Chumok-dong, Yuseong-gu, Taejeon, Republic of Korea. parkc@mail.rockefeller.edu
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S J Lee
S J Lee
Korean Armed Forces Central Medical Research Institute, Chumok-dong, Yuseong-gu, Taejeon, Republic of Korea. parkc@mail.rockefeller.edu
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J W Park
J W Park
Korean Armed Forces Central Medical Research Institute, Chumok-dong, Yuseong-gu, Taejeon, Republic of Korea. parkc@mail.rockefeller.edu
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D C Kaslow
D C Kaslow
Korean Armed Forces Central Medical Research Institute, Chumok-dong, Yuseong-gu, Taejeon, Republic of Korea. parkc@mail.rockefeller.edu
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D Strickman
D Strickman
Korean Armed Forces Central Medical Research Institute, Chumok-dong, Yuseong-gu, Taejeon, Republic of Korea. parkc@mail.rockefeller.edu
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C S Roh
C S Roh
Korean Armed Forces Central Medical Research Institute, Chumok-dong, Yuseong-gu, Taejeon, Republic of Korea. parkc@mail.rockefeller.edu
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Anti-Pv200 antibody levels were assessed in samples from endemic areas of Plasmodium vivax malaria in the Republic of Korea (ROK), using an indirect enzyme-linked immunosorbent assay (ELISA) method. Asymptomatic carriers of P. vivax were detected using nested polymerase chain reaction (PCR) of blood samples. Anti-Pv200 antibody levels in 20 vivax malaria patients (optical density +/- standard deviation [OD +/- SD] values 1.85 +/- 0.29 of IgG isotype and 1.33 +/- 1.33 of IgM isotype) were markedly higher than those of uninfected, malaria-naive controls (0.08 +/- 0.16 of IgG isotype and 0.04 +/- 0.04 of IgM isotype). Antibody levels for 7 out of 8 soldiers with a recent malaria infection were sustained above the cut-off values for 4 months after successful treatment. Analysis of serum collected from 40 healthy, asymptomatic soldiers who had a P. vivax malaria attack within 3 months after our sampling, revealed 11 antibody-positive samples (27.5%), compared to 5 positive samples (12.5%) collected from a random selection of 40 soldiers. Among a larger pool of 1,713 soldiers who had served in high-risk areas for P. vivax transmission, 15% were antibody positive. Among 1,000 blood samples from asymptomatic soldiers who had served in the high-risk areas, 4 samples (0.4%) were parasite positive, as determined by nested PCR. Our results show that anti-Pv200 antibody levels can provide useful information in the late diagnosis of P. vivax malaria infection in a previously naive population and also in large seroepidemiologic studies. Furthermore, our results suggest that asymptomatic P. vivax carriers could be important in the current outbreak of malaria in Korea.
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| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 130 | 99 | 31 |
| Full Text Views | 292 | 8 | 0 |
| PDF Downloads | 59 | 8 | 0 |