Past two years Past Year Past 30 Days
Abstract Views 2 2 2
Full Text Views 249 91 0
PDF Downloads 47 26 0
 
 
 
 
 
 
 
 
 
 
 

Hepatitis C virus genotypes in a northeastern area of Brazil.

L K SilvaLaboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.

Search for other papers by L K Silva in
Current site
Google Scholar
PubMed
Close
,
R ParanáLaboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.

Search for other papers by R Paraná in
Current site
Google Scholar
PubMed
Close
,
S P SouzaLaboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.

Search for other papers by S P Souza in
Current site
Google Scholar
PubMed
Close
,
F BerbyLaboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.

Search for other papers by F Berby in
Current site
Google Scholar
PubMed
Close
,
A KayLaboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.

Search for other papers by A Kay in
Current site
Google Scholar
PubMed
Close
,
C TrepóLaboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.

Search for other papers by C Trepó in
Current site
Google Scholar
PubMed
Close
,
N SantanaLaboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.

Search for other papers by N Santana in
Current site
Google Scholar
PubMed
Close
,
H CotrimLaboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.

Search for other papers by H Cotrim in
Current site
Google Scholar
PubMed
Close
,
L G LyraLaboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.

Search for other papers by L G Lyra in
Current site
Google Scholar
PubMed
Close
, and
M G ReisLaboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.

Search for other papers by M G Reis in
Current site
Google Scholar
PubMed
Close
View More View Less
Restricted access

We used a reverse transcription-polymerase chain reaction (RT-PCR) to obtain the genotypes of circulating hepatitis C virus (HCV) in patients from a Gastro-Hepatology Unit in the city of Salvador (Bahia State) in northeastern Brazil. Viral RNA was detected in 83 (65.4%) of 127 anti-HCV seropositive serum samples. Positivity was significantly associated with alterations in levels of aspartate aminotransferase and alanine aminotransferase (P < 0.05). Genotyping of HCV was performed by RT-PCR using genotype-specific primers from the core region: 24.1% were infected with subtype 1a, 38.6% with 1b, 3.6% with 2, 21.7% with 3a, and 12.0% with a mixed genotype. There was no difference in genotype distribution when compared with results from other Brazilian locations. Surprisingly, the high frequency of genotype 3 in Brazilian samples continues to be different from that reported around the world and warrants further investigation.

Save