Randomized trial of the immunogenicity of fractional dose regimens of PRP-T Haemophilus influenzae type b conjugate vaccine.

J Fernández Departamento de Enfermedades Infecciosas, Clínica Infantil, Robert Reid Cabral, Santo Domingo, Dominican Republic. infectologia@codetel.net.do

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S Balter Departamento de Enfermedades Infecciosas, Clínica Infantil, Robert Reid Cabral, Santo Domingo, Dominican Republic. infectologia@codetel.net.do

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J Feris Departamento de Enfermedades Infecciosas, Clínica Infantil, Robert Reid Cabral, Santo Domingo, Dominican Republic. infectologia@codetel.net.do

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E Gómez Departamento de Enfermedades Infecciosas, Clínica Infantil, Robert Reid Cabral, Santo Domingo, Dominican Republic. infectologia@codetel.net.do

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Z Garib Departamento de Enfermedades Infecciosas, Clínica Infantil, Robert Reid Cabral, Santo Domingo, Dominican Republic. infectologia@codetel.net.do

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P L Castellanos Departamento de Enfermedades Infecciosas, Clínica Infantil, Robert Reid Cabral, Santo Domingo, Dominican Republic. infectologia@codetel.net.do

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J Sánchez Departamento de Enfermedades Infecciosas, Clínica Infantil, Robert Reid Cabral, Santo Domingo, Dominican Republic. infectologia@codetel.net.do

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S Romero-Steiner Departamento de Enfermedades Infecciosas, Clínica Infantil, Robert Reid Cabral, Santo Domingo, Dominican Republic. infectologia@codetel.net.do

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O S Levine Departamento de Enfermedades Infecciosas, Clínica Infantil, Robert Reid Cabral, Santo Domingo, Dominican Republic. infectologia@codetel.net.do

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DOI:
https://doi.org/10.4269/ajtmh.2000.62.485
Volume/Issue:
Volume 62: Issue 4
Page(s):
485–490
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To assess the immunogenicity of more economical regimens of Haemophilus influenzae type b (Hib) conjugate vaccine, a randomized trial of fractional doses of polyribosylribitol phosphate-tetanus toxoid (PRP-T) Hib vaccine was undertaken in the Dominican Republic. Six hundred children were assigned to one of six regimens with PRP-T vaccine: full-dose, half-dose, and one-third-dose of Hib vaccine given separately or combined with diphtheria, tetanus, and pertussis (DTP) vaccine at ages 2, 4, and 6 months. Regimens that elicited antibody levels > 1.0 microg/mL in >70% of children and < or = 0.15 microg/mL in > 90% of children were considered acceptable. At 1 month post Dose 3, all regimens met the criteria for acceptable response. Among those who received Hib as a separate injection, geometric mean concentrations of anti-PRP bodies (GMCs) at age 1 month post Dose 3 were 11.2, 11.9, and 16.3 in the full, half, and one-third dose groups, respectively. Among those who received Hib and DTP combined, the GMCs were 6.4, 5.2, and 5.7 in the full-, half-, and one-third-dose groups respectively.

Author Notes

Published Online:
Apr 2000
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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