A randomized controlled trial of artemotil (beta-arteether) in Zambian children with cerebral malaria.

P E Thuma Department of Natural Sciences, Messiah College, Grantham, Pennsylvania 17027, USA. pthuma@messiah.edu

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G J Bhat Department of Natural Sciences, Messiah College, Grantham, Pennsylvania 17027, USA. pthuma@messiah.edu

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G F Mabeza Department of Natural Sciences, Messiah College, Grantham, Pennsylvania 17027, USA. pthuma@messiah.edu

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C Osborne Department of Natural Sciences, Messiah College, Grantham, Pennsylvania 17027, USA. pthuma@messiah.edu

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G Biemba Department of Natural Sciences, Messiah College, Grantham, Pennsylvania 17027, USA. pthuma@messiah.edu

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G M Shakankale Department of Natural Sciences, Messiah College, Grantham, Pennsylvania 17027, USA. pthuma@messiah.edu

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P A Peeters Department of Natural Sciences, Messiah College, Grantham, Pennsylvania 17027, USA. pthuma@messiah.edu

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B Oosterhuis Department of Natural Sciences, Messiah College, Grantham, Pennsylvania 17027, USA. pthuma@messiah.edu

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C B Lugt Department of Natural Sciences, Messiah College, Grantham, Pennsylvania 17027, USA. pthuma@messiah.edu

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V R Gordeuk Department of Natural Sciences, Messiah College, Grantham, Pennsylvania 17027, USA. pthuma@messiah.edu

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DOI:
https://doi.org/10.4269/ajtmh.2000.62.524
Volume/Issue:
Volume 62: Issue 4
Page(s):
524–529
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The efficacy and safety of intramuscular artemotil (ARTECEF) was compared to intravenous quinine in African children with cerebral malaria. This prospective block randomized open-label study was conducted at two centers in Zambia. Subjects were children aged 0 to 10 years of age with cerebral malaria and a Blantyre Coma Score of 2 or less. Ninety two children were studied; 48 received artemotil and 44 quinine. No significant differences in survival, coma resolution time, neurologic sequelae, parasite clearance time, and fever resolution time were seen between the two regimens. Rates for negative malaria smears one month after therapy were similar in both groups. Artemotil was a well-tolerated drug in the 48 patients in this study. It appears to be at least therapeutically equivalent to quinine for the treatment of pediatric cerebral malaria. It has the advantage of being able to be given intramuscularly once daily for only five days.

Author Notes

Published Online:
Apr 2000
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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